公开(公告)号：US20200281977A1

公开(公告)日：2020-09-10

申请号：US16758136

申请日：2018-10-24

Applicant: HUMANITAS MIRASOLE S.P.A. ,  HUMANITAS UNIVERSITY

Inventor： Alberto MANTOVANI ,  Martina MOLGORA ,  Cecilia GARLANDA ,  Eduardo BONAVITA

IPC: A61K35/17 ,  C07K14/715 ,  C07K14/57 ,  A61P35/00 ,  C07K14/705

Abstract: The present invention refers to a stably or transiently IL-1R8 deficient isolated human cell, being a natural killer (NK) cell or T cell and to their medical use, preferably in the treatment of tumours and infections.

公开(公告)号：US20200164031A1

公开(公告)日：2020-05-28

申请号：US16069676

申请日：2016-09-27

Applicant: HUMANITAS MIRASOLE S.P.A

Inventor： Marinos Kallikourdis ,  Gianluigi Condorelli

IPC: A61K38/17 ,  C07K16/28 ,  A61P9/04

Abstract: The present invention relates to the use of inhibitors of T cell costimulation and/or activation and/or function in the treatment and/or prevention of cardiac pathologies, in particular heart failure diseases, and/or of related symptoms.

公开(公告)号：US20190079103A1

公开(公告)日：2019-03-14

申请号：US15773615

申请日：2016-11-07

Applicant: HUMANITAS MIRASOLE S.P.A.

Inventor： Gianluigi CONDORELLI ,  Achille ANSELMO ,  Chiara VIVIANI ANSELMI ,  Laura PAPA

IPC: G01N33/68 ,  G01N33/543

Abstract: The present invention refers to a method for characterizing and/or measuring and/or sorting the amount of cardiac-derived microvesicles, having the step of detecting CD172a marker on the microvesicles, in an isolated biological sample obtained from the subject.

公开(公告)号：US11913938B2

公开(公告)日：2024-02-27

申请号：US17435941

申请日：2020-03-03

Applicant: HUMANITAS MIRASOLE S.P.A. ,  POLITECNICO DI MILANO

Inventor： Gianluigi Taverna ,  Fabio Grizzi ,  Laura Maria Teresa Capelli ,  Carmen Bax ,  Selena Sironi ,  Lidia Giuseppina Eusebio

IPC: G01N33/493 ,  G01N27/12 ,  G01N33/574

CPC classification number: G01N33/493 ,  G01N27/12 ,  G01N33/57434

Abstract: Disclosed are methods for assessing the risk that a male subject is affected by prostate cancer and to methods for assessing the risk that such cancer is aggressive, by analysing the gaseous headspace of urine samples with at least three metal oxide semiconductor-based gas sensors, wherein the metal oxide of the first gas sensor is pure or doped SnO2, the metal oxide of the second sensor is pure or doped ZnO and the metal oxides of the third sensor are pure or doped SnO2, pure or doped TiO2 and pure or doped Nb2O5.

公开(公告)号：US20230251274A1

公开(公告)日：2023-08-10

申请号：US18003064

申请日：2021-06-25

Applicant: HUMANITAS MIRASOLE S.P.A. ,  HUMANITAS UNIVERSITY

Inventor： Barbara BOTTAZZI ,  Cecilia GARLANDA ,  Alberto MANTOVANI

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2333/4715

Abstract: The present invention refers to an in-vitro or ex vivo method for the prognosis of a Coronavirus disease and/or for the monitoring of the efficacy of a therapeutic treatment of a Coronavirus disease having the steps of: a) detecting and/or measuring the amount of the protein PTX3 or of fragments thereof or of the polynucleotide coding for the protein or of fragments thereof in an isolated biological sample obtained from the subject Preferably the method further includes—the step: b) comparing the same with a proper control.

公开(公告)号：US20220146493A1

公开(公告)日：2022-05-12

申请号：US17435941

申请日：2020-03-03

Applicant: HUMANITAS MIRASOLE S.P.A. ,  POLITECNICO DI MILANO

Inventor： Gianluigi TAVERNA ,  Fabio GRIZZI ,  Laura Maria Teresa CAPELLI ,  Carmen BAX ,  Selena SIRONI ,  Lidia Giuseppina EUSEBIO

IPC: G01N33/493 ,  G01N27/12

Abstract: Disclosed are methods for assessing the risk that a male subject is affected by prostate cancer and to methods for assessing the risk that such cancer is aggressive, by analysing the gaseous headspace of urine samples with at least three metal oxide semiconductor-based gas sensors, wherein the metal oxide of the first gas sensor is pure or doped SnO2, the metal oxide of the second sensor is pure or doped ZnO and the metal oxides of the third sensor are pure or doped SnO2, pure or doped TiO2 and pure or doped Nb2O5.

公开(公告)号：US11254739B2

公开(公告)日：2022-02-22

申请号：US16648333

申请日：2018-09-19

Applicant: HUMANITAS MIRASOLE S.P.A.

Inventor： Alberto Mantovani ,  Barbara Bottazzi ,  Ilaria Laface ,  Antonio Inforzato ,  Tamara Gulic

IPC: C07K16/24 ,  G01N33/68

Abstract: The present invention refers to an antibody able to recognize and bind to an epitope comprised in a sequence of human Migration Stimulating Factor (MSF), and that doesn't recognize and bind human Fibronectin 1 (hFn1) and to uses in diagnostic methods and therapy.

公开(公告)号：US20200283515A1

公开(公告)日：2020-09-10

申请号：US16648333

申请日：2018-09-19

Applicant: HUMANITAS MIRASOLE S.P.A. ,  UNIVERSITA' DEGLI STUDI DI MILANO

Inventor： Alberto MANTOVANI ,  Barbara BOTTAZZI ,  Ilaria LAFACE ,  Antonio INFORZATO ,  Tamara GULIC

IPC: C07K16/24 ,  G01N33/68

Abstract: The present invention refers to an antibody able to recognize and bind to an epitope comprised in a sequence of human Migration Stimulating Factor (MSF), and that doesn't recognize and bind human Fibronectin 1 (hFn1) and to uses in diagnostic methods and therapy.

公开(公告)号：US10350063B2

公开(公告)日：2019-07-16

申请号：US15319362

申请日：2015-06-17

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  HUMANITAS MIRASOLE S.P.A.

Inventor： Giorgio Soldani ,  Mattia Glauber

IPC: A61F2/24 ,  A61L27/18 ,  A61L27/50 ,  B29C41/00 ,  B29C41/08 ,  B29C43/00 ,  B29C43/02 ,  B29C43/36 ,  B29C43/52 ,  B29K69/00 ,  B29K75/00 ,  B29K83/00 ,  B29L31/00 ,  C08L83/04

Abstract: A process for the manufacture of a heart valve of polymer material which provides for the deposition of a polymer solution comprising a copolymer which is preferably a copolymer of poly(carbonato-urethane) fluoridate (F-PCU) and intracatenary polydimethylsiloxane (PDMS), a PDMS with a functional group outside the chain and a solvent onto a mould using a spray technique associated with phase inversion.

公开(公告)号：US20160312296A1

公开(公告)日：2016-10-27

申请号：US15104129

申请日：2014-12-16

Applicant: HUMANITAS MIRASOLE S.P.A.

Inventor： Luigi LAGHI ,  Giuseppe CELESTI

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158

Abstract: The present invention concerns a method for determining if a subject is affected by a colorectal or pancreatic cancer or for determining the stage and/or the progression of a colorectal cancer. By measuring the presence of a panel of m RNAs encoding for transcription factors/genes involved in epithelial to mesenchymal transition in a blood sample, wherein different mRNA levels of a set of genes comprising TWIST1, SLUG, ZEB2, ZEB1 and CDH1, are indicative of colorectal cancer or pancreatic cancer diagnosis, and/or of colorectal cancer stage at diagnosis, and/or of CRC metastatic progression after surgery. The invention concerns also the use of kits to work the method.

Abstract translation: 本发明涉及一种用于确定受试者是否受到结肠直肠癌或胰腺癌的影响或用于确定结肠直肠癌的阶段和/或进展的方法。 通过测量编码在血液样品中参与上皮至间质转化的转录因子/基因的一组m RNA的存在，其中包含TWIST1，SLUG，ZEB2，ZEB1和CDH1的一组基因的不同mRNA水平指示 结肠直肠癌或胰腺癌诊断，和/或诊断时的结肠直肠癌分期，和/或手术后CRC转移进展。 本发明还涉及使用试剂盒来处理该方法。