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    VAGINAL DELIVERY SYSTEM
    14.
    发明申请
    VAGINAL DELIVERY SYSTEM 审中-公开
    VAGINAL交付系统

    公开(公告)号：US20090142313A1

    公开(公告)日：2009-06-04

    申请号：US12275115

    申请日：2008-11-20

    申请人： Christine Talling ,  Vladimir Hanes ,  Antti Keinanen ,  Svante Holmberg ,  Hannu Nikander

    发明人： Christine Talling ,  Vladimir Hanes ,  Antti Keinanen ,  Svante Holmberg ,  Hannu Nikander

    IPC分类号： A61K31/585 ,  A61P31/04 ,  A61P31/10 ,  A61K35/74

    CPC分类号： A61K31/56 ,  A61K9/0036 ,  A61K31/565 ,  A61K31/585 ,  A61K2300/00

    摘要： The present invention is related to an intravaginal delivery system for the controlled release of drospirenone and an estrogen, optionally also comprising one or more therapeutically active or a health-promoting substance capable of giving and/or enhancing protection against bacterial and fungal infections, and/or enhancing protection against sexually transmitted diseases. The delivery system consists of one or more compartments, one of each comprising a core and a membrane encasing the core, said core and membrane essentially consisting of a same or different polymer composition, wherein at least one compartment comprises drospirenone ant at least one compartment which may be the same or different from the one comprising drospirenone, comprises an estrogen or a mixture of drospirenone and an estrogen, and wherein the membrane or the surface of the membrane or at least one of the cores comprises said therapeutically active or a health-promoting substance.

    摘要翻译： 本发明涉及用于控制释放屈螺酮和雌激素的阴道内递送系统，任选地还包含一种或多种治疗活性或健康促进物质，其能够产生和/或增强针对细菌和真菌感染的保护和/ 或加强对性传播疾病的保护。 递送系统由一个或多个隔室组成，每个隔室中的一个包括芯和包围芯的膜，所述芯和膜基本上由相同或不同的聚合物组合物组成，其中至少一个隔室包含屈螺酮蚂蚁至少一个隔室， 可以与包含屈螺酮的那些相同或不同，包括雌激素或屈螺酮和雌激素的混合物，并且其中膜或膜的表面或至少一个核包含所述治疗活性或健康促进作用 物质。