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    Otorhinological delivery device
    3.
    发明授权
    Otorhinological delivery device 有权
    耳道输送装置

    公开(公告)号：US07294345B2

    公开(公告)日：2007-11-13

    申请号：US10542420

    申请日：2004-01-14

    申请人： Timo Haapakumpu ,  Harri Jukarainen ,  Juha Ala-Sorvari ,  Henry Rankonen ,  Frederik E. Riphagen ,  Wolfgang Arnold

    发明人： Timo Haapakumpu ,  Harri Jukarainen ,  Juha Ala-Sorvari ,  Henry Rankonen ,  Frederik E. Riphagen ,  Wolfgang Arnold

    IPC分类号： A61F11/00

    CPC分类号： A61K9/0046 ,  A61K9/0043 ,  A61L31/06 ,  A61L31/16 ,  Y10S514/953 ,  C08L83/04

    摘要： The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof, and a membrane encasing said core, said membrane being made of a same or a different elastomer composition than said core, said elastomer composition being selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof. The invention is characterized in that the pharmaceutically active agent is selected from the group comprising anti-allergic agents, anti-inflammatory agents, anti-fungicides, glucocorticoids and mixtures thereof.

    摘要翻译： 本发明涉及包含至少一种药物活性剂的运输装置。 根据本发明，该装置包括一种包含所述至少一种药物活性剂的核心，其中所述核心由弹性体组合物制成，所述弹性体组合物选自聚（二甲基硅氧烷），包含3,3,3-三氟丙基 连接到硅氧烷单元的硅原子的基团，包含聚（环氧烷）基团的硅氧烷基弹性体及其混合物，以及包围所述芯的膜，所述膜由与所述芯相同或不同的弹性体组合物制成，所述 弹性体组合物选自聚（二甲基硅氧烷），包含连接到硅氧烷单元的硅原子上的3,3,3-三氟丙基的硅氧烷基弹性体，包含聚（氧化烯）基团的硅氧烷基弹性体和 其混合物。 本发明的特征在于药物活性剂选自抗过敏剂，抗炎剂，抗真菌剂，糖皮质激素及其混合物。

    USE OF TOCOPHEROL
    5.
    发明申请
    USE OF TOCOPHEROL 有权
    使用植物油

    公开(公告)号：US20100036079A1

    公开(公告)日：2010-02-11

    申请号：US12529338

    申请日：2008-03-11

    申请人： Emilia Tiitinen ,  Harri Jukarainen

    发明人： Emilia Tiitinen ,  Harri Jukarainen

    IPC分类号： C08G77/08 ,  C08G77/04 ,  C07D311/72

    CPC分类号： C08G77/38 ,  C08G77/08 ,  C08G77/14

    摘要： The present invention relates to the use of tocopherol as a co-catalyst in the ring opening polymerisation of cyclic siloxanes. The present invention further relates to a method for manufacturing hydrophilic polysiloxanes, wherein a hydrido-containing cyclic siloxane is reacted with a hydrophilic molecule comprising a carbon-carbon double bond, having the general formula (I) H2C═CH—(CHR)n—O—(CHR1CR2R3)mR4 or (II) H2C═CH—(CHR)n—R5, wherein n is an integer from 0 to 4, m is an integer from 0 to 5, R, R1, R2, R3 and R4 are each independently hydrogen or a C1 to C6 alkyl, R5 is a saturated cyclic hydrocarbon containing carbonyl group, in the presence of a first catalyst to obtain a monomer, and polymerising said monomer in the presence of a second catalyst and tocopherol as a co-catalyst.

    摘要翻译： 本发明涉及在环状硅氧烷的开环聚合中使用生育酚作为助催化剂。 本发明还涉及亲水性聚硅氧烷的制造方法，其中含氢环状硅氧烷与包含碳 - 碳双键的亲水性分子反应，具有通式（I）H 2 C-CH-（CHR）n O- （CHR 1 CR 2 R 3）m R 4或（II）H 2 C-CH-（CHR）n -R 5，其中n为0至4的整数，m为0至5的整数，R，R 1，R 2，R 3和R 4各自独立地为 氢或C1至C6烷基，R5是含有羰基的饱和环状烃，在第一催化剂存在下获得单体，并在第二催化剂和作为助催化剂的生育酚存在下使所述单体聚合。

    Otorhinological delivery device
    6.
    发明申请
    Otorhinological delivery device 有权
    耳道输送装置

    公开(公告)号：US20060067982A1

    公开(公告)日：2006-03-30

    申请号：US10542420

    申请日：2004-01-14

    申请人： Timo Haapakumpu ,  Harri Jukarainen ,  Juha Ala-Sorvari ,  Frederik Riphagen ,  Wolfgang Arnold

    发明人： Timo Haapakumpu ,  Harri Jukarainen ,  Juha Ala-Sorvari ,  Frederik Riphagen ,  Wolfgang Arnold

    IPC分类号： A61F11/00

    CPC分类号： A61K9/0046 ,  A61K9/0043 ,  A61L31/06 ,  A61L31/16 ,  Y10S514/953 ,  C08L83/04

    摘要： The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof, and a membrane encasing said core, said membrane being made of a same or a different elastomer composition than said core, said elastomer composition being selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof. The invention is characterized in that the pharmaceutically active agent is selected from the group comprising anti-allergic agents, anti-inflammatory agents, anti-fungicides, glucocorticoids and mixtures thereof.

    摘要翻译： 本发明涉及包含至少一种药物活性剂的运输装置。 根据本发明，该装置包括一种包含所述至少一种药物活性剂的核心，其中所述核心由弹性体组合物制成，所述弹性体组合物选自聚（二甲基硅氧烷），包含3,3,3-三氟丙基 连接到硅氧烷单元的硅原子的基团，包含聚（环氧烷）基团的硅氧烷基弹性体及其混合物，以及包围所述芯的膜，所述膜由与所述芯相同或不同的弹性体组合物制成，所述 弹性体组合物选自聚（二甲基硅氧烷），包含连接到硅氧烷单元的硅原子上的3,3,3-三氟丙基的硅氧烷基弹性体，包含聚（氧化烯）基团的硅氧烷基弹性体和 其混合物。 本发明的特征在于药物活性剂选自抗过敏剂，抗炎剂，抗真菌剂，糖皮质激素及其混合物。

    Membrane or matrix for controlling the permeation rate of drugs
    7.
    发明授权
    Membrane or matrix for controlling the permeation rate of drugs 有权
    用于控制药物渗透速率的膜或基质

    公开(公告)号：US06794464B2

    公开(公告)日：2004-09-21

    申请号：US10298195

    申请日：2002-11-18

    申请人： Harri Jukarainen ,  Tommi Markkula ,  Juha Ala-Sorvari ,  Matti Lehtinen ,  Jarkko Ruohonen

    发明人： Harri Jukarainen ,  Tommi Markkula ,  Juha Ala-Sorvari ,  Matti Lehtinen ,  Jarkko Ruohonen

    IPC分类号： C08L8310

    CPC分类号： C08L83/12 ,  A61K9/0024 ,  A61K9/0036 ,  A61K9/0039 ,  A61K9/2027 ,  A61K9/2031

    摘要： A membrane or matrix for controlling the permeation rate of a drug, where the membrane or matrix includes a siloxane-based elastomer composition which contains at least one elastomer and optionally a non-crosslinked polymer. The elastomer composition includes poly(alkylene oxide) groups, and the poly(alkylene oxide) groups are present as blocks in a chain of the elastomer or the polymer, or as blocks and alkoxy-terminated grafts of polysiloxane units, the blocks or blocks and grafts being linked to the polysiloxane units by silicon-carbon bonds, with at least three blocks being present in the elastomer or polymer chain. Methods for the preparation of the elastomer composition are also disclosed.

    摘要翻译： 用于控制药物渗透速率的膜或基质，其中膜或基质包括含有至少一种弹性体和任选的非交联聚合物的硅氧烷基弹性体组合物。 弹性体组合物包括聚（环氧烷）基团，聚（环氧烷）基团作为嵌段存在于弹性体或聚合物的链中，或作为聚硅氧烷单元的嵌段和烷氧基封端的接枝物，嵌段或嵌段 接枝物通过硅 - 碳键与聚硅氧烷单元连接，至少有三个嵌段存在于弹性体或聚合物链中。 还公开了制备弹性体组合物的方法。

    Elastomer, its preparation and use
    9.
    发明授权
    Elastomer, its preparation and use 有权
    弹性体，其制备和使用

    公开(公告)号：US06056976A

    公开(公告)日：2000-05-02

    申请号：US190608

    申请日：1998-11-12

    申请人： Tommi Markkula ,  Juha Ala-Sorvari ,  Harri Jukarainen ,  Matti Lehtinen ,  Jarkko Rughonen

    发明人： Tommi Markkula ,  Juha Ala-Sorvari ,  Harri Jukarainen ,  Matti Lehtinen ,  Jarkko Rughonen

    IPC分类号： A61L27/00 ,  A61K9/00 ,  A61K9/20 ,  A61K9/52 ,  A61K9/58 ,  C08G77/24 ,  C08J5/18 ,  C08K3/36 ,  C08K5/54 ,  C08L83/04 ,  C08L83/08 ,  A61K9/14

    CPC分类号： A61K9/0039 ,  A61K9/009 ,  A61K9/2036

    摘要： The invention relates to a siloxane-based elastomer intended for controlling the permeation of drugs, wherein the elastomer includes 3,3,3,-trifluoropropyl groups attached to the Si-atoms of the siloxane units.The invention relates also to a method for the preparation of a siloxane-based elastomer including 3,3,3,-trifluoropropyl substituents, where the elastomer is intended for controlling the permeation of drugs.In the method eitheri) a 3,3,3,-trifluoropropyl-substituted vinyl-functional polysiloxane component and a silicon hydride-functional crosslinking agent are crosslinked in the presence of a catalyst, orii) a 3,3,3,-trifluoropropyl-substituted polysiloxane component is crosslinked in the presence of a peroxide catalyst.

    摘要翻译： 本发明涉及一种旨在控制药物渗透性的硅氧烷基弹性体，其中弹性体包括连接到硅氧烷单元的Si原子上的3,3,3-三氟丙基。 本发明还涉及制备包含3,3,3-三氟丙基取代基的硅氧烷基弹性体的方法，其中弹性体用于控制药物的渗透。 在该方法中，i）3,3,3,3-三氟丙基取代的乙烯基官能聚硅氧烷组分和硅氢化物官能的交联剂在催化剂存在下进行交联，或ii）3,3,3， 三氟丙基取代的聚硅氧烷组分在过氧化物催化剂存在下交联。

    Use of tocopherol
    10.
    发明授权
    Use of tocopherol 有权
    使用生育酚

    公开(公告)号：US08044161B2

    公开(公告)日：2011-10-25

    申请号：US12529338

    申请日：2008-03-11

    申请人： Emilia Tiitinen ,  Harri Jukarainen

    发明人： Emilia Tiitinen ,  Harri Jukarainen

    IPC分类号： C08G77/08 ,  C08G77/04 ,  C07D311/72

    CPC分类号： C08G77/38 ,  C08G77/08 ,  C08G77/14

    摘要： The present invention relates to the use of tocopherol as a co-catalyst in the ring opening polymerisation of cyclic siloxanes. The present invention further relates to a method for manufacturing hydrophilic polysiloxanes, wherein a hydrido-containing cyclic siloxane is reacted with a hydrophilic molecule comprising a carbon-carbon double bond, having the general formula (I) H2C═CH—(CHR)n—O—(CHR1CR2R3)mR4 or (II) H2C═CH—(CHR)n—R5, wherein n is an integer from 0 to 4, m is an integer from 0 to 5, R, R1, R2, R3 and R4 are each independently hydrogen or a C1 to C6 alkyl, R5 is a saturated cyclic hydrocarbon containing carbonyl group, in the presence of a first catalyst to obtain a monomer, and polymerising said monomer in the presence of a second catalyst and tocopherol as a co-catalyst.

    摘要翻译： 本发明涉及在环状硅氧烷的开环聚合中使用生育酚作为助催化剂。 本发明还涉及亲水性聚硅氧烷的制造方法，其中含氢环状硅氧烷与包含碳 - 碳双键的亲水性分子反应，所述亲水性分子具有通式（I）H 2C≡CH-（CHR）n- O-（CHR 1 CR 2 R 3）m R 4或（II）H 2C≡CH-（CHR）n -R 5，其中n为0至4的整数，m为0至5的整数，R，R 1，R 2，R 3和R 4为 各自独立地为氢或C1〜C6烷基，R5为含有羰基的饱和环状烃，在第一催化剂存在下得到单体，并在第二催化剂和生育酚作为助催化剂存在下使所述单体聚合 。