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公开(公告)号：US4113723A
公开(公告)日：1978-09-12
申请号：US854392
申请日：1977-11-23
IPC分类号： C07F9/655 , C07F9/6553 , C07D307/54
CPC分类号： C07F9/655345 , C07F9/65515 , B63B2211/02
摘要： The 15-substituted-.omega.-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.
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公开(公告)号：US3980642A
公开(公告)日：1976-09-14
申请号：US633374
申请日：1975-11-19
IPC分类号： C07C405/00 , C07F9/6553 , C07C177/00
CPC分类号： C07F9/655345 , C07C405/00 , B63B2211/02
摘要： The 15-substituted-.omega.-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.
摘要翻译： 15-取代的ω-前药前列腺素及其制备中使用的各种中间体。 已经发现本发明的新型前列腺素具有与母体前列腺素相当的活性谱，但表现出较大的组织特异性作用。
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公开(公告)号：US3974213A
公开(公告)日：1976-08-10
申请号：US485491
申请日：1974-07-03
IPC分类号： C07C405/00 , C07D307/54 , C07D307/935 , C07D309/12 , C07D317/60 , C07D333/24 , C07F9/40 , C07F9/6553 , C07C61/06 , C07C61/20
CPC分类号： C07D307/935 , C07C405/00 , C07D307/54 , C07D309/12 , C07D317/60 , C07D333/24 , C07F9/40 , C07F9/4059 , C07F9/655345 , B63B2211/02 , Y10S514/821 , Y10S514/826 , Y10S514/929 , Y10S514/935
摘要： The 15 aryl substituted-.omega.-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.
摘要翻译： 15种芳基取代ω-pentanor前列腺素及其制备中使用的各种中间体。 已经发现本发明的新型前列腺素具有与母体前列腺素相当的活性谱，但表现出较大的组织特异性作用。
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公开(公告)号：US3974161A
公开(公告)日：1976-08-10
申请号：US485945
申请日：1974-07-05
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , Y10S514/826
摘要： Fused heterocyclic ring systems in which a quinoline or a pyridine component is "fused" to a pyrimidine having a 2-methyl, 2-ethyl, or 2-acetyl group and a 4-keto group, and to similar ring systems in which a quinoline, a naphthalene or a pyridine component is "fused" to a pyrimidine having a 2-carboxy group and a 4-keto group, derivatives, and pharmaceutically-acceptable cationic salts thereof, and their use as antiallergy agents, and intermediates therefor.
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15.发明授权2-Descarboxy-2-(tetrazol-5-yl)-16,16-dimethyl-17-( 2-furyl)-.omega.-trisnorprostaglandin E.sub.2 失效2-二羧基-2-（四唑-5-基）-16,16-二甲基-17-（2-呋喃基） - ω-前列醇前列腺素E2
公开(公告)号：US4342868A
公开(公告)日：1982-08-03
申请号：US249930
申请日：1981-04-01
IPC分类号： C07C405/00 , C07D307/935
CPC分类号： C07D307/935 , C07C405/0041 , Y10S514/843 , Y10S514/927 , Y10S514/935
摘要： 15-Substituted-.omega.-pentanorprostaglandin C-1 tetrazoles, imides and sulfonimides.Their use as anti-secretory agents or as agents for the control of fertility.
摘要翻译： 15-取代的ω-前药前列腺素C-1四唑，酰亚胺和磺酰亚胺。 它们用作抗分泌剂或作为控制生育力的药剂。
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公开(公告)号：US4143051A
公开(公告)日：1979-03-06
申请号：US854269
申请日：1977-11-23
IPC分类号： C07F9/655 , C07F9/6553 , C07C177/00
CPC分类号： C07F9/655345 , C07F9/65515 , B63B2211/02
摘要： The 15-substituted-.omega.-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.
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公开(公告)号：US4080368A
公开(公告)日：1978-03-21
申请号：US789519
申请日：1977-04-21
IPC分类号： C07F9/655 , C07F9/6553 , C07F9/40
CPC分类号： C07F9/655345 , C07F9/65515
摘要： The 15-substituted-.omega.-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.
摘要翻译： 15-取代的ω-前药前列腺素及其制备中使用的各种中间体。 已经发现本发明的新型前列腺素具有与母体前列腺素相当的活性谱，但表现出较大的组织特异性作用。
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公开(公告)号：US4044134A
公开(公告)日：1977-08-23
申请号：US667515
申请日：1976-03-16
IPC分类号： C07D215/54 , C07D265/26 , C07D471/04 , A61K31/505
CPC分类号： C07D471/04 , C07D215/54 , C07D265/26
摘要： Fused heterocyclic ring systems in which a quinoline or a pyridine component is "fused" to a pyrimidine having a 2-methyl, 2-ethyl, or 2-acetyl group and a 4-keto group, and to similar ring systems in which a quinoline, a naphthalene or a pyridine component is fused to a pyrimidine having a 2-carboxy group and a 4-keto group, derivatives, and pharmaceutically-acceptable cationic salts thereof, and their use as antiallergy agents, and intermediates therefor.
摘要翻译： 其中喹啉或吡啶组分与具有2-甲基，2-乙基或2-乙酰基和4-酮基的嘧啶“稠合”的稠合杂环体系，以及类似的环体系，其中喹啉 ，萘或吡啶成分与具有2-羧基和4-酮基的嘧啶，其衍生物和药学上可接受的阳离子盐，以及它们作为抗过敏剂及其中间体的用途融合。
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公开(公告)号：US4036832A
公开(公告)日：1977-07-19
申请号：US705767
申请日：1976-07-15
IPC分类号： C07C405/00 , C07D407/02 , C07D309/02
CPC分类号： C07C405/00
摘要： The 15-substituted-.omega.-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.
摘要翻译： 15-取代的ω-前药前列腺素及其制备中使用的各种中间体。 已经发现本发明的新型前列腺素具有与母体前列腺素相当的活性谱，但表现出较大的组织特异性作用。
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公开(公告)号：US3966936A
公开(公告)日：1976-06-29
申请号：US581830
申请日：1975-05-29
IPC分类号： A61K31/495 , A61K31/505
CPC分类号： A61K31/505 , A61K31/495
摘要： A series of novel 4-piperazino-6,7-dialkoxyquinazolines and 1-piperazino-6,7-dialkoxyisoquinolines have been prepared, including their acid addition salts. These compounds are useful in therapy as bronchodilators and as smooth muscle relaxants. Methods for their preparation from known compounds are provided.
摘要翻译： 已经制备了一系列新的4-哌嗪基-6,7-二烷氧基喹唑啉和1-哌嗪基-6,7-二烷氧基异喹啉，包括它们的酸加成盐。 这些化合物可用于治疗支气管扩张剂和平滑肌松弛剂。 提供了从已知化合物制备的方法。
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