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    Chloro- and alkoxy-substituted-2,4-diaminoquinazolines
    1.
    发明授权
    Chloro- and alkoxy-substituted-2,4-diaminoquinazolines 失效
    氯代和烷氧基取代的2,4-二氨基喹唑啉

    公开(公告)号：US4377581A

    公开(公告)日：1983-03-22

    申请号：US253052

    申请日：1981-04-10

    申请人： Hans-Jurgen E. Hess ,  Jasjit S. Bindra ,  Praful K. Shah

    发明人： Hans-Jurgen E. Hess ,  Jasjit S. Bindra ,  Praful K. Shah

    IPC分类号： C07C205/44 ,  C07C205/59 ,  C07D211/18 ,  C07D211/32 ,  C07D211/42 ,  C07D211/46 ,  C07D239/95 ,  C07D239/96 ,  C07D267/10 ,  C07D307/68 ,  C07D319/20 ,  C07D413/04 ,  A61K31/505 ,  C07D403/04

    CPC分类号： C07D413/04 ,  C07C205/44 ,  C07C205/59 ,  C07D211/18 ,  C07D211/32 ,  C07D211/42 ,  C07D211/46 ,  C07D239/95 ,  C07D239/96 ,  C07D267/10 ,  C07D307/68 ,  C07D319/20

    摘要： 2,4-Diaminoquinazolines of the formula ##STR1## wherein Y.sup.1 is hydrogen or chloro, Y.sup.2 is OR, Y.sup.3 is hydrogen or OR such than when Y.sup.1 is hydrogen, Y.sup.3 is OR and when Y.sup.1 is chloro, Y.sup.3 is hydrogen or OR, and the pharmaceutically acceptable salts thereof; R represents an alkyl group having from one to three carbon atoms;taken separately, R.sup.1 and R.sup.2 are each hydrogen, alkyl having from one to five carbon atoms, cycloalkyl having from three to eight carbon atoms, alkenyl or alkynyl each having from three to five carbon atoms or hydroxy substituted alkyl having from two to five carbon atoms, when taken together with the nitrogen atom to which they are attached R.sup.1 and R.sup.2 form a substituted or unsubstituted heterocyclic group optionally containing an atom of oxygen, sulfur or a second atom of nitrogen as a ring member; their use as antihypertensive agents, pharmaceutical compositions containing them and intermediates for their production.

    摘要翻译： 式（I）的2,4-二氨基喹唑啉其中Y1是氢或氯，Y2是OR，Y3是氢或OR，例如当Y1是氢时，Y3是OR，当Y1是氯时，Y3是氢或 或其药学上可接受的盐; R表示具有1至3个碳原子的烷基; 单独取代，R 1和R 2各自为氢，具有1至5个碳原子的烷基，具有3至8个碳原子的环烷基，各自具有3至5个碳原子的烯基或炔基或具有2至5个碳原子的羟基取代的烷基 当与其连接的氮原子一起时，R 1和R 2形成任选地含有氧原子，硫或第二氮原子作为环成员的取代或未取代的杂环基; 它们用作抗高血压剂，含有它们的药物组合物和用于其生产的中间体。

    Chloro- and alkoxy-substituted-2-chloro-4-aminodquinazolines
    2.
    发明授权
    Chloro- and alkoxy-substituted-2-chloro-4-aminodquinazolines 失效
    氯代和烷氧基取代的2-氯-4-氨基喹唑啉

    公开(公告)号：US4351940A

    公开(公告)日：1982-09-28

    申请号：US253236

    申请日：1981-04-13

    申请人： Hans-Jurgen E. Hess ,  Jasjit S. Bindra ,  Praful K. Shah

    发明人： Hans-Jurgen E. Hess ,  Jasjit S. Bindra ,  Praful K. Shah

    IPC分类号： C07C205/44 ,  C07C205/59 ,  C07D211/18 ,  C07D211/32 ,  C07D211/42 ,  C07D211/46 ,  C07D239/95 ,  C07D239/96 ,  C07D267/10 ,  C07D307/68 ,  C07D319/20 ,  C07D413/04

    CPC分类号： C07D413/04 ,  C07C205/44 ,  C07C205/59 ,  C07D211/18 ,  C07D211/32 ,  C07D211/42 ,  C07D211/46 ,  C07D239/95 ,  C07D239/96 ,  C07D267/10 ,  C07D307/68 ,  C07D319/20

    摘要： 2,4-Diaminoquinazolines of the formula ##STR1## wherein Y.sup.1 is hydrogen or chloro, Y.sup.2 is OR, Y.sup.3 is hydrogen or OR such that when Y.sup.1 is hydrogen, Y.sup.3 is OR and when Y.sup.1 is chloro, Y.sup.3 is hydrogen or OR, and the pharmaceutically acceptable salts thereof; R represents an alkyl group having from one to three carbon atoms;taken separately, R.sup.1 and R.sup.2 are each hydrogen, alkyl having from one to five carbon atoms, cycloalkyl having from three to eight carbon atoms, alkenyl or alkynyl each having from three to five carbon atoms or hydroxy substituted alkyl having from two to five carbon atoms, when taken together with the nitrogen atom to which they are attached R.sup.1 and R.sup.2 form a substituted or unsubstituted heterocyclic group optionally containing an atom of oxygen, sulfur or a second atom of nitrogen as a ring member; their use as antihypertensive agents, pharmaceutical compositions containing them and intermediates for their production.

    摘要翻译： 式（I）的2,4-二氨基喹唑啉其中Y1是氢或氯，Y2是OR，Y3是氢或OR，使得当Y1是氢时，Y3是OR，当Y1是氯时，Y3是氢或 或其药学上可接受的盐; R表示具有1至3个碳原子的烷基; 单独取代，R 1和R 2各自为氢，具有1至5个碳原子的烷基，具有3至8个碳原子的环烷基，各自具有3至5个碳原子的烯基或炔基或具有2至5个碳原子的羟基取代的烷基 当与其连接的氮原子一起时，R 1和R 2形成任选地含有氧原子，硫或第二氮原子作为环成员的取代或未取代的杂环基; 它们用作抗高血压剂，含有它们的药物组合物和用于其生产的中间体。

    13,14-Dihydro-15-alkenyl- and 13,14-dihydro-15-alkynyl prostaglandins and analogs thereof
    3.
    发明授权
    13,14-Dihydro-15-alkenyl- and 13,14-dihydro-15-alkynyl prostaglandins and analogs thereof 失效
    13,14-二氢-15-烯基 - 和13,14-二氢-15-炔基前列腺素及其类似物

    公开(公告)号：US4268522A

    公开(公告)日：1981-05-19

    申请号：US85907

    申请日：1979-10-18

    申请人： James F. Eggler ,  Hans-Jurgen E. Hess

    发明人： James F. Eggler ,  Hans-Jurgen E. Hess

    IPC分类号： C07C5/09 ,  C07C17/10 ,  C07C405/00

    CPC分类号： C07C405/00 ,  C07C17/10 ,  C07C5/09

    摘要： The invention discloses certain novel 13,14-dihydro-15-alkenyl prostaglandins and 13,14-dihydro-15-alkynyl prostaglandins and analogs of each as well as the novel intermediates employed in their preparation. The 9-oxo compounds of this novel series demonstrate selective bronchodilator activity, certain of these are also useful as antisecretory agents.

    摘要翻译： 本发明公开了一些新的13,14-二氢-15-烯基前列腺素和13,14-二氢-15-炔基前列腺素及其类似物以及其制备中所用的新型中间体。 该新型系列的9-氧代化合物表现出选择性支气管扩张剂活性，其中某些也可用作抗分泌剂。