公开(公告)号：US20080207552A1

公开(公告)日：2008-08-28

申请号：US11982970

申请日：2007-11-05

申请人： Yoshiki Sawa ,  Ryuichi Morishita ,  Yasufumi Kaneda ,  Hikaru Matsuda ,  Toshiki Yoshimine

发明人： Yoshiki Sawa ,  Ryuichi Morishita ,  Yasufumi Kaneda ,  Hikaru Matsuda ,  Toshiki Yoshimine

IPC分类号： A61K31/7088 ,  A61P9/10

CPC分类号： A61K9/0019 ,  A61K9/127 ,  A61K31/711 ,  A61K48/005 ,  A61K48/0075 ,  C07K14/4705 ,  C12N15/1131 ,  C12N15/115 ,  C12N15/86 ,  C12N2310/13 ,  C12N2310/315 ,  C12N2760/18811

摘要： The present invention provides introduction of NF-κB decoy oligodeoxynucleotide into rat cranial nerve through a carotid artery during global brain ischemia. Polymerase chain reaction demonstrated that one hour after global brain ischemia, transfected NF-κB decoy oligodeoxynucleotide effectively suppressed expression of tumor necrosis factor α, interleukin 1β and intracellular adhesion molecule 1 messenger RNAs. Terminal deoxynucleotidyl transferase-mediated deoxyuridine nick-end labeling staining and immunohistochemistry using microtubule-associated protein 2 demonstrated that transfected NF-κB decoy oligodeoxynucleotide significantly attenuated neuronal damage seven days after global brain ischemia. Therapeutic transfection of NF-κB decoy oligodeoxynucleotide during brain ischemia may be effective for attenuation of neuronal damage, suggesting a strategy for protecting the cerebrum from global ischemia.

摘要翻译： 本发明提供了在全脑缺血期间通过颈动脉将NF-κB诱饵寡脱氧核苷酸引入大鼠颅神经中。 聚合酶链反应表明，全球脑缺血后1小时，转染的NF-κB诱饵寡脱氧核苷酸有效抑制肿瘤坏死因子α，白细胞介素1β和细胞内粘附分子1信使RNA的表达。 末端脱氧核苷酸转移酶介导的脱氧尿苷切口末端标记染色和使用微管相关蛋白2的免疫组织化学证实，转染的NF-κB诱饵寡脱氧核苷酸在全脑缺血后7天显着减弱神经元损伤。 在脑缺血期间，NF-κB诱饵寡脱氧核苷酸的治疗转染对于减少神经元损伤可能是有效的，这表明保护大脑免受全身缺血的策略。

公开(公告)号：US4894721A

公开(公告)日：1990-01-16

申请号：US169411

申请日：1988-03-17

申请人： Hikaru Matsuda

发明人： Hikaru Matsuda

IPC分类号： H04N5/217 ,  H04N5/335 ,  H04N5/367 ,  H04N5/378

CPC分类号： H04N5/3675

摘要： A solid state imaging device is disclosed which includes a solid state sensor for converting an external scene into electrical signals, an A/D converter for converting output signals from the solid state sensor into digital signals, a frame memory for storing offset signals of the solid state sensor, and an arithmetic unit for subtracting the offset signals stored in the frame memory from the digital signals of the A/D converter, the signals from the arithmetic unit being output through a D/A converter and a synchronization adding circuit. In the thus constituted solid state imaging device, a judgement as to the level of the offset signal from the frame memory is made. If this level is lower than a predetermined value, it is judged that there is a defective pixel. Interpolation is then effected with neighboring peripheral pixel signals in a spatial processor.

摘要翻译： 公开了一种固态成像装置，其包括用于将外部场景转换为电信号的固态传感器，用于将来自固态传感器的输出信号转换为数字信号的A / D转换器，用于存储固体的偏移信号的帧存储器 状态传感器和用于从A / D转换器的数字信号中减去存储在帧存储器中的偏移信号的算术单元，来自运算单元的信号通过D / A转换器和同步加法电路输出。 在这样构成的固态成像装置中，作出关于来自帧存储器的偏移信号的电平的判断。 如果该电平低于预定值，则判断有缺陷像素。 然后在空间处理器中利用相邻周边像素信号进行插值。

公开(公告)号：US20050233299A1

公开(公告)日：2005-10-20

申请号：US10967247

申请日：2004-10-19

申请人： Yoshiki Sawa ,  Hikaru Matsuda ,  Toshikazu Nakamura ,  Shinya Mizuno

发明人： Yoshiki Sawa ,  Hikaru Matsuda ,  Toshikazu Nakamura ,  Shinya Mizuno

IPC分类号： A01N1/02

CPC分类号： A01N1/02 ,  A01N1/0226

摘要： A method of preserving a harvested organ, a harvested organ tissue or a part thereof for a long time, which comprises perfusing and/or immersing the harvested organ with a solution containing HGF having a temperature of 0 to 6° C., and which method is capable of maintaining harvested organs for transplantation in a high physiological state and preventing ischemia/reperfusion injury of the organs transplanted.

摘要翻译： 一种长期保存收获的器官，收获的器官组织或其部分的方法，其包括用含有0至6℃温度的HGF的溶液灌注和/或浸没收获的器官，以及哪种方法 能够在高生理状态下维持收集的器官移植，并预防移植器官的缺血/再灌注损伤。

公开(公告)号：US20050187221A1

公开(公告)日：2005-08-25

申请号：US10935466

申请日：2004-09-07

申请人： Hikaru Matsuda ,  Yoshiki Sawa ,  Masahiro Ryugo

发明人： Hikaru Matsuda ,  Yoshiki Sawa ,  Masahiro Ryugo

IPC分类号： A61K31/495

CPC分类号： A61K31/495

摘要： The invention provides a method of treating or preventing ischemia reperfusion injury in a subject in need thereof comprising administering a cytokine production inhibitor to a subject.

摘要翻译： 本发明提供了治疗或预防有需要的受试者的缺血再灌注损伤的方法，包括向受试者施用细胞因子产生抑制剂。