公开(公告)号：US09328059B2

公开(公告)日：2016-05-03

申请号：US13990301

申请日：2011-09-06

申请人： Ho Jeong Kwon ,  Yoon Sun Cho

发明人： Ho Jeong Kwon ,  Yoon Sun Cho

IPC分类号： A61K8/41 ,  A61Q19/02 ,  C07C211/42 ,  A61K31/135

CPC分类号： C07C211/42 ,  A61K8/41 ,  A61K31/135 ,  A61Q19/02

摘要： The present invention relates to a pharmaceutical composition for preventing or treating autophagy-related diseases, angiogenic diseases or hypermelanosis, comprising: (a) a pharmaceutically effective amount of an indatraline derivative or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier. The composition of the present invention effectively induces autophagy of cells, and thus is very effective for preventing or treating autophagy-related diseases. In addition, the composition of the present invention inhibits angiogenesis through the mechanism of inhibiting angiogenesis, invasion and metastasis and inhibits melanogenesis, and thus can also be effective for preventing or treating angiogenic diseases or melanin-related diseases.

摘要翻译： 本发明涉及一种用于预防或治疗自噬相关疾病，血管生成疾病或高致命性黑素沉着症的药物组合物，其包含：（a）药物有效量的靛蓝烷衍生物或其药学上可接受的盐; 和药学上可接受的载体。 本发明的组合物有效地诱导细胞自噬，因此对于预防或治疗自噬相关疾病非常有效。 此外，本发明的组合物通过抑制血管发生，侵袭和转移的机制抑制血管生成并抑制黑素生成，因此也可有效预防或治疗血管生成疾病或黑色素相关疾病。

公开(公告)号：US20110281826A1

公开(公告)日：2011-11-17

申请号：US13149166

申请日：2011-05-31

申请人： Uh-Hyun Kim ,  Ho-Jeong Kwon ,  Mie-Jae Im ,  Seon-Young Kim ,  Kwang-Hyun Park ,  So-Young Rah ,  Tae-Sik Nam ,  Byung-Ju Kim ,  Gul Rukhsana

发明人： Uh-Hyun Kim ,  Ho-Jeong Kwon ,  Mie-Jae Im ,  Seon-Young Kim ,  Kwang-Hyun Park ,  So-Young Rah ,  Tae-Sik Nam ,  Byung-Ju Kim ,  Gul Rukhsana

IPC分类号： A61K31/655 ,  A61P13/12 ,  A61K31/05 ,  A61P9/00

CPC分类号： C07C245/08 ,  C07C39/215

摘要： The present disclosure relates to bisphenyl compounds that are useful for inhibiting the ADP-ribosyl cyclase (ADPR-cyclase). More particularly, the disclosed compounds can be used for treatment and prevention of hypertension, hypertensive cardiac hypertrophy, diabetes, and diabetic nephropathy, in which pathogenesis ADPR-cyclase is involved. The compounds and compositions of the invention can be used for treatment and prevention of cardiovascular disease and related disease states, particularly, hypertension or diabetes related disorders, such as, hypertensive cardiac hypertrophy, diabetic nephropathy, and the like.

摘要翻译： 本公开涉及可用于抑制ADP-核糖基环化酶（ADPR-环化酶）的双苯基化合物。 更具体地，所公开的化合物可用于治疗和预防涉及发病机制ADPR-环化酶的高血压，高血压心脏肥大，糖尿病和糖尿病性肾病。 本发明的化合物和组合物可用于治疗和预防心血管疾病和相关疾病状态，特别是高血压或糖尿病相关疾病，例如高血压心脏肥大，糖尿病性肾病等。

公开(公告)号：US20110039919A1

公开(公告)日：2011-02-17

申请号：US12865356

申请日：2009-01-30

申请人： Ho Jeong Kwon ,  Hye Jin Jung

发明人： Ho Jeong Kwon ,  Hye Jin Jung

IPC分类号： A61K31/381 ,  A61P9/10 ,  A61P17/06 ,  A61P35/00 ,  A61P29/00 ,  A61P27/02 ,  A61P37/06 ,  A61P25/28 ,  A61P17/02 ,  A61P1/16 ,  A61P3/10

CPC分类号： A61K31/381

摘要： Provided is a pharmaceutical composition for inhibiting angiogenesis, comprising a therapeutically effective amount of a compound represented by Formula 1: (I) wherein R1 through R13 and X are as defined in the specification. Compounds used as an active ingredient in the pharmaceutical composition of the present invention bind to QP-C to provide effective prevention of angiogenesis and can be effectively used for prevention and/or treatment of angiogenesis-related diseases or disorders. Further, the active compounds of the present invention inhibit biological functions of QP-C, which consequently leads to inhibition of angiogenic responses without the risk of cellular apoptosis, thus significantly improving safety of the drug.

摘要翻译： 本发明提供一种抑制血管生成的药物组合物，其含有治疗有效量的式1表示的化合物：（Ⅰ）其中R1至R13和X如说明书中所定义。 在本发明的药物组合物中用作活性成分的化合物与QP-C结合以提供有效的血管发生预防，并可有效地用于预防和/或治疗血管发生相关疾病或病症。 此外，本发明的活性化合物抑制QP-C的生物学功能，其结果导致血管生成反应的抑制而没有细胞凋亡的风险，因此显着提高了药物的安全性。