公开(公告)号：US20110039919A1

公开(公告)日：2011-02-17

申请号：US12865356

申请日：2009-01-30

申请人： Ho Jeong Kwon ,  Hye Jin Jung

发明人： Ho Jeong Kwon ,  Hye Jin Jung

IPC分类号： A61K31/381 ,  A61P9/10 ,  A61P17/06 ,  A61P35/00 ,  A61P29/00 ,  A61P27/02 ,  A61P37/06 ,  A61P25/28 ,  A61P17/02 ,  A61P1/16 ,  A61P3/10

CPC分类号： A61K31/381

摘要： Provided is a pharmaceutical composition for inhibiting angiogenesis, comprising a therapeutically effective amount of a compound represented by Formula 1: (I) wherein R1 through R13 and X are as defined in the specification. Compounds used as an active ingredient in the pharmaceutical composition of the present invention bind to QP-C to provide effective prevention of angiogenesis and can be effectively used for prevention and/or treatment of angiogenesis-related diseases or disorders. Further, the active compounds of the present invention inhibit biological functions of QP-C, which consequently leads to inhibition of angiogenic responses without the risk of cellular apoptosis, thus significantly improving safety of the drug.

摘要翻译： 本发明提供一种抑制血管生成的药物组合物，其含有治疗有效量的式1表示的化合物：（Ⅰ）其中R1至R13和X如说明书中所定义。 在本发明的药物组合物中用作活性成分的化合物与QP-C结合以提供有效的血管发生预防，并可有效地用于预防和/或治疗血管发生相关疾病或病症。 此外，本发明的活性化合物抑制QP-C的生物学功能，其结果导致血管生成反应的抑制而没有细胞凋亡的风险，因此显着提高了药物的安全性。

公开(公告)号：US09371286B2

公开(公告)日：2016-06-21

申请号：US14232598

申请日：2011-05-23

申请人： Ho Jeong Kwon ,  Gyoon Hee Han ,  Hye Jin Jung ,  Jeong Jea Seo

发明人： Ho Jeong Kwon ,  Gyoon Hee Han ,  Hye Jin Jung ,  Jeong Jea Seo

IPC分类号： C07D215/38 ,  C07C311/21 ,  C07C311/20

CPC分类号： C07D215/38 ,  C07C311/20 ,  C07C311/21 ,  C07C2601/14

摘要： The present invention relates to a pharmaceutical composition for inhibiting angiogenesis and a novel sulfonyl amide derivative compound which can be useful for the prevention or treatment of angiogenesis-related diseases or disorders. Since the compound used as an active ingredient in the pharmaceutical composition of the invention is specifically bound to UQCRB and inhibits biological functions thereof, apoptosis is not induced and angiogenic responses are inhibited. Therefore, the compound used as an active ingredient in the pharmaceutical composition of the invention can be useful as an effective and safe angiogenesis inhibitory agent.

摘要翻译： 本发明涉及一种抑制血管发生的药物组合物和一种可用于预防或治疗血管生成相关疾病或病症的新型磺酰基酰胺衍生物化合物。 由于用作本发明的药物组合物中的活性成分的化合物与UQCRB特异性结合并抑制其生物学功能，因此不诱导细胞凋亡并且抑制血管生成反应。 因此，本发明的药物组合物中作为活性成分使用的化合物可用作有效且安全的血管生成抑制剂。

公开(公告)号：US08450502B2

公开(公告)日：2013-05-28

申请号：US12865356

申请日：2009-01-30

申请人： Ho Jeong Kwon ,  Hye Jin Jung

发明人： Ho Jeong Kwon ,  Hye Jin Jung

IPC分类号： C07D333/50 ,  A61P35/00

CPC分类号： A61K31/381

摘要： Provided is a pharmaceutical composition for inhibiting angiogenesis, comprising a therapeutically effective amount of a compound represented by Formula 1: (I) wherein R1 through R13 and X are as defined in the specification. Compounds used as an active ingredient in the pharmaceutical composition of the present invention bind to QP-C to provide effective prevention of angiogenesis and can be effectively used for prevention and/or treatment of angiogenesis-related diseases or disorders. Further, the active compounds of the present invention inhibit biological functions of QP-C, which consequently leads to inhibition of angiogenic responses without the risk of cellular apoptosis, thus significantly improving safety of the drug.

摘要翻译： 本发明提供一种抑制血管生成的药物组合物，其含有治疗有效量的式1表示的化合物：（Ⅰ）其中R1至R13和X如说明书中所定义。 在本发明的药物组合物中用作活性成分的化合物与QP-C结合以提供有效的血管发生预防，并可有效地用于预防和/或治疗血管发生相关疾病或病症。 此外，本发明的活性化合物抑制QP-C的生物学功能，其结果导致血管生成反应的抑制而没有细胞凋亡的风险，因此显着提高了药物的安全性。

公开(公告)号：US20140315947A1

公开(公告)日：2014-10-23

申请号：US14232598

申请日：2011-05-23

申请人： Ho Jeong Kwon ,  Gyoon Hee Han ,  Hye Jin Jung ,  Jeong Jea Seo

发明人： Ho Jeong Kwon ,  Gyoon Hee Han ,  Hye Jin Jung ,  Jeong Jea Seo

IPC分类号： C07D215/38 ,  C07C311/21

CPC分类号： C07D215/38 ,  C07C311/20 ,  C07C311/21 ,  C07C2601/14

摘要： The present invention relates to a pharmaceutical composition for inhibiting angiogenesis and a novel sulfonyl amide derivative compound which can be useful for the prevention or treatment of angiogenesis-related diseases or disorders. Since the compound used as an active ingredient in the pharmaceutical composition of the invention is specifically bound to UQCRB and inhibits biological functions thereof, apoptosis is not induced and angiogenic responses are inhibited. Therefore, the compound used as an active ingredient in the pharmaceutical composition of the invention can be useful as an effective and safe angiogenesis inhibitory agent.

摘要翻译： 本发明涉及一种抑制血管发生的药物组合物和一种可用于预防或治疗血管生成相关疾病或病症的新型磺酰基酰胺衍生物化合物。 由于用作本发明的药物组合物中的活性成分的化合物与UQCRB特异性结合并抑制其生物学功能，因此不诱导细胞凋亡并且抑制血管生成反应。 因此，本发明的药物组合物中作为活性成分使用的化合物可用作有效且安全的血管生成抑制剂。

公开(公告)号：US20070173703A1

公开(公告)日：2007-07-26

申请号：US11475053

申请日：2006-06-27

申请人： Kwang Hyeon Lee ,  Hye Jin Jung ,  Sang Hoon Shin ,  Kyung Ho Kim

发明人： Kwang Hyeon Lee ,  Hye Jin Jung ,  Sang Hoon Shin ,  Kyung Ho Kim

IPC分类号： A61B5/00

CPC分类号： G01G19/4146 ,  G06F19/3475

摘要： A method of managing weight by using calorie consumption information, the method including: receiving target information from a user; receiving calorie consumption data of the user; analyzing the calorie consumption data based on the target information; and providing feedback to the user for a result of the analyzing the calorie consumption data.

摘要翻译： 一种通过使用卡路里消耗信息来管理权重的方法，所述方法包括：从用户接收目标信息; 接收用户的热量消耗数据; 基于目标信息分析卡路里消耗数据; 并且为了分析卡路里消耗数据的结果向用户提供反馈。

公开(公告)号：US08301215B2

公开(公告)日：2012-10-30

申请号：US11819923

申请日：2007-06-29

申请人： Jong Youn Lee ,  Kenichi Yamakoshi ,  Kun Soo Shin ,  Hye Jin Jung ,  Shinobu Tanaka ,  Takehiro Yamakoshi

发明人： Jong Youn Lee ,  Kenichi Yamakoshi ,  Kun Soo Shin ,  Hye Jin Jung ,  Shinobu Tanaka ,  Takehiro Yamakoshi

IPC分类号： A61B5/1455 ,  A61B5/02

CPC分类号： A61B5/14552 ,  A61B5/022 ,  A61B5/024 ,  A61B5/681 ,  A61B5/6843 ,  A61B2562/0233 ,  A61B2562/046

摘要： A biosignal measurement apparatus including: a bracelet membrane to wear around a user's wrist; a fixing supporter to install in a first side portion of the bracelet membrane and to support a first side portion of the wrist; a moving supporter to install in a second side portion of the bracelet membrane, to move towards the fixing supporter, and closely to attach to a second side portion of the wrist; and an information control unit to calculate a distance between the first side portion of the wrist and the second side portion of the wrist by detecting a movement distance of the moving supporter, and to calculate a displacement of the radial artery of the wrist by using a predetermined constant and the calculated distance between the first side portion of the wrist and the second side portion of the wrist.

摘要翻译： 一种生物信号测量装置，包括：用于使用者手腕周围佩戴的手镯膜; 固定支撑件，其安装在手镯膜的第一侧部分中并支撑手腕的第一侧部; 移动的支撑件，以安装在手镯膜的第二侧部中，朝向固定支撑件移动，并且紧密地附接到手腕的第二侧部; 以及信息控制单元，通过检测移动支撑件的移动距离来计算手腕的第一侧部与手腕的第二侧部之间的距离，并且通过使用 预定的常数和计算出的手腕的第一侧部分与手腕的第二侧面部分之间的距离。