公开(公告)号：US06653086B1

公开(公告)日：2003-11-25

申请号：US09364425

申请日：1999-07-30

Applicant: Dominic P. Behan ,  Derek T. Chalmers ,  Chen W. Liaw ,  I Lin-Lin ,  Kevin P. Lowitz ,  Ruoping Chen

Inventor： Dominic P. Behan ,  Derek T. Chalmers ,  Chen W. Liaw ,  I Lin-Lin ,  Kevin P. Lowitz ,  Ruoping Chen

IPC: C12N1500

CPC classification number: C07D231/12 ,  C07D231/16 ,  C07D233/42 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D513/04 ,  C07K14/70571 ,  G01N33/68 ,  G01N2500/00

Abstract: Disclosed herein are techniques for directly identifying candidate compounds as agonists, partial agonists and/or, most preferably, inverse agonists, to endogenous, constitutively activated orphan G protein-coupled receptors. Such directly identified compounds can be utilized, most preferably, in pharmaceutical compositions

Abstract translation: 本文公开了用于直接鉴定候选化合物作为内源性，组成型激活的孤儿G蛋白偶联受体的激动剂，部分激动剂和/或最优选的反向激动剂的技术。 这种直接鉴定的化合物可以最优选地用于药物组合物中

公开(公告)号：US07381522B2

公开(公告)日：2008-06-03

申请号：US11404939

申请日：2006-04-14

Applicant: Karin Lehmann-Bruinsma ,  Chen W. Liaw ,  I-Lin Lin

Inventor： Karin Lehmann-Bruinsma ,  Chen W. Liaw ,  I-Lin Lin

IPC: C12Q1/00 ,  G01N33/53 ,  G01N33/566

CPC classification number: G01N33/74 ,  A61K38/00 ,  C07K14/705 ,  C07K14/723 ,  C07K2319/00 ,  G01N2333/726 ,  G01N2500/10

Abstract: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is known (“known GPCRs”), and most particularly to mutated (non-endogenous) versions of the known GPCRs for use, most preferably in screening assays for the direct identification of candidate compounds as inverse agonists, agonists and partial agonists.

Abstract translation: 本专利文献中公开的发明涉及跨膜受体，更具体地涉及内源性配体已知的人G蛋白偶联受体（“已知的GPCR”），最特别地涉及已知的突变的（非内源的）版本 GPCRs，最优选用于直接鉴定作为反向激动剂，激动剂和部分激动剂的候选化合物的筛选试验。

公开(公告)号：US20070122878A1

公开(公告)日：2007-05-31

申请号：US11417708

申请日：2006-05-04

Applicant: Ruoping Chen ,  Huong Dang ,  Chen Liaw ,  I-Lin Lin

Inventor： Ruoping Chen ,  Huong Dang ,  Chen Liaw ,  I-Lin Lin

IPC: C07K14/705 ,  C07H21/04 ,  C12P21/06

CPC classification number: C07K14/723 ,  C07K14/705 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/02

Abstract: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors.

Abstract translation: 本专利文献中公开的发明涉及跨膜受体，更具体地涉及内源性，孤儿G蛋白偶联受体。