公开(公告)号：US08198049B2

公开(公告)日：2012-06-12

申请号：US12958954

申请日：2010-12-02

Applicant: Ruoping Chen ,  Huong T. Dang ,  Chen W. Liaw ,  I-Lin Lin

Inventor： Ruoping Chen ,  Huong T. Dang ,  Chen W. Liaw ,  I-Lin Lin

IPC: C12P21/06 ,  G01N33/53 ,  G01N33/567 ,  C12N1/20 ,  C12N15/00 ,  C12N5/00 ,  C12N5/02 ,  C12N15/74 ,  C07H21/02 ,  C07H21/04 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00

CPC classification number: C07K14/723 ,  C07K14/705 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/02

Abstract: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors.

Abstract translation: 本专利文献中公开的发明涉及跨膜受体，更具体地涉及内源性，孤儿G蛋白偶联受体。

公开(公告)号：US20110195431A1

公开(公告)日：2011-08-11

申请号：US12958954

申请日：2010-12-02

Applicant: Ruoping Chen ,  Huong T. Dang ,  Chen W. Liaw ,  I-Lin LIn

Inventor： Ruoping Chen ,  Huong T. Dang ,  Chen W. Liaw ,  I-Lin LIn

IPC: G01N33/53 ,  C12N15/12 ,  C12N15/63 ,  C12N5/07 ,  C12Q1/02 ,  C12P21/00

CPC classification number: C07K14/723 ,  C07K14/705 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/02

Abstract: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors.

Abstract translation: 本专利文献中公开的发明涉及跨膜受体，更具体地涉及内源性，孤儿G蛋白偶联受体。

公开(公告)号：US20060183164A1

公开(公告)日：2006-08-17

申请号：US11404939

申请日：2006-04-14

Applicant: Karin Lehmann-Bruinsma ,  Chen Liaw ,  I-Lin Lin

Inventor： Karin Lehmann-Bruinsma ,  Chen Liaw ,  I-Lin Lin

IPC: G01N33/567 ,  G01N33/53

CPC classification number: G01N33/74 ,  A61K38/00 ,  C07K14/705 ,  C07K14/723 ,  C07K2319/00 ,  G01N2333/726 ,  G01N2500/10

Abstract: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is known (“known GPCRs”), and most particularly to mutated (non-endogenous) versions of the known GPCRs for use, most preferably in screening assays for the direct identification of candidate compounds as inverse agonists, agonists and partial agonists.

公开(公告)号：US06806054B2

公开(公告)日：2004-10-19

申请号：US09826509

申请日：2001-04-05

Applicant: Karin Lehmann-Bruinsma ,  Chen W. Liaw ,  I-Lin Lin

Inventor： Karin Lehmann-Bruinsma ,  Chen W. Liaw ,  I-Lin Lin

IPC: G01N3353

CPC classification number: G01N33/74 ,  A61K38/00 ,  C07K14/705 ,  C07K14/723 ,  C07K2319/00 ,  G01N2333/726 ,  G01N2500/10

Abstract: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is known (“known GPCRs”), and most particularly to mutated (non-endogenous) versions of the known GPCRs for use, most preferably in screening assays for the direct identification of candidate compounds as inverse agonists, agonists and partial agonists.

Abstract translation: 本专利文献中公开的发明涉及跨膜受体，更具体地涉及内源性配体已知的人G蛋白偶联受体（“已知的GPCR”），最特别地涉及已知的突变的（非内源的）版本 GPCRs，最优选用于直接鉴定作为反向激动剂，激动剂和部分激动剂的候选化合物的筛选试验。

公开(公告)号：US20080199889A1

公开(公告)日：2008-08-21

申请号：US11894692

申请日：2007-08-20

Applicant: Ruoping Chen ,  Huong T. Dang ,  Chen W. Liaw ,  I-Lin Lin

Inventor： Ruoping Chen ,  Huong T. Dang ,  Chen W. Liaw ,  I-Lin Lin

IPC: G01N33/53 ,  C07H21/04 ,  C12N15/00 ,  C12P21/04 ,  C12N5/00

CPC classification number: C07K14/723 ,  C07K14/705 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/02

Abstract: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors.

Abstract translation: 本专利文献中公开的发明涉及跨膜受体，更具体地涉及内源性，孤儿G蛋白偶联受体。

公开(公告)号：US20060240523A1

公开(公告)日：2006-10-26

申请号：US11479174

申请日：2006-06-30

Applicant: Chen Liaw ,  Derek Chalmers ,  Dominic Behan ,  Dominique Maciejewski-Lenior ,  James Leonard ,  I-Lin Lin ,  Daniel Ortuno

Inventor： Chen Liaw ,  Derek Chalmers ,  Dominic Behan ,  Dominique Maciejewski-Lenior ,  James Leonard ,  I-Lin Lin ,  Daniel Ortuno

IPC: C07K14/705 ,  C07H21/04 ,  C12P21/06

CPC classification number: C07K14/70571 ,  C07K14/723 ,  G01N33/566 ,  G01N2333/70571 ,  G01N2333/726

Abstract: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor and to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.

公开(公告)号：US07893235B2

公开(公告)日：2011-02-22

申请号：US11894692

申请日：2007-08-20

Applicant: Ruoping Chen ,  Huong T. Dang ,  Chen W. Liaw ,  I-Lin Lin

Inventor： Ruoping Chen ,  Huong T. Dang ,  Chen W. Liaw ,  I-Lin Lin

IPC: C07H21/04 ,  G01N33/53 ,  G01N33/567 ,  C12P21/06 ,  C12N1/20 ,  C12N15/00 ,  C12N5/00 ,  C12N5/02 ,  C12N15/74

CPC classification number: C07K14/723 ,  C07K14/705 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/02

Abstract: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors.

Abstract translation: 本专利文献中公开的发明涉及跨膜受体，更具体地涉及内源性，孤儿G蛋白偶联受体。

公开(公告)号：US07119190B2

公开(公告)日：2006-10-10

申请号：US10083168

申请日：2002-02-26

Applicant: Chen W. Liaw ,  Derek T. Chalmers ,  Dominic P. Behan ,  Dominique Maciejewski-Lenior ,  James N. Leonard ,  I-Lin Lin ,  Daniel Ortuño

Inventor： Chen W. Liaw ,  Derek T. Chalmers ,  Dominic P. Behan ,  Dominique Maciejewski-Lenior ,  James N. Leonard ,  I-Lin Lin ,  Daniel Ortuño

IPC: C07H21/04 ,  C12N15/63 ,  C12N15/09

CPC classification number: C07D231/12 ,  A61K38/00 ,  C07D231/16 ,  C07D409/12 ,  C07K14/705 ,  C07K14/70571 ,  C07K14/723 ,  G01N33/566 ,  G01N2333/70571 ,  G01N2333/726

Abstract: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor and to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.

公开(公告)号：US07097969B2

公开(公告)日：2006-08-29

申请号：US10925095

申请日：2004-08-24

Applicant: Karin Lehmann-Bruinsma ,  Chen W. Liaw ,  I-Lin Lin

Inventor： Karin Lehmann-Bruinsma ,  Chen W. Liaw ,  I-Lin Lin

IPC: C12Q1/00 ,  G01N33/53 ,  G01N33/566

CPC classification number: G01N33/74 ,  A61K38/00 ,  C07K14/705 ,  C07K14/723 ,  C07K2319/00 ,  G01N2333/726 ,  G01N2500/10

Abstract: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is known (“known GPCRs”), and most particularly to mutated (non-endogenous) versions of the known GPCRs for use, most preferably in screening assays for the direct identification of candidate compounds as inverse agonists, agonists and partial agonists.

公开(公告)号：US20050019840A1

公开(公告)日：2005-01-27

申请号：US10925095

申请日：2004-08-24

Applicant: Karin Lehmann-Bruinsma ,  Chen Liaw ,  I-Lin Lin

Inventor： Karin Lehmann-Bruinsma ,  Chen Liaw ,  I-Lin Lin

IPC: G01N33/50 ,  A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C12N15/12 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/53 ,  G01N33/567

CPC classification number: G01N33/74 ,  A61K38/00 ,  C07K14/705 ,  C07K14/723 ,  C07K2319/00 ,  G01N2333/726 ,  G01N2500/10

Abstract: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is known (“known GPCRs”), and most particularly to mutated (non-endogenous) versions of the known GPCRs for use, most preferably in screening assays for the direct identification of candidate compounds as inverse agonists, agonists and partial agonists.

Abstract translation: 本专利文献中公开的发明涉及跨膜受体，更具体地涉及内源性配体已知的人G蛋白偶联受体（“已知的GPCR”），最特别地涉及已知的突变的（非内源的）版本 GPCRs，最优选用于直接鉴定作为反向激动剂，激动剂和部分激动剂的候选化合物的筛选试验。