中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

23 records (took 0.025 seconds)

    Modified Release Dosage Forms of Skeletal Muscle Relaxants
    11.
    发明申请
    Modified Release Dosage Forms of Skeletal Muscle Relaxants 有权
    骨骼肌松弛剂的改性释放剂量形式

    公开(公告)号：US20090017126A1

    公开(公告)日：2009-01-15

    申请号：US12236719

    申请日：2008-09-24

    Applicant: Gopi Venkatesh ,  James M. Clevenger

    Inventor： Gopi Venkatesh ,  James M. Clevenger

    IPC: A61K9/50 ,  A61P21/02

    CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/5078 ,  A61K31/137 ,  A61K31/5513 ,  Y10T29/49826

    Abstract: A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once-daily oral administration to maintain an adequate plasma concentration—time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.

    Abstract translation: 用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒， 颗粒等）。 至少一个珠粒表现出预先设计的持续释放特征。 这种药物递送系统设计为每日一次口服给药以维持足够的血浆浓度 - 时间特征，从而在24小时内缓解与疼痛的肌肉骨骼病症相关的肌肉痉挛。

    Radiation cured drug release controlling membrane
    12.
    发明授权
    Radiation cured drug release controlling membrane 失效
    放射治疗药物释放控制膜

    公开(公告)号：US5532287A

    公开(公告)日：1996-07-02

    申请号：US238115

    申请日：1994-05-04

    Applicant: Gary V. Savage ,  James M. Clevenger

    Inventor： Gary V. Savage ,  James M. Clevenger

    IPC: A61K9/28 ,  C08F2/46 ,  C08J3/28

    CPC classification number: C08J3/28 ,  A61K9/2866 ,  C08J2301/28

    Abstract: This invention pertains to cross-linked hydrophilic polymeric films, the process of making such films, and their use. The films of this invention are produced by solubilizing a water-soluble polymer with a photosensitive or light degradable catalyst, optionally drying said solution, and exposing the solution to an energy source, particularly light. These films are suitable for use as a carrier for biologically active agents, such as pharmaceuticals, both human and veterinary, insecticides, and fertilizers; as hydrophilic membranes for separation processes; as bandages for wound treatment; as body implants or as coatings for such implants; and as coatings on glass, metal, wood or ceramics.

    Abstract translation: 本发明涉及交联的亲水聚合物膜，制备这种膜的方法及其用途。 本发明的膜通过用光敏或光可降解催化剂溶解水溶性聚合物，任选地干燥所述溶液，并将溶液暴露于能源，特别是光来制备。 这些膜适合用作生物活性剂的载体，例如药物，人和兽医，杀虫剂和肥料; 作为分离过程的亲水膜; 作为伤口治疗的绷带; 作为身体植入物或作为这种植入物的涂层; 以及作为玻璃，金属，木材或陶瓷上的涂层。

    Supercritical fluid and near critical gas extraction of organic solvents from formed articles
    13.
    发明授权
    Supercritical fluid and near critical gas extraction of organic solvents from formed articles 失效
    超临界流体和成型制品中有机溶剂的临界气体萃取

    公开(公告)号：US5287632A

    公开(公告)日：1994-02-22

    申请号：US557283

    申请日：1990-07-24

    Applicant: Lawrence B. Heit ,  James M. Clevenger

    Inventor： Lawrence B. Heit ,  James M. Clevenger

    IPC: A61K9/20 ,  A61K9/00 ,  A61K9/28 ,  B01D11/02 ,  B01J3/00 ,  B01J8/00 ,  B01J8/02 ,  B01J15/00 ,  F26B3/00

    CPC classification number: B01D11/0203 ,  A61K9/0004 ,  A61K9/28

    Abstract: Disclosed is a method of removing residual organic solvents from formed compressed articles such as tablets comprised of subjecting the organic solvent laden compressed article to a supercritical fluid or near critical gas whereby residual solvent is transferred from the solvent laden solid article to the supercritical fluid or near critical gas and separating the residual solvent depleted compressed article from the solvent enriched supercritical fluid or near critical gas.

    Abstract translation: 公开了一种从形成的压缩制品例如片剂中除去残留的有机溶剂的方法，所述片剂包括将含有载体的压缩制品置于超临界流体或临界气体附近，由此将残留溶剂从载有溶剂的固体制品转移至超临界流体或接近 关键气体，并将富含残留溶剂的压缩制品与富含溶剂的超临界流体或临界气体相接近。

    RAPIDLY DISPERSING GRANULES, ORALLY DISINTEGRATING TABLETS AND METHODS
    14.
    发明申请
    RAPIDLY DISPERSING GRANULES, ORALLY DISINTEGRATING TABLETS AND METHODS 审中-公开
    快速分散颗粒，ORALLY DISPATTING DISPATTING AND METHODS

    公开(公告)号：US20120282335A1

    公开(公告)日：2012-11-08

    申请号：US13310632

    申请日：2011-12-02

    Applicant: Gopi M. Venkatesh ,  Vijaya Swaminathan ,  Jin-Wang Lai ,  James M. Clevenger

    Inventor： Gopi M. Venkatesh ,  Vijaya Swaminathan ,  Jin-Wang Lai ,  James M. Clevenger

    IPC: A61K9/14 ,  A61K31/445 ,  A61K31/485 ,  A61K9/20 ,  A61K31/167

    Abstract: This invention relates to rapidly dispersing microgranules comprising at least one sugar alcohol or saccharide, at least one super disintegrant, and a pharmaceutically acceptable additive with multi-functionality (e.g., starch acting as a binder, disintegrant, diluent/filler, glidant, etc) at a low level, which can be formed by not only eliminating a wet milling step but also avoiding an extensive dry milling step. Furthermore, such rapidly dispersing microgranules could also comprise a pharmaceutically active agent thereby providing for a pharmaceutical composition, or the rapidly dispersing microgranules thus produced are suitable for blending with a pharmaceutically active agent that is optionally taste-masked and/or controlled release coated microparticles to also provide for a pharmaceutical composition and the invention is also directed to a method for manufacturing such rapidly dispersing microgranules in a high useable yield, as well as orally disintegrating tablets comprising such rapidly dispersing microgranules. The rapidly dispersing microgranules are also free flowing.

    Abstract translation: 本发明涉及快速分散包含至少一种糖醇或糖，至少一种超级崩解剂和具有多官能度的药学上可接受的添加剂（例如，作为粘合剂的淀粉，崩解剂，稀释剂/填充剂，助流剂等）的微粒体， 在低水平，其可以通过不仅消除湿磨步骤而且可以避免广泛的干磨步骤形成。 此外，这种快速分散的微粒还可以包含药物活性剂，从而提供药物组合物，或由此制备的快速分散的微粒适合于与任选地掩蔽和/或控释的微粒的药物活性剂混合， 还提供药物组合物，并且本发明还涉及以高可用产率制造这种快速分散的微粒的方法，以及包含这种快速分散的微粒的口腔崩解片。 快速分散的微粒也是自由流动的。

    MODIFIED RELEASE DOSAGE FORMS OF SKELETAL MUSCLE RELAXANTS
    18.
    发明申请
    MODIFIED RELEASE DOSAGE FORMS OF SKELETAL MUSCLE RELAXANTS 有权
    修饰释放剂量的骨骼肌松弛剂

    公开(公告)号：US20080124399A1

    公开(公告)日：2008-05-29

    申请号：US12026887

    申请日：2008-02-06

    Applicant: GOPI VENKATESH ,  James M. Clevenger

    Inventor： GOPI VENKATESH ,  James M. Clevenger

    IPC: A61K9/14 ,  A61K31/135 ,  A61P21/02

    CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/5078 ,  A61K31/137 ,  A61K31/5513 ,  Y10T29/49826

    Abstract: A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once-daily oral administration to maintain an adequate plasma concentration-time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.

    Abstract translation: 用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒， 颗粒等）。 至少一个珠粒表现出预先设计的持续释放特征。 这种药物递送系统设计为每日一次口服给药以维持足够的血浆浓度 - 时间特征，从而在24小时内缓解与疼痛的肌肉骨骼病症相关的肌肉痉挛。

Patent Agency Ranking