公开(公告)号：US20080085926A1

公开(公告)日：2008-04-10

申请号：US11906374

申请日：2007-10-02

Applicant: John Stelmach ,  Emma Parmee ,  James Tata ,  Keith Rosauer ,  Ronald Kim ,  Amy Bittner ,  Jiang Chang ,  Christopher Sinz

Inventor： John Stelmach ,  Emma Parmee ,  James Tata ,  Keith Rosauer ,  Ronald Kim ,  Amy Bittner ,  Jiang Chang ,  Christopher Sinz

IPC: A61K31/404 ,  A61P3/04 ,  A61P3/10 ,  A61P9/10 ,  C07D209/04

CPC classification number: C07D209/18

Abstract: Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

Abstract translation: 公开了胰高血糖素受体拮抗剂化合物。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。

公开(公告)号：US5877182A

公开(公告)日：1999-03-02

申请号：US926212

申请日：1997-09-09

Applicant: Ravi Nargund ,  Arthur A. Patchett ,  James Tata

Inventor： Ravi Nargund ,  Arthur A. Patchett ,  James Tata

IPC: C07D401/06 ,  C07D471/10 ,  A61K31/445 ,  C07D221/20

CPC classification number: A61K31/663 ,  C07D401/06 ,  C07D471/10

Abstract: The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein B is selected from: ##STR2## and R.sup.1, R.sup.1a, R.sup.2a, R.sup.3a, R.sup.3b, R.sup.4, R.sup.4a, R.sup.4b, R.sup.5, D,E, X, Y, n, x and y are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

Abstract translation: 本发明涉及以下通式结构式的某些哌啶，吡咯烷和六氢-1H-吖庚因：其中B选自：其中R 1，R 1a，R 2a，R 3a，R 3b，R 4，R 4a， R4b，R5，D，E，X，Y，n，x和y如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人类中，用于治疗以生长激素分泌不足为特征的生理或医学病症，例如生长激素缺乏的身材矮小 儿童，并且治疗通过生长激素的合成代谢作用改善的医疗状况。 还公开了含有这些化合物作为其活性成分的生长激素释放组合物。