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1.发明申请Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权熔融吲哚作为二肽基肽酶抑制剂用于治疗或预防糖尿病公开(公告)号：US20060281796A1
公开(公告)日：2006-12-14
申请号：US10558931
申请日：2004-06-02
IPC分类号： A61K31/427 , A61K31/403 , C07D417/02 , C07D403/02
CPC分类号： C07D209/88 , C07D209/86 , C07D403/06 , C07D417/06
摘要： The present invention is directed to fused indole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的稠合吲哚衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 作为糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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2.发明授权Substituted pyrazoles, compositions containing such compounds and methods of use 有权取代的吡唑，含有这些化合物的组合物和使用方法公开(公告)号：US07989475B2
公开(公告)日：2011-08-02
申请号：US12407184
申请日：2009-03-19
IPC分类号： A61K31/4155 , A61K31/445 , C07D231/10 , C07D401/04
CPC分类号： C07D231/12 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/12 , C07D413/10
摘要： The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
摘要翻译： 本发明涉及取代的吡唑，含有这些化合物的组合物和治疗方法该化合物是胰高血糖素受体拮抗剂，因此可用于治疗，预防或延缓2型糖尿病的发作。
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3.发明申请SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE 有权取代的吡唑，含有这些化合物的组合物和使用方法公开(公告)号：US20090215825A1
公开(公告)日：2009-08-27
申请号：US12407184
申请日：2009-03-19
IPC分类号： A61K31/454 , C07D401/14 , A61K31/4439 , C07D401/04 , A61P3/10
CPC分类号： C07D231/12 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/12 , C07D413/10
摘要： The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
摘要翻译： 本发明涉及取代的吡唑，含有这些化合物的组合物和治疗方法该化合物是胰高血糖素受体拮抗剂，因此可用于治疗，预防或延缓2型糖尿病的发作。
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4.发明授权Substituted pyrazoles, compositions containing such compounds and methods of use 有权取代的吡唑，含有这些化合物的组合物和使用方法公开(公告)号：US07572922B2
公开(公告)日：2009-08-11
申请号：US10543290
申请日：2004-01-23
IPC分类号： C07D257/00 , C07D231/10 , A01N43/64 , A01N43/56
CPC分类号： C07D231/12 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/12 , C07D413/10
摘要： The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
摘要翻译： 本发明涉及取代的吡唑，含有这些化合物的组合物和治疗方法该化合物是胰高血糖素受体拮抗剂，因此可用于治疗，预防或延缓2型糖尿病的发作。
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5.发明申请Pyrazole Amide Derivatives, Compositions Containing Such Compounds And Methods Of Use 失效吡唑酰胺衍生物，含有这些化合物的组合物和使用方法公开(公告)号：US20070203186A1
公开(公告)日：2007-08-30
申请号：US11631580
申请日：2005-07-01
IPC分类号： A61K31/454 , A61K31/341 , A61K31/4152 , C07D237/06 , C07D403/02 , A61K31/4439
CPC分类号： C07D403/12 , C07D231/14 , C07D233/90 , C07D401/06 , C07D401/14 , C07D417/12
摘要： Pyrazole amides are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 披露吡唑酰胺。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。
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6.发明申请Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use 有权胰高血糖素受体拮抗剂化合物，含有这些化合物的组合物和使用方法公开(公告)号：US20080085926A1
公开(公告)日：2008-04-10
申请号：US11906374
申请日：2007-10-02
申请人： John Stelmach , Emma Parmee , James Tata , Keith Rosauer , Ronald Kim , Amy Bittner , Jiang Chang , Christopher Sinz
发明人： John Stelmach , Emma Parmee , James Tata , Keith Rosauer , Ronald Kim , Amy Bittner , Jiang Chang , Christopher Sinz
IPC分类号： A61K31/404 , A61P3/04 , A61P3/10 , A61P9/10 , C07D209/04
CPC分类号： C07D209/18
摘要： Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 公开了胰高血糖素受体拮抗剂化合物。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。
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7.发明申请Cyclic guanidines, compositions containing such compounds and methods of use 有权环状胍，含有这些化合物的组合物和使用方法公开(公告)号：US20070105930A1
公开(公告)日：2007-05-10
申请号：US10580183
申请日：2004-12-15
申请人： Emma Parmee , Ronald Kim , Elizabeth Rouse , Darby Schmidt , Christopher Sinz , Jiang Chang
发明人： Emma Parmee , Ronald Kim , Elizabeth Rouse , Darby Schmidt , Christopher Sinz , Jiang Chang
IPC分类号： A61K31/4184 , C07D235/28
CPC分类号： C07D403/12 , C07D235/30 , C07D409/12
摘要： The present invention relates to cyclic guanidines, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
摘要翻译： 本发明涉及环状胍，含有这些化合物的组合物和处理方法。 该化合物是胰高血糖素受体拮抗剂，因此可用于治疗，预防或延缓2型糖尿病的发作。
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8.发明申请Pyrazole derivatives, compositions containing such compounds and methods of use 审中-公开吡唑衍生物，含有这些化合物的组合物和使用方法公开(公告)号：US20070088070A1
公开(公告)日：2007-04-19
申请号：US11583253
申请日：2006-10-19
申请人： Emma Parmee , Yusheng Xiong , Jian Guo , Linda Brockunier
发明人： Emma Parmee , Yusheng Xiong , Jian Guo , Linda Brockunier
IPC分类号： A61K31/415 , C07D231/12
CPC分类号： C07D231/12
摘要： Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 公开了具有连接的萘基的吡唑。 该化合物可用于治疗2型糖尿病及相关病症。 还包括药物组合物和治疗方法。
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9.发明申请公开(公告)号：US20060270679A1
公开(公告)日：2006-11-30
申请号：US11500252
申请日：2006-08-07
申请人： Scott Edmondson , Michael Fisher , Dooseop Kim , Malcolm Maccoss , Emma Parmee , Ann Weber , Jinyou Xu
发明人： Scott Edmondson , Michael Fisher , Dooseop Kim , Malcolm Maccoss , Emma Parmee , Ann Weber , Jinyou Xu
IPC分类号： A61K31/498 , C07D487/04
CPC分类号： A61K31/4985 , A61K31/498 , A61K38/28 , A61K45/06 , C07D487/04 , Y10S514/866 , A61K2300/00
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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公开(公告)号：US07098239B2
公开(公告)日：2006-08-29
申请号：US10481319
申请日：2002-06-19
申请人： Scott D. Edmondson , Emma Parmee , Ann E. Weber , Jinyou Xu
发明人： Scott D. Edmondson , Emma Parmee , Ann E. Weber , Jinyou Xu
IPC分类号： A61K31/40 , C07D207/00
CPC分类号： C07D207/16 , C07D207/26 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/06 , C07D401/12 , C07D403/12 , C07D409/06 , C07D413/12 , C07D417/12
摘要： Compounds having Formula I, including pharmaceutically acceptable salts and prodrugs thereof: (Formula I) are inhibitors of the dipep tidyl peptidase-IV enzyme (DP-IV), and are useful in the treatment of DP-IV mediated diseases and conditions, such as non-insulin dependent diabetes mellitus.
摘要翻译： 具有式I的化合物，包括其药学上可接受的盐和前药：（式I）是二肽基肽酶-IV酶（DP-IV）的抑制剂，可用于治疗DP-IV介导的疾病和病症，例如 非胰岛素依赖性糖尿病。
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