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公开(公告)号：US20070154516A1
公开(公告)日：2007-07-05
申请号：US11617199
申请日：2006-12-28
申请人： Jonathan Bortz , R. Levinson
发明人： Jonathan Bortz , R. Levinson
IPC分类号： A61K31/7048 , A61K31/7034 , A61K31/496 , A61K31/43 , A61K31/545
CPC分类号： A61K9/0034 , A61K9/06 , A61K31/00 , A61K31/43 , A61K31/496 , A61K31/545 , A61K31/7034 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition comprises a first active (e.g., antibacterial) agent and a second (e.g., antifungal) active agent, and comprises a component that is adapted for bioadhesion to a vulvovaginal surface. The composition provides differential release of the active agents at such a surface, wherein the second active agent exhibits a release profile that is substantially delayed, extended and/or inverted relative to the release profile of the first active agent.
摘要翻译： 药物组合物包含第一活性（例如抗细菌剂）和第二（例如抗真菌）活性剂，并且包含适于生物粘附到外阴阴道表面的组分。 组合物在这样的表面提供活性剂的差异释放，其中第二活性剂表现出相对于第一活性剂的释放曲线基本上延迟，延伸和/或翻转的释放特性。
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公开(公告)号：US20060140990A1
公开(公告)日：2006-06-29
申请号：US11326979
申请日：2006-01-05
申请人： Jonathan Bortz , R. Levinson , Mitchell Kirschner , Robert Cuca
发明人： Jonathan Bortz , R. Levinson , Mitchell Kirschner , Robert Cuca
IPC分类号： A61K31/7034 , A61K9/00
CPC分类号： A61K31/7056 , A61K9/0034 , A61K31/00 , A61K31/4174 , A61K31/56 , A61K31/7034 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition comprises (a) an antibacterial agent in an antibacterially effective amount, illustratively comprising clindamycin or a pharmaceutically acceptable salt or ester thereof, and (b) an antifungal agent in an antifungally effective amount, illustratively comprising butoconazole or a pharmaceutically acceptable salt or ester thereof. The composition is adapted for application in a unit dose amount to a vulvovaginal surface and has at least one nonlipoidal internal phase and at least one lipoidal external phase that is bioadhesive to the vulvovaginal surface. The composition is useful for administration to a vulvovaginal surface to treat a mixed bacterial vaginosis and vulvovaginal candidiasis infection.
摘要翻译： 药物组合物包含（a）抗菌活性量的抗菌剂，例如包括克林霉素或其药学上可接受的盐或酯，和（b）抗真菌有效量的抗真菌剂，例如包括布可康唑或其药学上可接受的盐或 的酯。 该组合物适用于以外阴阴道表面的单位剂量施用，并且具有至少一个非脂性内相和至少一个与外阴阴道表面生物粘附的脂质外相。 该组合物可用于给予外阴阴道表面以治疗混合的细菌性阴道炎和外阴阴道念珠菌病感染。
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公开(公告)号：US08425956B2
公开(公告)日：2013-04-23
申请号：US13189893
申请日：2011-07-25
IPC分类号： A23L1/305
CPC分类号： A23L33/175 , A23L33/16 , A23L33/165 , A23V2002/00 , A23V2250/1592 , A23V2250/1628 , A23V2250/044 , A23V2250/061 , A23V2250/0622
摘要： Mixed amino acid/mineral compounds can include at least two amino acids bound to a central mineral atom. The combination of amino acids can be tailored to provide improved solubility, absorption, and/or bioavailability of the mineral. Optionally, organic acids can be bound to the mineral or combined with the chelate in order to further improve solubility, absorption, and/or bioavailability. Compositions including one or more mixed amino acid/mineral compounds can be included in therapeutic regimens for indications in which the mineral may treat and/or prevent a condition or symptom.
摘要翻译： 混合的氨基酸/矿物化合物可包括与中心矿物原子结合的至少两个氨基酸。 可以调整氨基酸的组合以提供矿物质的改善的溶解度，吸收和/或生物利用度。 任选地，有机酸可以与矿物结合或与螯合物结合，以进一步改善溶解度，吸收和/或生物利用度。 包括一种或多种混合氨基酸/矿物化合物的组合物可以包括在用于矿物可以治疗和/或预防病症或症状的适应症的治疗方案中。
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公开(公告)号：US08007846B2
公开(公告)日：2011-08-30
申请号：US11623476
申请日：2007-01-16
IPC分类号： A23L1/304
CPC分类号： A23L33/175 , A23L33/16 , A23L33/165 , A23V2002/00 , A23V2250/1592 , A23V2250/1628 , A23V2250/044 , A23V2250/061 , A23V2250/0622
摘要： Mixed amino acid/mineral compounds can include at least two amino acids bound to a central mineral atom. The combination of amino acids can be tailored to provide improved solubility, absorption, and/or bioavailability of the mineral. Optionally, organic acids can be bound to the mineral or combined with the chelate in order to further improve solubility, absorption, and/or bioavailability. Compositions including one or more mixed amino acid/mineral compounds can be included in therapeutic regimens for indications in which the mineral may treat and/or prevent a condition or symptom.
摘要翻译： 混合的氨基酸/矿物化合物可包括与中心矿物原子结合的至少两个氨基酸。 可以调整氨基酸的组合以提供矿物质的改善的溶解度，吸收和/或生物利用度。 任选地，有机酸可以与矿物结合或与螯合物结合，以进一步改善溶解度，吸收和/或生物利用度。 包括一种或多种混合氨基酸/矿物化合物的组合物可以包括在用于矿物可以治疗和/或预防病症或症状的适应症的治疗方案中。
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公开(公告)号：US20080085877A1
公开(公告)日：2008-04-10
申请号：US11502066
申请日：2006-08-10
申请人： Jonathan Bortz
发明人： Jonathan Bortz
CPC分类号： A61K31/56
摘要： A method for preventing or treating a catamenial migrainous disorder in a female subject comprises administering to a vulvovaginal surface of the subject a pharmaceutical composition that is bioadhesive thereto and comprises at least one estrogenic compound in an amount of about 50 μg to about 1000 μg estradiol equivalent per unit dose of the composition. A related method comprises administering to a vulvovaginal surface of the subject a pharmaceutical composition comprising at least one estrogenic compound, wherein upon administration of the composition to the vulvovaginal surface, a decline in serum estradiol concentration during a luteal phase of a menstrual cycle is moderated.
摘要翻译： 用于预防或治疗女性受试者的月经偏头痛障碍的方法包括对患者的外阴阴道表面施用生物粘附于其上的药物组合物，并且包含至少一种雌激素化合物，其量为约50至约1000杯雌二醇当量 每单位剂量的组合物。 相关方法包括向受试者的外阴阴道表面施用包含至少一种雌激素化合物的药物组合物，其中当将组合物施用于外阴阴道表面时，月经周期的黄体期期间血清雌二醇浓度的下降得到缓和。
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公开(公告)号：US20070154498A1
公开(公告)日：2007-07-05
申请号：US11635743
申请日：2006-12-06
申请人： Jonathan Bortz , R. Levinson
发明人： Jonathan Bortz , R. Levinson
IPC分类号： A61K38/18 , A61K38/43 , A61K31/714 , A61K31/59 , A61K31/525 , A61K31/51 , A61K31/401 , A61K31/22 , A61K31/366 , A61K38/29
CPC分类号： A61K38/1816 , A61K9/0019 , A61K9/107 , A61K31/22 , A61K31/366 , A61K31/401 , A61K31/51 , A61K31/525 , A61K31/59 , A61K31/714 , A61K33/06 , A61K33/30 , A61K35/60 , A61K38/29 , A61K2300/00
摘要： A method for preventing stenosis and thrombosis of an AV graft is disclosed. An essential fatty acid emulsion is administered to the patient through the AV graft, preferably during dialysis, whereby the anti-inflammatory properties of the essential fatty acid emulsion prevent complications typical of AV grafts.
摘要翻译： 公开了防止AV移植物的狭窄和血栓形成的方法。 优选在透析期间通过AV移植物向患者施用必需脂肪酸乳剂，由此必需脂肪酸乳剂的抗炎特性防止AV移植物典型的并发症。
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公开(公告)号：US20070036848A1
公开(公告)日：2007-02-15
申请号：US11502253
申请日：2006-08-10
申请人： Jonathan Bortz , Thomas Riley
发明人： Jonathan Bortz , Thomas Riley
CPC分类号： A61K9/0014 , A61K9/0034 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/567 , A61K47/14 , A61K47/24 , A61K47/26 , A61K47/44
摘要： A pharmaceutical composition comprises at least one estrogenic compound, the composition being adapted for application in a unit dose amount to a vulvovaginal surface and having at least one nonlipoidal internal phase and at least one lipoidal external phase that is bioadhesive to the vulvovaginal surface, wherein the at least one estrogenic compound is present in an amount of about 5 to about 1000 μg estradiol equivalent per unit dose of the composition, and upon application of the composition to the vulvovaginal surface the at least one estrogenic compound is released over a period of about 3 hours to about 30 days. The composition is useful for vulvovaginal administration to treat atrophic vaginitis or a disorder associated therewith, for example in a menopausal or postmenopausal woman. A method for treating a hypoestrogenism-related condition of the urogenital system of a female patient comprises intravaginal administration of at least one estrogenic compound according to a treatment regimen wherein a series of compositions releasing a progressively increasing daily amount of the at least one estrogenic compound is administered over a period of at least about 1 month.
摘要翻译： 药物组合物包含至少一种雌激素化合物，所述组合物适于以单位剂量施用于外阴阴道表面并且具有至少一个非脂性内相和至少一个与外阴阴道表面生物粘附的脂质外相，其中， 至少一种雌激素化合物以每单位剂量组合物约5至约1000兆克雌二醇当量的量存在，并且当将组合物施用于外阴阴道表面时，至少一种雌激素化合物在约3周期内释放 小时至约30天。 该组合物可用于外阴阴道给药以治疗萎缩性阴道炎或与其相关的病症，例如在绝经或绝经后的女性中。 用于治疗女性患者的泌尿生殖系统的与雌激素相关症状的方法包括根据治疗方案的阴道内施用至少一种雌激素化合物，其中释放逐渐增加的每日量的至少一种雌激素化合物的一系列组合物是 在至少约1个月的时间内进行管理。
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