ANTIBODY FC VARIANTS FOR INCREASED BLOOD HALF-LIFE

    公开(公告)号:US20230061390A1

    公开(公告)日:2023-03-02

    申请号:US17881819

    申请日:2022-08-05

    Abstract: The present invention relates to a polypeptide including an Fc variant produced by substituting a portion of the amino acid sequence of the Fc domain of a human antibody with a different amino acid sequence. The present invention also relates to an antibody including the polypeptide. The Fc variant can find application in a wide range of antibodies and Fc-fusion constructs. In one aspect, the antibody or Fc fusion construct of the present invention is a therapeutic, diagnostic or laboratory reagent, preferably a therapeutic reagent. The Fc variant is suitable for use in the treatment of cancer because its in vivo half-life can be maximized by optimization of the portion of the amino acid sequence. The antibody or Fc fusion construct of the present invention is used to kill target cells that bear a target antigen, for example cancer cells. Alternatively, the antibody or Fc fusion construct of the present invention is used to block, antagonize or agonize a target antigen. For example, the antibody or Fc fusion construct of the present invention may be used to antagonize a cytokine or a cytokine receptor.

    ARRAY ANTENNA WITH SHORTING PIN
    13.
    发明申请

    公开(公告)号:US20220384957A1

    公开(公告)日:2022-12-01

    申请号:US17386903

    申请日:2021-07-28

    Abstract: The disclosure relates to an array antenna, and specifically, relates to an array antenna which improves performance by using a shorting pin. The array antenna includes a first antenna, a second antenna, the first antenna and the second antenna sharing a ground, and a substrate disposed on an upper portion of the ground, and the second antenna is disposed in contact with an upper portion of the substrate, the first antenna is disposed by penetrating through centers of the substrate and the second antenna, the array antenna includes a plurality of feeding pins disposed by penetrating through the second antenna, the substrate, and the ground, and the array antenna includes a plurality of shorting pins penetrating through the second antenna, the substrate, and the ground to be symmetric with the plurality of feeding pins.

    APPARATUS AND METHOD FOR CALCULATING RATIO OF NEGLIGENCE BASED ON 3D SIMULATOR

    公开(公告)号:US20220340146A1

    公开(公告)日:2022-10-27

    申请号:US17729592

    申请日:2022-04-26

    Abstract: This application relates to a device and a method for calculating a fault ratio. The method may include by using image frames collected from a camera of a first vehicle, generating a driving route in which the first vehicle travels, and acquiring fault information of a traffic accident involving a second vehicle, the traffic accident being related to the driving route of the first vehicle. The method may also include changing factors related to braking or steering of the first vehicle and the second vehicle, and generating multiple simulation driving scenarios by simulating the driving route on the basis of the changed factors. The method may further include computing a fault ratio of the first vehicle and the second vehicle for each of the multiple simulation driving scenarios by correcting the fault information on the basis of the factors.

    Bio illuminance measuring device for determining circadian action

    公开(公告)号:US11326938B2

    公开(公告)日:2022-05-10

    申请号:US16525190

    申请日:2019-07-29

    Abstract: Disclosed is a bio illuminance measuring apparatus including a circadian lambda filter passing external light along according to a circadian rhythm sensitivity curve, a visual lambda filter passing the external light along according to a visual sensitivity curve, a photo sensing portion sensing and converting the external light, which has passed through the circadian lambda filter, into a circadian wavelength signal and sensing and converting the external light, which has passed through the visual lambda filter, into a visual wavelength signal, and an illuminance calculating portion which calculates a ratio between the circadian wavelength signal and the visual wavelength signal, calculates a circadian action factor by applying the ratio between the circadian wavelength signal and the visual wavelength signal to a circadian action function which varies according to the visual wavelength signal, and calculates a bio illuminance value of the external light on the basis of the circadian action factor.

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