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公开(公告)号：US20090076502A1
公开(公告)日：2009-03-19
申请号：US12283847
申请日：2008-09-15
Applicant: Larry Azure , Charles Hill , Andrew L. Azure
Inventor： Larry Azure , Charles Hill , Andrew L. Azure
IPC: A61B18/14
CPC classification number: A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2017/00274 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00547 , A61B2018/00577 , A61B2018/1425 , A61B2018/143 , A61B2562/0271 , A61B2576/00
Abstract: Methods and systems for delivering electrical energy and controlled, mild hyperthermia to a prostate tissue of a patient for destruction of cancerous and/or hyperplastic tissue. A method includes positioning a plurality of electrodes in a target tissue region comprising the prostate tissue, and establishing an alternating electrical current flow through a volume of the prostate tissue to induce mild heating and destruction of cancerous cells in the volume.
Abstract translation: 用于向患者的前列腺组织递送电能和受控的轻度热疗的方法和系统用于破坏癌性和/或增生组织。 一种方法包括将多个电极定位在包括前列腺组织的靶组织区域中，以及建立通过一定体积的前列腺组织的交流电流，以引起体积中癌细胞的温和加热和破坏。
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12.发明申请公开(公告)号：US20090076494A1
公开(公告)日：2009-03-19
申请号：US12283940
申请日：2008-09-15
Applicant: Larry Azure
Inventor： Larry Azure
CPC classification number: A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2017/00274 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00547 , A61B2018/00577 , A61B2018/1425 , A61B2018/143 , A61B2562/0271 , A61B2576/00
Abstract: Transurethral systems and methods for delivering electrical energy and controlled, mild heating to a prostate tissue of a patient for destruction of cancerous and/or hyperplastic tissue. A method includes positioning an elongate urethral probe having an expandable member with electrode elements at a target location in the patient's urethra, and inflating or expanding at the target location. Secondary electrodes are positioned within or adjacent to the prostate tissue and spaced from the electrode elements of the expandable member, and an alternating electrical current flow is established between the electrode elements of the expandable member and the one or more secondary electrodes. Current delivery can be selected so as to destroy or ablate cancerous cells of the prostate tissue.
Abstract translation: 用于递送电能的经尿道系统和方法，以及对患者的前列腺组织的受控轻度加热以破坏癌性和/或增生组织的方法。 一种方法包括将具有可扩张构件的细长尿道探针定位在患者尿道中的目标位置处，并且在目标位置处膨胀或扩张。 次级电极位于前列腺组织内或与前列腺组织相邻并且与可扩张构件的电极元件间隔开，并且在可扩张构件的电极元件和一个或多个次级电极之间建立交流电流。 可以选择当前的输送来破坏或消融前列腺组织的癌细胞。
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公开(公告)号：US20080071262A1
公开(公告)日：2008-03-20
申请号：US11855977
申请日：2007-09-14
Applicant: Larry Azure
Inventor： Larry Azure
IPC: A61B18/12
CPC classification number: A61B18/1477 , A61B18/1492 , A61B2018/00577 , A61B2018/1407 , A61B2018/1425 , A61B2018/143 , A61B2018/1475 , A61N1/06
Abstract: The present invention provides devices and systems, as well as methods, of electric field delivery and ablation (e.g., non-thermal ablation) of target tissues, including cancerous cells and solid tumors. A method of the present invention can include applying an alternating current to a target tissue and removing ablated or liquefied tissue from the target tissue region.
Abstract translation: 本发明提供了包括癌细胞和实体瘤的靶组织的电场传递和消融（例如非热消融）的装置和系统以及方法。 本发明的方法可以包括向目标组织施加交流电流并从目标组织区域去除消融或液化的组织。
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公开(公告)号：US09526911B1
公开(公告)日：2016-12-27
申请号：US13095804
申请日：2011-04-27
Applicant: Larry Azure , Charles E. Hill , Andrew L. Azure , Rafael Ponce , Lawrence L. Kunz
Inventor： Larry Azure , Charles E. Hill , Andrew L. Azure , Rafael Ponce , Lawrence L. Kunz
CPC classification number: A61B18/14 , A61B18/1206 , A61B18/1477 , A61B18/18 , A61B2017/00867 , A61B2018/0016 , A61B2018/00577 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1475 , A61N1/403 , A61N5/025 , A61N5/0625
Abstract: Systems and methods for delivering electric fields to a target tissue of a patient for destruction of cancerous cells so as to elicit or induce a specific anti-cancerous cell immune response in the patient.
Abstract translation: 将电场递送到患者的靶组织以破坏癌细胞以便引发或诱导患者中特异性抗癌细胞免疫应答的系统和方法。
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公开(公告)号：US09308039B2
公开(公告)日：2016-04-12
申请号：US13344373
申请日：2012-01-05
Applicant: Larry Azure
Inventor： Larry Azure
CPC classification number: A61B18/1477 , A61B18/1492 , A61B2018/00577 , A61B2018/1407 , A61B2018/1425 , A61B2018/143 , A61B2018/1475 , A61N1/06
Abstract: The present invention provides systems, devices and related methods for applying electric fields for cancerous cell destruction and tissue ablation. A method can include advancing an ablation probe into a patient; deploying a guide from the delivery member along a guide tissue penetration path, deploying an electrode from the guide along an electrode tissue penetration path, and establishing current flow within the target tissue.
Abstract translation: 本发明提供了用于对癌细胞破坏和组织消融施加电场的系统，装置和相关方法。 一种方法可以包括将消融探针推进到患者体内; 沿着引导组织穿透路径从所述递送构件展开引导件，沿着电极组织穿透路径从所述引导件展开电极，以及在所述靶组织内建立电流。
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Patent Agency Ranking
公开(公告)号：US08562602B2
公开(公告)日：2013-10-22
申请号：US12210942
申请日：2008-09-15
Applicant: Larry Azure
Inventor： Larry Azure
IPC: A61B18/14
CPC classification number: A61B18/14 , A61B18/1477 , A61B18/18 , A61B2017/00867 , A61B2018/0016 , A61B2018/1407 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1475 , A61N1/05 , C08L2201/12
Abstract: Electric field delivery and ablation of target tissue regions, including cancerous cells and solid tumors. Methods and systems include delivering an electric field to a target tissue, and may include positioning a first electrode or plurality to at least partially define a first treatment volume in the target tissue; positioning a second electrode or plurality to at least partially define a second treatment volume, the first volume is disposed in the second volume; and establishing a first current flow extending through the first volume and a second current flow extending through the second volume.
Abstract translation: 目标组织区域的电场传递和消融，包括癌细胞和实体瘤。 方法和系统包括向目标组织递送电场，并且可以包括定位第一电极或多个以至少部分地限定目标组织中的第一治疗体积; 定位第二电极或多个以至少部分地限定第二处理体积，第一体积设置在第二体积中; 以及建立延伸穿过第一容积的第一电流和延伸穿过第二容积的第二电流。
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公开(公告)号：US20090076500A1
公开(公告)日：2009-03-19
申请号：US12210956
申请日：2008-09-15
Applicant: Larry Azure
Inventor： Larry Azure
IPC: A61B18/14
CPC classification number: A61B18/1477 , A61B18/14 , A61B2018/00267 , A61B2018/00577 , A61B2018/1407 , A61B2018/143 , A61B2018/1475
Abstract: The present invention provides devices and systems, as well as methods, of electric field delivery and non-thermal or mild hyperthermia, and preferential or selective ablation of cancerous cells of target tissue regions. A method can include, for example, advancing a probe comprising a plurality of electrodes to a target tissue region comprising cancerous cells, and deploying the plurality of electrodes from a distal portion of a probe, and applying an alternating current so as to provide one or more electric fields extending through the volume and selectively or preferentially destroy cancerous cells within the volume.
Abstract translation: 本发明提供了电场传递和非热或轻度高热的装置和系统以及靶组织区癌细胞优先或选择性消融的装置和系统。 一种方法可以包括例如将包括多个电极的探针推进到包含癌细胞的靶组织区域，以及从探针的远端部分展开多个电极，以及施加交流电流以提供一个或多个 更多的电场延伸通过体积并选择性地或优先地破坏体积内的癌细胞。
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公开(公告)号：US20090076496A1
公开(公告)日：2009-03-19
申请号：US12211101
申请日：2008-09-15
Applicant: Larry Azure
Inventor： Larry Azure
IPC: A61B18/12
CPC classification number: A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2017/00274 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00547 , A61B2018/00577 , A61B2018/1425 , A61B2018/143 , A61B2562/0271 , A61B2576/00
Abstract: Methods and systems for delivering electrical energy and controlled, mild hyperthermia to a prostate tissue of a patient for destruction of cancerous and/or hyperplastic tissue. A method includes positioning a plurality of electrodes in a target tissue region comprising the prostate tissue, and establishing an alternating electrical current flow through a volume of the prostate tissue to induce mild heating and destruction of cancerous cells in the volume.
Abstract translation: 用于向患者的前列腺组织递送电能和受控的轻度热疗的方法和系统用于破坏癌性和/或增生组织。 一种方法包括将多个电极定位在包括前列腺组织的靶组织区域中，以及建立通过一定体积的前列腺组织的交流电流，以引起体积中癌细胞的温和加热和破坏。
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公开(公告)号：US20080071265A1
公开(公告)日：2008-03-20
申请号：US11855956
申请日：2007-09-14
Applicant: Larry Azure
Inventor： Larry Azure
IPC: A61B18/12
CPC classification number: A61B18/1477 , A61B18/1492 , A61B2018/00577 , A61B2018/1407 , A61B2018/1425 , A61B2018/143 , A61B2018/1475 , A61N1/06
Abstract: The present invention provides devices and systems, as well as methods, of electric field delivery and non-thermal or selective ablation of target tissue regions, including selective ablation of cancerous cells and solid tumors. A method of the present invention includes delivering an electric field to a tissue, including positioning an electrode within a target tissue region comprising cancerous cells, and applying an alternating electrical current to the target tissue so as to non-thermally ablate cancerous cells of the target tissue region around the electrodes.
Abstract translation: 本发明提供了靶区组织的电场传递和非热或选择性消融的装置和系统以及方法，包括癌细胞和实体瘤的选择性消融。 本发明的方法包括将电场递送到组织，包括将电极定位在包含癌细胞的靶组织区域内，以及向目标组织施加交流电流，以便不热烧蚀靶标的癌细胞 电极周围的组织区域。
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公开(公告)号：US08915911B2
公开(公告)日：2014-12-23
申请号：US12759611
申请日：2010-04-13
Applicant: Larry Azure
Inventor： Larry Azure
CPC classification number: A61B18/1477 , A61B18/1492 , A61B2018/00577 , A61B2018/1407 , A61B2018/1425 , A61B2018/143 , A61B2018/1475 , A61N1/06
Abstract: The present invention provides devices and systems, as well as methods, of electric field delivery and non-thermal or selective ablation of target tissue regions, including selective ablation of cancerous cells and solid tumors. A method of the present invention includes delivering an electric field to a tissue, including positioning an electrode within a target tissue region comprising cancerous cells, and applying an alternating electrical current to the target tissue so as to non-thermally ablate cancerous cells of the target tissue region around the electrodes.
Abstract translation: 本发明提供了靶区组织的电场传递和非热或选择性消融的装置和系统以及方法，包括癌细胞和实体瘤的选择性消融。 本发明的方法包括将电场传送到组织，包括将电极定位在包含癌细胞的靶组织区域内，并向目标组织施加交流电流，以便不热烧蚀靶标的癌细胞 电极周围的组织区域。
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