公开(公告)号：US07869862B2

公开(公告)日：2011-01-11

申请号：US10687522

申请日：2003-10-15

Applicant: Edward J. Seppi ,  Larry Partain ,  Michael Green ,  Gary Virshup

Inventor： Edward J. Seppi ,  Larry Partain ,  Michael Green ,  Gary Virshup

IPC: A61B6/00

CPC classification number: A61B6/405 ,  A61B5/7289 ,  A61B5/7292 ,  A61B6/032 ,  A61B6/0435 ,  A61B6/4035 ,  A61B6/4042 ,  A61B6/4241 ,  A61B6/4441 ,  A61B6/4488 ,  A61B6/466 ,  A61B6/481 ,  A61B6/482 ,  A61B6/502 ,  A61B6/504 ,  A61B6/5288 ,  A61B6/541 ,  G01N23/046 ,  G01N2223/419 ,  G01N2223/612 ,  H01J2235/081

Abstract: A method of generating images of a portion of a body includes introducing a contrast agent into the body, generating a first set of image data using radiation at a first energy level after the contrast agent is introduced into the body, generating a second set of image data using radiation at a second energy level after the contrast agent is introduced into the body, and creating a volumetric composite image using the first and the second sets of image data.

Abstract translation: 产生身体部分的图像的方法包括将造影剂引入体内，在将造影剂引入体内之后，以第一能量级别的辐射产生第一组图像数据，产生第二组图像 在将造影剂引入身体之后，使用在第二能量级别的辐射的数据，以及使用第一和第二组图像数据创建体积合成图像。

公开(公告)号：US20080237481A1

公开(公告)日：2008-10-02

申请号：US11731170

申请日：2007-03-29

Applicant: George Zentai ,  Larry Partain ,  William Wei-Yu Yao ,  Richard Weisfield

Inventor： George Zentai ,  Larry Partain ,  William Wei-Yu Yao ,  Richard Weisfield

IPC: G01T1/24 ,  H01L27/146

CPC classification number: H01L27/14676 ,  G01T1/244 ,  H01L27/14618 ,  H01L27/1462 ,  H01L2924/0002 ,  H01L2924/00

Abstract: Improved corrosion resistance for direct X-ray imaging detectors is obtained by providing a pixelated, electrically conductive barrier layer between the X-ray sensitive material and the pixel electrodes. Each barrier layer can cover part or all of its corresponding pixel electrode. In cases where pixel electrodes makes contact to underlying circuitry through vertical vias, it is preferred for the barrier layers to cover the via sections of the pixel electrodes. The barrier layers for each pixel electrode can be spaced apart from each other, or they can all be included within a continuous film on top of the pixel electrodes. Such a continuous film can be pixelated by spatially modulating its properties (e.g., thickness, doping) to significantly reduce lateral conductivity from pixel to pixel.

Abstract translation: 通过在X射线敏感材料和像素电极之间提供像素化的导电阻挡层，可以获得直接X射线成像检测器的耐腐蚀性。 每个阻挡层可以覆盖其对应的像素电极的部分或全部。 在像素电极通过垂直通孔与底层电路接触的情况下，优选阻挡层覆盖像素电极的通孔部分。 每个像素电极的阻挡层可以彼此间隔开，或者它们都可以包括在像素电极顶部的连续膜内。 这样的连续膜可以通过空间调节其性质（例如，厚度，掺杂）而被像素化，以显着降低从像素到像素的横向电导率。

公开(公告)号：US20070269000A1

公开(公告)日：2007-11-22

申请号：US11437076

申请日：2006-05-18

Applicant: Larry Partain ,  Stavros Prionas ,  Edward Seppi ,  Robert Sutherland ,  David Humber ,  Hassan Mostafavi ,  Felix Fernando ,  John Boone

Inventor： Larry Partain ,  Stavros Prionas ,  Edward Seppi ,  Robert Sutherland ,  David Humber ,  Hassan Mostafavi ,  Felix Fernando ,  John Boone

IPC: A61B6/04

CPC classification number: A61B6/4241 ,  A61B6/032 ,  A61B6/4085 ,  A61B6/482 ,  A61B6/502 ,  A61B6/507

Abstract: A method of imaging a patient's uncompressed region of interest using X-ray cone beam computed tomography or cone beam digital tomography comprises the step of introducing an effective amount of a contrast agent to the uncompressed region of interest. A system for imaging a patient's uncompressed region of interest using cone beam computed tomography (CBCT) or cone beam digital tomography (CBDT) comprises an X-ray source transmitting an X-ray to the uncompressed region of interest, an image acquisition system acquiring a plurality of two-dimensional projection images data for a CBCT or CBDT data set with at least one of the projection images acquired in 35 milliseconds or less, and a processor generating a three-dimensional computed tomography image data set resolving voxels with dimensions of 0.4 mm or less in at least two orthogonal directions.

Abstract translation: 使用X射线锥束计算机断层摄影或锥束数字断层摄影术对患者未压缩感兴趣区域成像的方法包括将有效量的造影剂引入未压缩感兴趣区域的步骤。 使用锥形束计算机断层摄影（CBCT）或锥束数字断层摄影（CBDT）对患者未压缩感兴趣区域成像的系统包括将X射线发射到感兴趣的未压缩区域的X射线源，获取 多个用于CBCT或CBDT数据集的二维投影图像数据，其具有在35毫秒或更短时间内获取的至少一个投影图像，以及处理器，其生成尺寸为0.4mm的三维计算机断层摄影图像数据集 或至少两个正交方向。

公开(公告)号：US20060262898A1

公开(公告)日：2006-11-23

申请号：US11134695

申请日：2005-05-20

Applicant: Larry Partain ,  David Humber

Inventor： Larry Partain ,  David Humber

IPC: A61B6/04

CPC classification number: A61B6/482 ,  A61B6/032 ,  A61B6/0414 ,  A61B6/107 ,  A61B6/405 ,  A61B6/4441 ,  A61B6/466 ,  A61B6/502 ,  A61B6/541 ,  A61N5/10 ,  A61N5/1081 ,  A61N2005/1097

Abstract: The present invention provides a system 10 for irradiating a breast 20 of a patient 22. The system 10 comprises a gantry 12 rotatable about a horizontal axis 14 and comprising a radiation source 16 for generating a radiation beam 18 and a detector 24 spaced from the radiation source 16, and a barrier 26 disposed between the patient 22 and the gantry 12. The barrier 26 is provided with an opening 30 adapted to allow a breast 20 passing therethrough to be exposed to the radiation beam 18. In some embodiments, the barrier 26 is provided with an opening 30 adapted to allow both the breast 20 and the tissue leading from the breast to axilla and the muscle tissue of the adjacent chest wall passing therethrough to be exposed to the radiation beam 18.

Abstract translation: 本发明提供一种用于照射患者22的乳房20的系统10。 系统10包括可围绕水平轴线14旋转并且包括用于产生辐射束18的辐射源16和与辐射源16间隔开的检测器24的台架12以及设置在患者22和台架12之间的阻挡层26。 屏障26设置有适于允许穿过其中的乳房20暴露于辐射束18的开口30。 在一些实施例中，屏障26设置有开口30，开口30适于允许乳房20和从乳房到达腋窝的组织和穿过其中的相邻胸壁的肌肉组织暴露于辐射束18。

公开(公告)号：US20050082491A1

公开(公告)日：2005-04-21

申请号：US10687550

申请日：2003-10-15

Applicant: Edward Seppi ,  Larry Partain ,  George Zentai

Inventor： Edward Seppi ,  Larry Partain ,  George Zentai

IPC: G01T1/20 ,  G01T1/24 ,  G01T1/36 ,  H01L27/146

CPC classification number: G01T1/362 ,  A61B5/7289 ,  A61B5/7292 ,  A61B6/032 ,  A61B6/4035 ,  A61B6/405 ,  A61B6/4233 ,  A61B6/4241 ,  A61B6/4441 ,  A61B6/481 ,  A61B6/482 ,  A61B6/502 ,  A61B6/5288 ,  A61B6/541 ,  G01T1/2018 ,  H01L27/14667 ,  H01L27/14676

Abstract: A radiation projection detector includes a conversion layer configured to generate light photons in response to a radiation, the conversion layer having a plurality of first conversion elements and a plurality of second conversion elements, and a photo detector array aligned with the conversion panel, wherein each of the first conversion elements has a first radiation conversion characteristic, and each of the second conversion elements has a second radiation conversion characteristic. A radiation projection detector includes a photoconductor layer configured to generate charges in response to radiation, the photoconductor layer having a plurality of first photoconductor elements and a plurality of second photoconductor elements, and a detector array aligned with the photoconductor layer, wherein each of the first photoconductor elements has a first charge generating characteristic, and each of the second photoconductor elements has a second charge generating characteristic.

Abstract translation: 辐射投影检测器包括被配置为响应于辐射而产生光子的转换层，所述转换层具有多个第一转换元件和多个第二转换元件以及与转换面板对准的光电检测器阵列，其中每个 的第一转换元件具有第一辐射转换特性，并且每个第二转换元件具有第二辐射转换特性。 辐射投影检测器包括被配置为响应于辐射产生电荷的光电导体层，所述光电导体层具有多个第一光电导体元件和多个第二光电导体元件，以及与所述光电导体层对准的检测器阵列，其中所述第一 光电导体元件具有第一电荷产生特性，并且每个第二感光体元件具有第二电荷产生特性。

公开(公告)号：US10380736B1

公开(公告)日：2019-08-13

申请号：US15290951

申请日：2016-10-11

Applicant: Larry Partain ,  George Zentai ,  Stavros Prionas ,  Raisa Pavlyuchkova

Inventor： Larry Partain ,  George Zentai ,  Stavros Prionas ,  Raisa Pavlyuchkova

IPC: G06K9/00 ,  G06T7/00 ,  G06T17/20

Abstract: Methods of obtaining a suspect nodules' sizes and/or growth rate are provided. In one embodiment, the method begins with at a first time: (i) obtaining a first three dimensional (3D) data set cube of voxels of a patient's anatomy including nodules; (ii) creating a second 3D data set cube of the same size as the first where all voxel values are set to zero; (iii) creating multiple Maximum-Intensity-Projection (MIP) images from the first 3D data set cube taken at different angles; (iv) replacing those voxels in the second 3D data set cube with corresponding voxels from the first 3D data set cube that provide non-zero values in the multiple MIP images; and (v) converting data in the second 3D data set cube into closed surface volumes, cross sectional areas or linear dimensions using image segmentation. Data from a second time can be used to determine growth rate.

公开(公告)号：US08232531B2

公开(公告)日：2012-07-31

申请号：US11731170

申请日：2007-03-29

Applicant: George Zentai ,  Larry Partain ,  William Wei-Yu Yao ,  Richard Weisfield

Inventor： George Zentai ,  Larry Partain ,  William Wei-Yu Yao ,  Richard Weisfield

IPC: H01L25/00

CPC classification number: H01L27/14676 ,  G01T1/244 ,  H01L27/14618 ,  H01L27/1462 ,  H01L2924/0002 ,  H01L2924/00

Abstract: Improved corrosion resistance for direct X-ray imaging detectors is obtained by providing a pixelated, electrically conductive barrier layer between the X-ray sensitive material and the pixel electrodes. Each barrier layer can cover part or all of its corresponding pixel electrode. In cases where pixel electrodes makes contact to underlying circuitry through vertical vias, it is preferred for the barrier layers to cover the via sections of the pixel electrodes. The barrier layers for each pixel electrode can be spaced apart from each other, or they can all be included within a continuous film on top of the pixel electrodes. Such a continuous film can be pixelated by spatially modulating its properties (e.g., thickness, doping) to significantly reduce lateral conductivity from pixel to pixel.

Abstract translation: 通过在X射线敏感材料和像素电极之间提供像素化的导电阻挡层，可以获得直接X射线成像检测器的耐腐蚀性。 每个阻挡层可以覆盖其对应的像素电极的部分或全部。 在像素电极通过垂直通孔与底层电路接触的情况下，优选阻挡层覆盖像素电极的通孔部分。 每个像素电极的阻挡层可以彼此间隔开，或者它们都可以包括在像素电极顶部的连续膜内。 这样的连续膜可以通过空间调节其性质（例如，厚度，掺杂）而被像素化，以显着降低从像素到像素的横向电导率。

公开(公告)号：US08036435B2

公开(公告)日：2011-10-11

申请号：US11864856

申请日：2007-09-28

Applicant: Larry Partain ,  Stavros Prionas ,  John Boone

Inventor： Larry Partain ,  Stavros Prionas ,  John Boone

IPC: G06K9/00

CPC classification number: G06T7/0012 ,  G06T7/11 ,  G06T2207/30096

Abstract: A method of analyzing a volumetric data set obtained by an imaging system from an object is provided includes defining a first region of interest comprising a population of voxels of a first tissue part of the object to obtain a first distribution of radiation attenuation coefficient values, defining a second region of interest comprising a sample of voxels of a second tissue part of the object to obtain a second distribution of radiation attenuation coefficient values, and distinguishing the second tissue from the first tissue using the properties of the first and second distributions of radiation attenuation coefficients.

Abstract translation: 提供了一种从对象中分析由成像系统获得的体数据集的方法，包括定义第一感兴趣区域，其包括物体的第一组织部分的体素群，以获得辐射衰减系数值的第一分布，定义 第二感兴趣区域包括物体的第二组织部分的体素样本以获得辐射衰减系数值的第二分布，以及使用辐射衰减的第一和第二分布的特性来区分第二组织和第一组织 系数。

公开(公告)号：US08009794B2

公开(公告)日：2011-08-30

申请号：US12360795

申请日：2009-01-27

Applicant: Larry Partain

Inventor： Larry Partain

IPC: A61B6/03 ,  H05G1/64 ,  G21K1/04

CPC classification number: A61B6/032 ,  A61B6/035 ,  A61B6/06 ,  A61B6/4085 ,  G21K1/043 ,  G21K1/046

Abstract: Disclosed are methods, systems, and computer-product programs for increasing accuracy in cone-beam computed tomography (CBCT) by obscuring portions of the radiation source so that the radiation only passes through the specific areas of the patient related to the regions-of-interest to the doctor. The obscuring action causes less radiation scattering to occur in the patient's body, thereby reducing a major source of error in the image accuracy caused by scattered radiation. Scattered radiation received by detector pixels that are obscured by direct-line of sight radiation may be used to estimate the scattered radiation in the un-obscured portion, which can be used to further increase the accuracy of the image.

Abstract translation: 公开了用于通过遮蔽辐射源的部分来增加锥束计算机断层摄影（CBCT）的精度的方法，系统和计算机产品程序，使得辐射仅通过患者的与区域相关的特定区域， 对医生的兴趣。 模糊的动作导致在患者体内发生更少的辐射散射，从而减少由散射辐射引起的图像精度的主要误差源。 由直接视线辐射遮蔽的检测器像素接收的散射辐射可以用于估计未遮蔽部分中的散射辐射，其可以用于进一步增加图像的准确度。

公开(公告)号：US20110133094A1

公开(公告)日：2011-06-09

申请号：US13026151

申请日：2011-02-11

Applicant: Edward J. SEPPI ,  Larry PARTAIN ,  George ZENTAI

Inventor： Edward J. SEPPI ,  Larry PARTAIN ,  George ZENTAI

IPC: G01T1/20 ,  G01T1/16

CPC classification number: G01T1/362 ,  A61B5/7289 ,  A61B5/7292 ,  A61B6/032 ,  A61B6/4035 ,  A61B6/405 ,  A61B6/4233 ,  A61B6/4241 ,  A61B6/4441 ,  A61B6/481 ,  A61B6/482 ,  A61B6/502 ,  A61B6/5288 ,  A61B6/541 ,  G01T1/2018 ,  H01L27/14667 ,  H01L27/14676

Abstract: A radiation projection detector includes a conversion layer configured to generate light photons in response to a radiation, the conversion layer having a plurality of first conversion elements and a plurality of second conversion elements, and a photo detector array aligned with the conversion panel, wherein each of the first conversion elements has a first radiation conversion characteristic, and each of the second conversion elements has a second radiation conversion characteristic. A radiation projection detector includes a photoconductor layer configured to generate charges in response to radiation, the photoconductor layer having a plurality of first photoconductor elements and a plurality of second photoconductor elements, and a detector array aligned with the photoconductor layer, wherein each of the first photoconductor elements has a first charge generating characteristic, and each of the second photoconductor elements has a second charge generating characteristic.

Abstract translation: 辐射投影检测器包括被配置为响应于辐射而产生光子的转换层，所述转换层具有多个第一转换元件和多个第二转换元件以及与转换面板对准的光电检测器阵列，其中每个 的第一转换元件具有第一辐射转换特性，并且每个第二转换元件具有第二辐射转换特性。 辐射投影检测器包括被配置为响应于辐射产生电荷的光电导体层，所述光电导体层具有多个第一光电导体元件和多个第二光电导体元件，以及与所述光电导体层对准的检测器阵列，其中所述第一 光电导体元件具有第一电荷产生特性，并且每个第二感光体元件具有第二电荷产生特性。