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公开(公告)号:US20140058129A1
公开(公告)日:2014-02-27
申请号:US13973629
申请日:2013-08-22
IPC分类号: C07C227/02 , C07C227/22
CPC分类号: C07C227/02 , C07C227/22 , C07C229/42
摘要: Compounds of formula (I) pharmaceutically acceptable salts thereof; and pharmaceutically acceptable esters thereof; which are useful for the treatment of COX-2 dependent disorders.
摘要翻译: 式(I)的化合物及其药学上可接受的盐; 及其药学上可接受的酯; 其可用于治疗COX-2依赖性疾病。
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公开(公告)号:US08586782B2
公开(公告)日:2013-11-19
申请号:US13611365
申请日:2012-09-12
IPC分类号: C07C205/00 , C07C207/00
CPC分类号: C07C227/02 , C07C227/22 , C07C229/42
摘要: Compounds of formula (I) pharmaceutically acceptable salts thereof; and pharmaceutically acceptable esters thereof; which are useful for the treatment of COX-2 dependent disorders.
摘要翻译: 式(I)的化合物及其药学上可接受的盐; 及其药学上可接受的酯; 其可用于治疗COX-2依赖性疾病。
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公开(公告)号:US08575160B2
公开(公告)日:2013-11-05
申请号:US13511581
申请日:2010-11-29
申请人: Robert Sun , Lauren G. Monovich , Sylvie Chamoin , John Westbrook
发明人: Robert Sun , Lauren G. Monovich , Sylvie Chamoin , John Westbrook
IPC分类号: C07D487/04 , A61K31/4188 , A61K31/428
CPC分类号: C07D487/04 , C07D471/04
摘要: The present invention provides a compound of formula (I) or pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, R7 and p are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译: 本发明提供式(I)化合物或其药学上可接受的盐,其中变量R1,R2,R3,R4,R5,R7和p在本文中定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号:US20130065893A1
公开(公告)日:2013-03-14
申请号:US13511581
申请日:2010-11-29
申请人: Robert Sun , Lauren G. Monovich , Sylvie Chamoin , John Westbrook
发明人: Robert Sun , Lauren G. Monovich , Sylvie Chamoin , John Westbrook
IPC分类号: C07D487/04 , A61K31/4188 , A61K31/428 , A61K31/437 , A61K31/5377 , A61K31/4439 , A61K31/4725 , A61K31/4709 , A61P9/12 , A61P9/10 , A61P3/04 , A61P9/00 , A61P9/06 , A61P9/04 , A61P1/16 , C07D471/04
CPC分类号: C07D487/04 , C07D471/04
摘要: The present invention provides a compound of formula (I) or pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, R7 and p are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译: 本发明提供式(I)化合物或其药学上可接受的盐,其中变量R1,R2,R3,R4,R5,R7和p在本文中定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号:US08362294B2
公开(公告)日:2013-01-29
申请号:US12305531
申请日:2007-06-25
IPC分类号: C07C205/00 , C07C207/00 , A61K31/195
CPC分类号: C07C227/02 , C07C227/22 , C07C229/42
摘要: Compounds of formula (I) pharmaceutically acceptable salts thereof, and pharmaceutically acceptable esters thereof; which are useful for the treatment of COX-2 dependent disorders.
摘要翻译: 式(I)的化合物及其药学上可接受的盐及其药学上可接受的酯; 其可用于治疗COX-2依赖性疾病。
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公开(公告)号:US20130012585A1
公开(公告)日:2013-01-10
申请号:US13611365
申请日:2012-09-12
IPC分类号: C07C229/42 , C07C227/22 , C07C227/02 , A61P35/00 , A61P19/02 , A61P15/00 , A61P25/00 , A61K31/196 , A61P29/00
CPC分类号: C07C227/02 , C07C227/22 , C07C229/42
摘要: Compounds of formula (I) pharmaceutically acceptable salts thereof; and pharmaceutically acceptable esters thereof; which are useful for the treatment of COX-2 dependent disorders.
摘要翻译: 式(I)的化合物及其药学上可接受的盐; 及其药学上可接受的酯; 其可用于治疗COX-2依赖性疾病。
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公开(公告)号:US20120277215A1
公开(公告)日:2012-11-01
申请号:US13540113
申请日:2012-07-02
申请人: Gary Michael Ksander , Erik Meredith , Lauren G. Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
发明人: Gary Michael Ksander , Erik Meredith , Lauren G. Monovich , Julien Papillon , Fariborz Firooznia , Qi-Ying Hu
IPC分类号: C07D487/04 , A61K31/5377 , A61K31/454 , C07D487/20 , C07D471/04 , A61K31/437 , A61K31/55 , A61P9/12 , A61P9/04 , A61P13/12 , A61P9/10 , A61P3/00 , A61P3/04 , A61P9/00 , A61P29/00 , A61P19/10 , A61P35/00 , A61P15/08 , A61K31/4188
CPC分类号: C07D471/04 , A61K31/4188 , A61K31/437 , A61K31/454 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04
摘要: The present invention provides a compound of formula I: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.
摘要翻译: 本发明提供式I化合物:所述化合物是醛固酮合成酶和芳香酶的抑制剂,因此可用于治疗由醛固酮合成酶或芳香酶介导的病症或疾病。 因此,式I化合物可用于治疗低钾血症,高血压,充血性心力衰竭,心房颤动,肾衰竭,特别是慢性肾衰竭,再狭窄,动脉粥样硬化,综合征X,肥胖症,肾病,心肌梗塞后, 冠状动脉心脏病,炎症,胶原蛋白形成增加,纤维化如心脏或心肌纤维化,以及高血压和内皮功能障碍后重塑,男子乳腺发育不良,骨质疏松症,前列腺癌,子宫内膜异位症,子宫肌瘤,功能障碍性子宫出血,子宫内膜增生,多囊卵巢疾病,不育症 ,纤维囊性乳腺疾病,乳腺癌和纤维囊性乳腺病。 最后,本发明还提供药物组合物。
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