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    Method of making 6-aminocaproic acid as active pharmaceutical ingredient
    3.
    发明授权
    Method of making 6-aminocaproic acid as active pharmaceutical ingredient 有权
    制备6-氨基己酸作为活性药物成分的方法

    公开(公告)号：US08809581B2

    公开(公告)日：2014-08-19

    申请号：US13660126

    申请日：2012-10-25

    申请人： Sunny pharmtech Inc.

    发明人： Jien-Heh Tien ,  Chu-yi Pang

    IPC分类号： C07C205/00

    CPC分类号： C07C227/22 ,  C07C227/38

    摘要： The present invention provides a method for making 6-aminocaproic acid as an active pharmaceutical ingredient. The method comprises: performing a hydrolysis procedure to have ε-caprolactam react with acid or base to generate a first reaction mixture, performing a modification procedure to have a solubility regulating agent reacts with 6-aminocaproic acid in the first reaction mixture to form a second reaction mixture including an aminocaproic acid intermediate, performing a separation procedure to have the intermediate separated from the second reaction mixture and performing a hydrogenation procedure to have the aminocaproic acid intermediate hydrogenated to form a 6-aminocaproic acid product.

    摘要翻译： 本发明提供了制备6-氨基己酸作为活性药物成分的方法。 该方法包括：进行水解步骤以使ε-己内酰胺与酸或碱反应以产生第一反应混合物，进行改性步骤以使溶解调节剂与第一反应混合物中的6-氨基己酸反应形成 第二反应混合物，包括氨基己酸中间体，进行分离步骤以使中间体与第二反应混合物分离，并进行氢化方法使氨基己酸中间体氢化形成6-氨基己酸产物。

    PROCESS FOR PRODUCTION OF BICYCLO[2.2.2]OCTYLAMINE DERIVATIVE
    7.
    发明申请
    PROCESS FOR PRODUCTION OF BICYCLO[2.2.2]OCTYLAMINE DERIVATIVE 失效
    双酚A [2.2.2]衍生物的生产方法

    公开(公告)号：US20110137070A1

    公开(公告)日：2011-06-09

    申请号：US13057879

    申请日：2009-08-07

    申请人： Tomohiro Akeboshi ,  Yusuke Iriyama ,  Hirotaka Kawanami

    发明人： Tomohiro Akeboshi ,  Yusuke Iriyama ,  Hirotaka Kawanami

    IPC分类号： C07C67/343 ,  C07C67/30 ,  C07C251/20 ,  C07C69/757 ,  C07C69/753

    CPC分类号： C07C229/50 ,  C07C227/16 ,  C07C227/22 ,  C07C249/02 ,  C07C251/20 ,  C07C303/28 ,  C07C309/66 ,  C07C2602/44

    摘要： The present invention herein provides a process for production of a bicyclo[2.2.2]octylamine derivative which may be used as an intermediate for preparation of medical and pharmaceutical products. The process is quite efficient and can produce the derivative in a large-scale while using mild reaction conditions.The process for producing a bicyclo[2.2.2]octylamine derivative comprises the steps of subjecting, to ring-formation, a compound represented by the following general formula (1): [wherein R1 represents an alkyl group having 1 to 6 carbon atoms, which may have a substituent; an arylmethyl group which may have a substituent; or an arylethyl group which may have a substituent], and a compound represented by the following general formula (2): R2—NH2   (2) [wherein R2 represents an alkyl group having 1 to 6 carbon atoms, which may have a substituent; an aralkyl group which may have a substituent; a hydroxyl group; an alkyloxy group having 1 to 6 carbon atoms, which may have a substituent; or an aralkyloxy group which may have a substituent], and then reducing the resulting product.

    摘要翻译： 本发明提供了可用作制备医药产品的中间体的双环[2.2.2]辛胺衍生物的制备方法。 该方法是非常有效的，并且可以在使用温和的反应条件的情况下大量产生衍生物。 制备双环[2.2.2]辛胺衍生物的方法包括以下步骤：使由下列通式（1）表示的化合物进行成环：其中R 1表示具有1至6个碳原子的烷基， 其可以具有取代基; 可以具有取代基的芳基甲基; 或可以具有取代基的芳基乙基）和由以下通式（2）表示的化合物：R2-NH2（2）[其中R2表示可以具有取代基的碳原子数1〜6的烷基] 可以具有取代基的芳烷基; 羟基; 可以具有取代基的碳原子数1〜6的烷氧基; 或可具有取代基的芳烷氧基），然后还原所得产物。