公开(公告)号：US07202056B2

公开(公告)日：2007-04-10

申请号：US10403938

申请日：2003-03-28

申请人： Liana M. Lee ,  John N. Feder ,  Shujian Wu ,  Jian Chen

发明人： Liana M. Lee ,  John N. Feder ,  Shujian Wu ,  Jian Chen

IPC分类号： C12P21/06 ,  C12N15/87 ,  C12N1/20 ,  C12N15/74 ,  C07H21/04

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/70503

摘要： The present invention provides novel polynucleotides encoding BGS-19 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying the novel BGS-19 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码BGS-19多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将新型BGS-19多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07199227B2

公开(公告)日：2007-04-03

申请号：US10172094

申请日：2002-06-14

申请人： Donald G. Jackson ,  Matthew V. Lorenzi ,  Ricardo M. Attar ,  Marco Gottardis ,  Liana M. Lee ,  John N. Feder

发明人： Donald G. Jackson ,  Matthew V. Lorenzi ,  Ricardo M. Attar ,  Marco Gottardis ,  Liana M. Lee ,  John N. Feder

IPC分类号： C07H21/04

CPC分类号： C12N9/16

摘要： The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.

摘要翻译： 本发明涉及新发现的人类组蛋白脱乙酰酶（HDAC），也称为组蛋白脱乙酰酶样多肽。 本发明涵盖了新型HDAC的多核苷酸序列和编码多肽，以及包含这些多核苷酸的载体和包含这些载体的宿主细胞。 本发明还涉及结合所公开的HDAC多肽的抗体以及使用这些抗体的方法。 还涉及筛选调节剂的方法，例如抑制剂或拮抗剂或激动剂。 本发明还涉及使用所公开的HDAC多核苷酸，多肽和抗体以及HDAC调节剂的诊断和治疗应用。 这种应用可以用于与异常细胞生长或增殖，细胞分化和细胞存活相关的疾病和病症，例如肿瘤细胞生长，特别是乳腺癌和前列腺癌或肿瘤。