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公开(公告)号：US5939443A
公开(公告)日：1999-08-17
申请号：US882503
申请日：1997-06-25
申请人： Michael Gregory Bell , Thomas Alan Crowell , Christine Ann Droste , Donald Paul Matthews , John Hampton McDonald, III , Christopher John Rito , Anthony John Shuker , Mark Alan Winter
发明人： Michael Gregory Bell , Thomas Alan Crowell , Christine Ann Droste , Donald Paul Matthews , John Hampton McDonald, III , Christopher John Rito , Anthony John Shuker , Mark Alan Winter
IPC分类号： A61K31/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4184 , A61K31/4192 , A61K31/42 , A61K31/423 , A61K31/433 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/496 , A61K31/50 , A61K31/501 , A61K31/53 , A61K31/535 , A61K31/5355 , A61K31/537 , A61K31/5375 , A61K31/5377 , A61P3/00 , A61P3/10 , A61P43/00 , C07C235/46 , C07C255/54 , C07D209/08 , C07D213/63 , C07D235/06 , C07D235/08 , C07D235/26 , C07D249/18 , C07D257/04 , C07D263/56 , C07D263/58 , C07D285/14 , C07D295/18 , C07D333/34 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D209/08 , A61K31/404 , A61K31/4192 , C07D235/06 , C07D235/26 , C07D249/18 , C07D263/58 , C07D285/14 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective .beta.3 adrenergic receptor agonists useful in the treatment of Type II diabetes and obesity. The invention provides compounds and method of treating type II diabetes, comprising administering to a mammal in need thereof compounds of the Formula II: ##STR1## The variables in Formula II are defined herein.
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公开(公告)号：US5786356A
公开(公告)日：1998-07-28
申请号：US882549
申请日：1997-06-25
申请人： Michael Gregory Bell , Thomas Alan Crowell , Donald Paul Matthews , John Hampton McDonald, III , David Andrew Neel , Anthony John Shuker , Mark Alan Winter
发明人： Michael Gregory Bell , Thomas Alan Crowell , Donald Paul Matthews , John Hampton McDonald, III , David Andrew Neel , Anthony John Shuker , Mark Alan Winter
IPC分类号： A61K31/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4184 , A61K31/4192 , A61K31/42 , A61K31/423 , A61K31/433 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/496 , A61K31/50 , A61K31/501 , A61K31/53 , A61K31/535 , A61K31/5355 , A61K31/537 , A61K31/5375 , A61K31/5377 , A61P3/00 , A61P3/10 , A61P43/00 , C07C235/46 , C07C255/54 , C07D209/08 , C07D213/63 , C07D235/06 , C07D235/08 , C07D235/26 , C07D249/18 , C07D257/04 , C07D263/56 , C07D263/58 , C07D285/14 , C07D295/18 , C07D333/34 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/495
CPC分类号： C07D209/08 , A61K31/404 , A61K31/4192 , C07D235/06 , C07D235/26 , C07D249/18 , C07D263/58 , C07D285/14 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective .beta.3 adrenergic receptor agonists useful in the treatment of Type II diabetes and obesity. The invention provides compounds and method of treating type II diabetes, comprising administering to a mammal in need thereof compounds of the Formulas I and II: ##STR1##
摘要翻译： 本发明在医药领域，特别是治疗II型糖尿病和肥胖症。 更具体地，本发明涉及可用于治疗II型糖尿病和肥胖症的选择性β3肾上腺素能受体激动剂。 本发明提供了治疗II型糖尿病的化合物和方法，包括向有需要的哺乳动物施用式I和II的化合物：（I），（II）
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13.发明授权Benzo[B]indeno[2, 1-D]thiophene compounds, intermediates, compositions, and methods 失效苯并[B]茚并[2,1-D]噻吩化合物，中间体，组合物和方法
公开(公告)号：US6133458A
公开(公告)日：2000-10-17
申请号：US163914
申请日：1998-09-30
IPC分类号： A61K31/38 , A61K31/381 , A61P3/02 , A61P3/06 , A61P19/10 , A61P43/00 , C07D333/78 , C07D409/14 , C07D333/50
CPC分类号： C07D333/78
摘要： The invention provides benzo[b]indenothiophene compounds, intermediates, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, cardiovascular-related pathological conditions including hyperlipidemia and related cardiovascular pathologies, and estrogen-dependent cancer.
摘要翻译： 本发明提供苯并[b]茚噻吩化合物，中间体，制剂和抑制骨丢失或骨吸收的方法，特别是骨质疏松症，心血管相关的病理状况，包括高脂血症和相关心血管病变以及雌激素依赖性癌症。
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