公开(公告)号：US07612211B2

公开(公告)日：2009-11-03

申请号：US11954647

申请日：2007-12-12

Applicant: Wing S. Cheung ,  Daniel J. Parks ,  William H. Parsons ,  Sharmila Patel ,  Mark R. Player

Inventor： Wing S. Cheung ,  Daniel J. Parks ,  William H. Parsons ,  Sharmila Patel ,  Mark R. Player

IPC: A61K31/4184 ,  C07D235/12

CPC classification number: C07D235/12 ,  C07D235/06 ,  C07D235/14 ,  C07D235/26 ,  C07D235/30 ,  C07D401/12 ,  C07D405/12

Abstract: The invention is directed to compounds of Formula (I): to pharmaceutical compositions containing such compounds and to methods of treatment using them.

Abstract translation: 本发明涉及式（I）的化合物：含有这些化合物的药物组合物和使用它们的治疗方法。

公开(公告)号：US20080146637A1

公开(公告)日：2008-06-19

申请号：US11954647

申请日：2007-12-12

Applicant: Wing S. Cheung ,  Daniel J. Parks ,  William H. Parsons ,  Sharmila Patel ,  Mark R. Player

Inventor： Wing S. Cheung ,  Daniel J. Parks ,  William H. Parsons ,  Sharmila Patel ,  Mark R. Player

IPC: A61K31/4184 ,  A61P29/00 ,  C07D235/12

CPC classification number: C07D235/12 ,  C07D235/06 ,  C07D235/14 ,  C07D235/26 ,  C07D235/30 ,  C07D401/12 ,  C07D405/12

Abstract: The invention is directed to compounds of Formula (I): to pharmaceutical compositions containing such compounds and to methods of treatment using them.

Abstract translation: 本发明涉及式（I）的化合物：含有这些化合物的药物组合物和使用它们的治疗方法。

公开(公告)号：US06214805B1

公开(公告)日：2001-04-10

申请号：US08962690

申请日：1997-11-03

Applicant: Paul F. Torrence ,  Robert Hugh Silverman ,  Nick Mario Cirino ,  Guiying Li ,  Wei Xiao ,  Mark R. Player

Inventor： Paul F. Torrence ,  Robert Hugh Silverman ,  Nick Mario Cirino ,  Guiying Li ,  Wei Xiao ,  Mark R. Player

IPC: A61K3170

CPC classification number: C12N15/1131 ,  A61K38/00 ,  A61K47/549 ,  C07H21/00 ,  C12N2310/31 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/3521

Abstract: The present invention relates to methods of inhibiting infection by RNA viruses with complexes of an activator of RNase L and an oligonucleotide that is capable of binding to the genome, antigenome or mRNAs of a negative strand RNA virus to specifically cleave the genomic or antigenomic RNA strand of the virus. In accordance with the present invention, the methods and complexes of the invention may be applied to target any negative strand RNA virus. The invention in one embodiment relates to a covalently linked complex of an oligonucleotide that is capable of binding to the genomic or antigenomic template RNA strand of a negative strand RNA virus and/or binding to an mRNA of a viral protein (an “antisense oligonucleotide”) coupled to an activator of RNase L. In a preferred embodiment of the present invention, the oligonucleotide component of the complex is complementary to a region of the viral genomic RNA strand characterized by repeated or consensus sequences.

Abstract translation: 本发明涉及通过RNA酶L的活化剂和能够结合到负链RNA病毒的基因组，反义基团或mRNA的寡核苷酸的复合物来抑制RNA病毒感染以特异性切割基因组或反基因组RNA链的方法 的病毒。 根据本发明，本发明的方法和复合物可以用于靶向任何负链RNA病毒。 一个实施方案中的本发明涉及能够结合负链RNA病毒的基因组或反基因组模板RNA链和/或与病毒蛋白的mRNA结合的寡核苷酸的共价连接的复合物（“反义寡核苷酸” ）与RNase L的活化剂偶联。在本发明的优选实施方案中，复合物的寡核苷酸组分与以重复或共有序列为特征的病毒基因组RNA链的区域互补。

公开(公告)号：US20110190344A1

公开(公告)日：2011-08-04

申请号：US13084705

申请日：2011-04-12

Applicant: Mark R. Player ,  Scott L. Dax ,  William H. Parsons ,  Michael Richard Brandt ,  Raul R. Calvo ,  Sharmila Patel ,  Jian Liu ,  Wing S. Cheung ,  Michele C. Jetter ,  Yu-Kai Lee ,  Mark A. Youngman ,  Wenxi Pan ,  Kenneth M. Wells ,  Derek A. Beauchamp

Inventor： Mark R. Player ,  Scott L. Dax ,  William H. Parsons ,  Michael Richard Brandt ,  Raul R. Calvo ,  Sharmila Patel ,  Jian Liu ,  Wing S. Cheung ,  Michele C. Jetter ,  Yu-Kai Lee ,  Mark A. Youngman ,  Wenxi Pan ,  Kenneth M. Wells ,  Derek A. Beauchamp

IPC: A61K31/4184 ,  C07D235/04 ,  C07D401/10 ,  A61K31/4709 ,  A61P25/00

CPC classification number: C07D401/06 ,  C07D235/08 ,  C07D403/06

Abstract: The invention is directed to compounds of Formula (I): to pharmaceutical compositions containing such compounds and to methods of treatment using them.

公开(公告)号：US07951829B2

公开(公告)日：2011-05-31

申请号：US11734984

申请日：2007-04-13

Applicant: Mark R. Player ,  Scott L. Dax ,  William H. Parsons ,  Michael Richard Brandt ,  Raul R. Calvo ,  Sharmila Patel ,  Jian Liu ,  Wing S. Cheung ,  Michele C. Jetter ,  Yu-Kai Lee ,  Mark A. Youngman ,  Wenxi Pan ,  Kenneth M. Wells ,  Derek A. Beauchamp

Inventor： Mark R. Player ,  Scott L. Dax ,  William H. Parsons ,  Michael Richard Brandt ,  Raul R. Calvo ,  Sharmila Patel ,  Jian Liu ,  Wing S. Cheung ,  Michele C. Jetter ,  Yu-Kai Lee ,  Mark A. Youngman ,  Wenxi Pan ,  Kenneth M. Wells ,  Derek A. Beauchamp

IPC: A01N43/52 ,  C07D235/00

CPC classification number: C07D401/06 ,  C07D235/08 ,  C07D403/06

Abstract: The invention is directed to compounds of Formula (I): to pharmaceutical compositions containing such compounds and to methods of treatment using them.

Abstract translation: 本发明涉及式（I）的化合物：含有这些化合物的药物组合物和使用它们的治疗方法。

公开(公告)号：US07728003B2

公开(公告)日：2010-06-01

申请号：US11519662

申请日：2006-09-12

Applicant: Mark R. Player ,  Hui Huang ,  Hu Huaping ,  Renee L. DesJarlais

Inventor： Mark R. Player ,  Hui Huang ,  Hu Huaping ,  Renee L. DesJarlais

IPC: A61K31/44 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: The invention addresses the current need for selective and potent protein tyrosine kinase inhibitors by providing potent inhibitors of c-fms kinase. The invention is directed to the novel compounds of Formula I: or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof, wherein: W, A, Y, n, Z, and R102 are described in the specification.

Abstract translation: 本发明通过提供c-fms激酶的有效抑制剂来解决当前对选择性和有效的蛋白酪氨酸激酶抑制剂的需要。 本发明涉及新的式I化合物或其溶剂合物，水合物，互变异构体或其药学上可接受的盐，其中：W，A，Y，n，Z和R 102在说明书中描述。

公开(公告)号：US20100113473A1

公开(公告)日：2010-05-06

申请号：US12582325

申请日：2009-10-20

Applicant: Mark R. Player ,  Jian Liu

Inventor： Mark R. Player ,  Jian Liu

IPC: A61K31/496 ,  C07D401/14 ,  A61P9/00 ,  A61P3/10 ,  A61P3/04 ,  A61P3/06 ,  A61P31/00 ,  A61P29/00 ,  A61P35/00

CPC classification number: C07D405/14

Abstract: An aryl amide compound of Formula (I): or a pharmaceutically acceptable form thereof is disclosed. The compound is an ACC inhibitor and therefore useful in treating an ACC-mediated condition.

Abstract translation: 公开了式（I）的芳基酰胺化合物或其药学上可接受的形式。 该化合物是ACC抑制剂，因此可用于治疗ACC介导的病症。

公开(公告)号：US07547702B2

公开(公告)日：2009-06-16

申请号：US10380908

申请日：2001-09-17

Applicant: Werner Mederski ,  Maria Devant, legal representative ,  Gerhard Barnickel ,  Sabine Bernotat-Danielowski ,  James Vickers ,  Bertram Cezanne ,  Daljit Dhanoa ,  Bao-Ping Zhao ,  James Rinker ,  Mark R. Player ,  Edward Jaegar ,  Richard Soll

Inventor： Ralf Devant

IPC: A61K31/517 ,  A61K31/535 ,  C07D239/72 ,  C07D413/12

CPC classification number: C07D239/94 ,  C07D239/95 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/14

Abstract: Quinazolines of the formula (I) in which R, R1, R2, R3, R4 and Y have the meaning indicated in Patent claim 1, and their salts or solvates as glycoprotein 1bIX antagonists.

Abstract translation: 其中R，R 1，R 2，R 3，R 4和Y具有专利权利要求1中所示含义的式（I）的喹唑啉及其作为糖蛋白1bIX拮抗剂的盐或溶剂合物。

公开(公告)号：US07446210B2

公开(公告)日：2008-11-04

申请号：US11257208

申请日：2005-10-24

Applicant: Tianbao Lu ,  Tho V. Thieu ,  Yu-Kai Lee ,  Daniel J. Parks ,  Thomas P. Markotan ,  Wenxi Pan ,  Karen L. Milkiewicz ,  Mark R. Player

Inventor： Tianbao Lu ,  Tho V. Thieu ,  Yu-Kai Lee ,  Daniel J. Parks ,  Thomas P. Markotan ,  Wenxi Pan ,  Karen L. Milkiewicz ,  Mark R. Player

IPC: C07D207/00 ,  C07D213/00 ,  C07D231/00 ,  C07D231/54 ,  C07D239/02 ,  C07D241/04 ,  C07D265/28 ,  C07D295/00 ,  C07D487/00

CPC classification number: C07D413/14 ,  C07D231/56 ,  C07D401/04 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D409/14 ,  C07D413/04 ,  C07D417/10

Abstract: The present invention is directed to novel compounds of Formula I: and forms and pharmaceutical compositions thereof, and the use thereof as inhibitors of Factor Xa.

Abstract translation: 本发明涉及式I的新型化合物及其形式和药物组合物，以及其作为因子Xa抑制剂的用途。

公开(公告)号：US07429603B2

公开(公告)日：2008-09-30

申请号：US10831216

申请日：2004-04-26

Applicant: Mark R. Player ,  Nand Baindur ,  Benjamin Brandt ,  Naresh Chadha ,  Raymond J. Patch ,  Davoud Asgari ,  Taxiarchis M. Georgiadis

Inventor： Mark R. Player ,  Nand Baindur ,  Benjamin Brandt ,  Naresh Chadha ,  Raymond J. Patch ,  Davoud Asgari ,  Taxiarchis M. Georgiadis

IPC: C07D405/02 ,  A61K31/445

CPC classification number: C07D213/81 ,  C07D231/38 ,  C07D265/02 ,  C07D307/68 ,  C07D307/71 ,  C07D405/12 ,  C07D491/04

Abstract: The invention is directed to compounds of Formulae I, II and III: wherein A, R1, R2, R3, R4, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

Abstract translation: 本发明涉及式I，II和III的化合物：其中A，R 1，R 2，R 3，R SUB 说明书中列出了X，Y和W，以及抑制蛋白酪氨酸激酶，特别是c-fms激酶的溶剂合物，水合物，互变异构体或其药学上可接受的盐。