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    PROCESS FOR THE PREPARATION OF DESLORATADINE
    11.
    发明申请
    PROCESS FOR THE PREPARATION OF DESLORATADINE 审中-公开
    制备DESLORATADINE的方法

    公开(公告)号：US20120101281A1

    公开(公告)日：2012-04-26

    申请号：US13258661

    申请日：2010-03-26

    Applicant: Balaguru Murugesan ,  Swargam Sathyanarayana ,  Mohan Prasad

    Inventor： Balaguru Murugesan ,  Swargam Sathyanarayana ,  Mohan Prasad

    IPC: C07D221/16

    CPC classification number: C07D401/04

    Abstract: The present invention provides a process for the preparation of desloratadine comprising contacting loratadine with a mixture of a weak inorganic base and sodium or potassium hydroxide in a ratio, ranging from 0.01 to 0.15 equivalents of sodium or potassium hydroxide per equivalent of weak inorganic base, in one or more suitable solvents) followed by isolation.

    Abstract translation: 本发明提供了一种制备去氯雷他定的方法，该方法包括使弱氯酸钠与弱无机碱和氢氧化钠或氢氧化钾的混合物的比例为0.01至0.15当量的氢氧化钠或氢氧化钾/当量的无机碱， 一种或多种合适的溶剂），然后分离。

    Process for the preparation of faropenem
    13.
    发明授权
    Process for the preparation of faropenem 失效
    制备法罗培南的方法

    公开(公告)号：US07977475B2

    公开(公告)日：2011-07-12

    申请号：US12089159

    申请日：2006-10-05

    Applicant: Neela Praveen Kumar ,  Mohan Prasad

    Inventor： Neela Praveen Kumar ,  Mohan Prasad

    IPC: C07D499/893

    CPC classification number: C07D499/893

    Abstract: The present invention is related to processes for the preparation of faropenem, which comprises treating the compound of Formula II, with an alkali metal salt of a substituted or unsubstituted C5-10 carboxylic acid and a catalytic amount of a palladium complex in the presence of an organic solvent, followed by the treatment of the reaction mixture of with water and a water miscible solvent, and isolating a hydrate of an alkali metal salt of faropenem from the reaction mass, wherein water is not removed from the reaction mixture in water treatment or isolation steps.

    Abstract translation: 本发明涉及制备法罗培南的方法，该方法包括在取代或未取代的C 5-10羧酸的碱金属盐和催化量的钯络合物的存在下处理式II化合物 有机溶剂，然后用水和水混溶性溶剂处理反应混合物，并从反应物质中分离法罗培南碱金属盐的水合物，其中在水处理或分离中不从反应混合物中除去水 脚步。

    BARIUM SALT OF BENZIMIDAZOLE DERIVATIVE
    15.
    发明申请
    BARIUM SALT OF BENZIMIDAZOLE DERIVATIVE 有权
    苯并咪唑衍生物的钡盐

    公开(公告)号：US20090259047A1

    公开(公告)日：2009-10-15

    申请号：US12467051

    申请日：2009-05-15

    Applicant: Yatendra KUMAR ,  Mahavir Singh Khanna ,  Mohan Prasad

    Inventor： Yatendra KUMAR ,  Mahavir Singh Khanna ,  Mohan Prasad

    IPC: C07D401/12

    CPC classification number: C07D401/12 ,  A61K31/4439

    Abstract: The invention relates to crystalline barium salt of (S)-omeprazole, which is (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole. The invention also relates to processes for preparing crystalline barium salt of (S)-omeprazole and pharmaceutical compositions that include the crystalline barium salt of (S)-omeprazole so prepared.

    Abstract translation: 本发明涉及（S） - 奥美拉唑的结晶钡盐，其为（S）-5-甲氧基-2 - [[（4-甲氧基-3,5-二甲基-2-吡啶基） - 甲基]亚磺酰基〕-1H 苯并咪唑。 本发明还涉及制备（S） - 奥美拉唑的结晶钡盐的方法和包括如此制备的（S） - 奥美拉唑的结晶钡盐的药物组合物。

    Processes for the Preparation of Substituted Sulfoxides
    17.
    发明申请
    Processes for the Preparation of Substituted Sulfoxides 有权
    制备取代的亚砜的方法

    公开(公告)号：US20080275245A1

    公开(公告)日：2008-11-06

    申请号：US11576867

    申请日：2005-10-04

    Applicant: Neela Praveen Kumar ,  Mahavir Singh Khanna ,  Mohan Prasad ,  Yatendra Kumar

    Inventor： Neela Praveen Kumar ,  Mahavir Singh Khanna ,  Mohan Prasad ,  Yatendra Kumar

    IPC: C07D401/12

    CPC classification number: C07D401/12

    Abstract: The present invention relates to a process for enantioselective synthesis of substituted pyridinylmethyl sulfinyl-benzimidazole of compound of Formula (I). The process includes enantioselective catalytic oxidation of a substituted pyridinylmethyl prochiral sulfide derivative of compound of Formula (II) with an oxidizing agent in the presence of a chiral transition metal complex and a base in the absence of an organic solvent.

    Abstract translation: 本发明涉及式（I）化合物的取代的吡啶基甲基亚磺酰基 - 苯并咪唑的对映选择性合成方法。 该方法包括式（II）化合物的取代的吡啶基甲基前手性硫化物衍生物在手性过渡金属络合物和碱的存在下，在不存在有机溶剂的情况下与氧化剂的对映选择性催化氧化。

    Stable lamotrigine pharmaceutical compositions and processes for their preparation
    19.
    发明申请
    Stable lamotrigine pharmaceutical compositions and processes for their preparation 审中-公开
    稳定的拉莫三嗪药物组合物及其制备方法

    公开(公告)号：US20070129549A1

    公开(公告)日：2007-06-07

    申请号：US10550173

    申请日：2004-03-22

    Applicant: Yatendra Kumar ,  Mohan Prasad ,  Asok Nath ,  Nitin Maheshwari

    Inventor： Yatendra Kumar ,  Mohan Prasad ,  Asok Nath ,  Nitin Maheshwari

    IPC: C07D211/06

    CPC classification number: C07D211/32 ,  A61K31/4465 ,  C07D213/50

    Abstract: The invention relates to processes for the preparation of piperidylmethyl-indanones, and to the use of these compounds as intermediates for the preparation of benzyl-piperidylmethyl-indanones which are active compounds for the treatment of CNS disorders. The invention also relates to a process for the preparation of donepezil or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions that include the donepezil or a pharmaceutically acceptable salt thereof.

    Abstract translation: 本发明涉及制备哌啶甲基 - 茚满酮的方法，以及这些化合物作为制备作为用于治疗CNS障碍的活性化合物的苄基 - 哌啶基甲基 - 茚满酮的中间体的用途。 本发明还涉及制备多奈哌齐或其药学上可接受的盐的方法，以及包含多奈哌齐或其药学上可接受的盐的药物组合物。

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