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    APPARATUS
    11.
    发明申请
    APPARATUS 有权

    公开(公告)号：US20220307132A1

    公开(公告)日：2022-09-29

    申请号：US17545783

    申请日：2021-12-08

    Applicant: Nanexa AB

    Inventor： Anders JOHANSSON ,  Mårten ROOTH ,  Joel HELLRUP

    IPC: C23C16/455 ,  A61J3/00 ,  B01J2/00 ,  B01J13/04 ,  B05B7/00 ,  C23C16/54 ,  C23C16/44

    Abstract: A reactor for forming fully coated particles having a solid core, the reactor comprises a reactor vessel which is configured to receive particles, and a gas phase coating mechanism that is configured to selectively introduce pulses of gas phase materials that form a coating on the particles. The reactor also includes a sieve (16) that is located within the reactor vessel, and a forcing means that is configured to force the particles through the sieve (16) in use. The sieve is configured to deagglomerate any particle aggregates formed in the reactor vessel upon forcing of the particles by the forcing means through the sieve.

    NEW INJECTABLE COMBINATION FORMULATION
    13.
    发明申请
    NEW INJECTABLE COMBINATION FORMULATION 有权

    公开(公告)号：US20250041208A1

    公开(公告)日：2025-02-06

    申请号：US18717160

    申请日：2022-12-08

    Applicant: NANEXA AB

    Inventor： Anders JOHANSSON ,  Mårten ROOTH ,  Joel HELLRUP ,  David WESTBERG

    IPC: A61K9/00 ,  A61K9/50 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5415 ,  A61K31/569 ,  A61K31/635 ,  A61K31/706

    Abstract: There is provided a pharmaceutical or veterinary formulation comprising: (a) a biologically-active agent in admixture with a pharmaceutically- or veterinarily-acceptable extended-release component; (b) an antiinflammatory agent; and (c) a pharmaceutically- or veterinarily-acceptable injectable carrier. An extended-release component may also be applied to the antiinflammatory agent. The formulation may provide for the delayed or sustained release of biologically active ingredient without producing an inflammatory response after injection, and s preferably provided in the form of: (1) a plurality of particles having a weight-, number-, or volume-based mean diameter that is between about 10 nm and about 700 μm, which particles comprise solid corms comprising a biologically-active agent coated with a coating comprising at least one coating material applied by way of a gas phase deposition technique; (2) which particles are suspended in a carrier system comprising a pharmaceutically-acceptable or veterinarily-acceptable vehicle; and (3) which formulation further includes an antiinflammatory agent, which is optionally in the form of particles that are coated with a coating comprising at least one coating material applied by way of a gas phase deposition technique. Said coated particles are preferably synthesized via atomic layer deposition.

    NEW COMPOSITION
    16.
    发明申请
    NEW COMPOSITION 有权

    公开(公告)号：US20230009472A1

    公开(公告)日：2023-01-12

    申请号：US17782564

    申请日：2019-12-06

    Applicant: Nanexa AB

    Inventor： Anders JOHANSSON ,  Mårten ROOTH ,  Joel HELLRUP

    IPC: A61K9/28 ,  A61K9/20 ,  A61K9/00 ,  A61K47/26 ,  A61K47/54 ,  A61K31/404

    Abstract: There is provided a composition comprising a plurality of particles of a weight-, number-, or volume-, based mean diameter that is between amount 10 nm and about 700 µm, which particles are made up of: (a) a solid core, which solid core preferably comprises a biologically active agent; (b) one or more discrete layers surrounding said core, said one or more layer s each comprising at least one separate coating material; and (c) a final overcoating layer of a coating material, which overcoating layer surrounds, encloses and/or encapsulates said core and said previously-applied layers of coating material, and which final layer is of a thickness that is less than said previously-applied layers. Said layers (b) and (c) are preferably applied by way of a gas phase coating technique, such as atomic layer deposition. When the cores comprise biologically active agent, the compositions may provide for the delayed or sustained release of said active agent without a burst effect.

    A SOLID NANOPARTICLE WITH INORGANIC COATING
    20.
    发明申请
    A SOLID NANOPARTICLE WITH INORGANIC COATING 审中-公开
    具有无机涂层的固体纳米颗粒

    公开(公告)号：US20160081945A1

    公开(公告)日：2016-03-24

    申请号：US14891398

    申请日：2014-05-23

    Applicant: NANEXA AB

    Inventor： Jan-Otto CARLSSON ,  Anders JOHANSSON ,  Marten ROOTH

    IPC: A61K9/51

    CPC classification number: A61K9/5192 ,  A61K9/5073 ,  A61K9/5115

    Abstract: A nanoparticle having a solid core comprising a biologically active substance, said core being enclosed by an inorganic coating, a method for preparing the nanoparticle, and the use of the nanoparticle in therapy. A kit comprising the nanoparticle and a pharmaceutical composition comprising the nanoparticle.

    Abstract translation: 具有包含生物活性物质的固体核的纳米颗粒，所述核被无机涂层包围，制备纳米颗粒的方法以及纳米颗粒在治疗中的用途。 包含纳米颗粒的试剂盒和包含纳米颗粒的药物组合物。

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