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    NEW PROCESS FOR THE MANUFACTURE OF PHARMACEUTICAL COMPOSITIONS
    1.
    发明申请
    NEW PROCESS FOR THE MANUFACTURE OF PHARMACEUTICAL COMPOSITIONS 有权

    公开(公告)号：US20230020272A1

    公开(公告)日：2023-01-19

    申请号：US17782734

    申请日：2020-12-04

    Applicant: NANEXA AB

    Inventor： Anders JOHANSSON ,  Marten ROOTH ,  Joel HELLRUP

    IPC: A61K9/50 ,  A61K31/706

    Abstract: There is provided a process for the preparation of composition in the form of a plurality of particles having a weight-, number-, and/or volume-based mean diameter that is between amount 10 nm and about 700 μm, which particles comprise: (a) solid cores, preferably comprising a biologically active agent; and (b) two or more sequentially applied, discrete layers, each of which comprises at least one separately applied coating material, and which two or more layers together surround, enclose and/or encapsulate said cores, which process comprises the sequential steps of: (1) applying an initial layer of at least one coating material to said solid cores by way of a gas phase deposition technique; (2) discharging the coated particles from the gas phase deposition reactor and subjecting the coated particles to agitation to disaggregate particle aggregates formed during step (1) by way of mechanical sieving technique; (3) reintroducing the disaggregated, coated particles from step (2) into the gas phase deposition reactor and applying a further layer of at least one coating material to the reintroduced particles; and (1) optionally repeating steps (2) and (3) one or more times to increase the total thickness of the at least one coating material that enclose(s) said solid core. The gas phase deposition technique is preferably atomic layer deposition. When the cores comprise biologically active agent, the compositions may provide for the delayed or sustained release of said active agent without a burst effect.

    A SOLID NANOPARTICLE WITH INORGANIC COATING
    5.
    发明申请
    A SOLID NANOPARTICLE WITH INORGANIC COATING 审中-公开
    具有无机涂层的固体纳米颗粒

    公开(公告)号：US20160081945A1

    公开(公告)日：2016-03-24

    申请号：US14891398

    申请日：2014-05-23

    Applicant: NANEXA AB

    Inventor： Jan-Otto CARLSSON ,  Anders JOHANSSON ,  Marten ROOTH

    IPC: A61K9/51

    CPC classification number: A61K9/5192 ,  A61K9/5073 ,  A61K9/5115

    Abstract: A nanoparticle having a solid core comprising a biologically active substance, said core being enclosed by an inorganic coating, a method for preparing the nanoparticle, and the use of the nanoparticle in therapy. A kit comprising the nanoparticle and a pharmaceutical composition comprising the nanoparticle.

    Abstract translation: 具有包含生物活性物质的固体核的纳米颗粒，所述核被无机涂层包围，制备纳米颗粒的方法以及纳米颗粒在治疗中的用途。 包含纳米颗粒的试剂盒和包含纳米颗粒的药物组合物。

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