-
公开(公告)号:US20250073219A1
公开(公告)日:2025-03-06
申请号:US18567452
申请日:2022-06-10
Applicant: NANEXA AB
Inventor: Joel HELLRUP , Jonas FRANSSON , Mårten ROOTH , Anders JOHANSSON , David WESTBERG , Erik LINDAHL
IPC: A61K31/454 , A61K9/50
Abstract: The invention relates to a plurality of coated particles containing a solid core containing one of the compounds lenalidomide and pomalidomide, or a pharmaceutically acceptable salt thereof. The core has a mean diameter of the between 0.1 pm and 50 pm. The core is a coated by a coating surrounding, enclosing and/or encapsulating the core. The coating contains a mixed oxide selected from the group consisting of iron oxide, zinc oxide, silicon oxide, titanium oxide, and aluminium oxide.
-
公开(公告)号:US20230020272A1
公开(公告)日:2023-01-19
申请号:US17782734
申请日:2020-12-04
Applicant: NANEXA AB
Inventor: Anders JOHANSSON , Marten ROOTH , Joel HELLRUP
IPC: A61K9/50 , A61K31/706
Abstract: There is provided a process for the preparation of composition in the form of a plurality of particles having a weight-, number-, and/or volume-based mean diameter that is between amount 10 nm and about 700 μm, which particles comprise: (a) solid cores, preferably comprising a biologically active agent; and (b) two or more sequentially applied, discrete layers, each of which comprises at least one separately applied coating material, and which two or more layers together surround, enclose and/or encapsulate said cores, which process comprises the sequential steps of: (1) applying an initial layer of at least one coating material to said solid cores by way of a gas phase deposition technique; (2) discharging the coated particles from the gas phase deposition reactor and subjecting the coated particles to agitation to disaggregate particle aggregates formed during step (1) by way of mechanical sieving technique; (3) reintroducing the disaggregated, coated particles from step (2) into the gas phase deposition reactor and applying a further layer of at least one coating material to the reintroduced particles; and (1) optionally repeating steps (2) and (3) one or more times to increase the total thickness of the at least one coating material that enclose(s) said solid core. The gas phase deposition technique is preferably atomic layer deposition. When the cores comprise biologically active agent, the compositions may provide for the delayed or sustained release of said active agent without a burst effect.
-
公开(公告)号:US20240261228A1
公开(公告)日:2024-08-08
申请号:US18567466
申请日:2022-06-10
Applicant: NANEXA AB
Inventor: Anders JOHANSSON , Mårten ROOTH , Erik LINDAHL
IPC: A61K9/50 , A61K31/405 , A61K31/706
CPC classification number: A61K9/5089 , A61K9/501 , A61K31/405 , A61K31/706
Abstract: There is provided a process for the preparation of composition in the form of a plurality of particles having a weight-, number-, and/or volume-based mean diameter that is between amount 10 nm and about 700 μm, which particles comprise: (a) solid cores, preferably comprising a biologically active agent; and (b) two or more sequentially applied, discrete layers, each of which comprises at least one separately applied coating material, and which two or more layers together surround, enclose and/or encapsulate said cores, which process comprises the sequential steps of: (1) applying an initial layer of at least one coating material to said solid cores by way of a gas phase deposition technique; (2) subjecting the coated particles to agitation to deagglomerate particle aggregates formed during step (1) by way of a sieving step; (3) applying a further layer of at least one coating material to the deagglomerated particles; and (4) optionally repeating steps (2) and (3) one or more times to increase the total thickness of the at least one coating material that enclose(s) said solid core, wherein at least one of the sieving steps comprises a vibrational sieving technique, in which the vibrational sieving technique comprises supplying electrical power to a vibration motor coupled to a sieve. The gas phase deposition technique is preferably atomic layer deposition. When the cores comprise biologically active agent, the compositions may provide for the delayed or sustained release of said active agent without a burst effect.
-
公开(公告)号:US11214865B2
公开(公告)日:2022-01-04
申请号:US16912599
申请日:2020-06-25
Applicant: Nanexa AB
Inventor: Anders Johansson , Mårten Rooth , Joel Hellrup
Abstract: A reactor for forming fully coated particles having a solid core, the reactor comprises a reactor vessel which is configured to receive particles, and a gas phase coating mechanism that is configured to selectively introduce pulses of gas phase materials that form a coating on the particles. The reactor also includes a sieve (16) that is located within the reactor vessel, and a forcing means that is configured to force the particles through the sieve (16) in use. The sieve is configured to deagglomerate any particle aggregates formed in the reactor vessel upon forcing of the particles by the forcing means through the sieve.
-
公开(公告)号:US20210121415A1
公开(公告)日:2021-04-29
申请号:US17096511
申请日:2020-11-12
Applicant: Nanexa AB
Inventor: Jan-Otto Carlsson , Anders Johansson , Marten Rooth
Abstract: A nanoparticle having a solid core comprising a biologically active substance, said core being enclosed by an inorganic coating, a method for preparing the nanoparticle, and the use of the nanoparticle in therapy. A kit comprising the nanoparticle and a pharmaceutical composition comprising the nanoparticle.
-
公开(公告)号:US11717491B2
公开(公告)日:2023-08-08
申请号:US17096511
申请日:2020-11-12
Applicant: Nanexa AB
Inventor: Jan-Otto Carlsson , Anders Johansson , Marten Rooth
CPC classification number: A61K9/5192 , A61K9/5073 , A61K9/5115
Abstract: A nanoparticle having a solid core comprising a biologically active substance, said core being enclosed by an inorganic coating, a method for preparing the nanoparticle, and the use of the nanoparticle in therapy. A kit comprising the nanoparticle and a pharmaceutical composition comprising the nanoparticle.
-
公开(公告)号:US20210169815A1
公开(公告)日:2021-06-10
申请号:US17111873
申请日:2020-12-04
Applicant: Nanexa AB
Inventor: Anders Johansson , Joel Hellrup , Mårten Rooth
IPC: A61K9/50 , A61K9/48 , A61K31/706 , A61K9/00 , A61K9/06 , C23C16/40 , C23C16/455 , C23C16/44
Abstract: There is provided a process for the preparation of composition in the form of a plurality of particles having a weight-, number-, and/or volume-based mean diameter that is between amount 10 nm and about 700 μm, which particles comprise: (a) solid cores, preferably comprising a biologically active agent; and (b) two or more sequentially applied, discrete layers, each of which comprises at least one separately applied coating material, and which two or more layers together surround, enclose and/or encapsulate said cores, which process comprises the sequential steps of: (1) applying an initial layer of at least one coating material to said solid cores by way of a gas phase deposition technique; (2) discharging the coated particles from the gas phase deposition reactor and subjecting the coated particles to agitation to disaggregate particle aggregates formed during step (1) by way of mechanical sieving technique; (3) reintroducing the disaggregated, coated particles from step (2) into the gas phase deposition reactor and applying a further layer of at least one coating material to the reintroduced particles; and (4) optionally repeating steps (2) and (3) one or more times to increase the total thickness of the at least one coating material that enclose(s) said solid core. The gas phase deposition technique is preferably atomic layer deposition. When the cores comprise biologically active agent, the compositions may provide for the delayed or sustained release of said active agent without a burst effect.
-
公开(公告)号:US20160184484A1
公开(公告)日:2016-06-30
申请号:US14896849
申请日:2014-05-28
Applicant: NANEXA AB
Inventor: Anders JOHANSSON , Marten ROOTH , Jan-Otto CARLSSON
CPC classification number: A61L29/106 , A61L29/14 , A61L29/143 , A61L29/16 , A61L2300/10 , A61L2300/404 , A61L2400/10 , A61L2420/02 , A61M25/0009 , A61M25/0045 , A61M2025/0046 , A61M2025/0062 , B05D5/08 , C09D7/20 , C10M103/00 , C10M111/02 , C10M2201/0873 , C10N2230/06 , C10N2240/66 , C10N2250/121
Abstract: The present invention relates to a method of forming a boric acid coating on a substrate surface and a vein catheter comprising said coating.
Abstract translation: 本发明涉及在基材表面上形成硼酸涂层的方法和包括所述涂层的静脉导管。
-
公开(公告)号:US20240277749A1
公开(公告)日:2024-08-22
申请号:US18568219
申请日:2022-06-10
Applicant: NANEXA AB
Inventor: Anders JOHANSSON , Mårten ROOTH , Erik LINDAHL , Joel HELLRUP , David WESTBERG
IPC: A61K31/706 , A61K9/00 , A61K9/10 , A61K9/50 , A61P35/00 , C23C16/40 , C23C16/455
CPC classification number: A61K31/706 , A61K9/0019 , A61K9/10 , A61K9/501 , A61K9/5073 , A61P35/00 , C23C16/407 , C23C16/45555
Abstract: There is provided a pharmaceutical formulation that is useful in the treatment of myelodysplastic syndrome, comprising a plurality of particles suspended in an aqueous carrier system, which particles: (a) have a weight-, number-, or volume-based mean diameter that is between amount 10 nm and about 700 μm; and (b) comprise solid cores comprising azacitidine, or a pharmaceutically-acceptable salt thereof, coated, at least in part, by a coating of inorganic material comprising mixture of: (i) zinc oxide; and (ii) one or more other metal and/or metalloid oxides, wherein the atomic ratio ((i):(ii)) is between at least 1:6 and up to and including about 6:1. Said mixed oxide coated particles are preferably synthesized via a gas phase coating technique, such as atomic layer deposition. The formulation may provide for the delayed or sustained release of azacitidine to treat myelodysplastic syndrome without a burst effect.
-
公开(公告)号:US20230157968A1
公开(公告)日:2023-05-25
申请号:US17919415
申请日:2021-04-16
Applicant: NANEXA AB
Inventor: Anders JOHANSSON , Mårten ROOTH , Joel HELLRUP
IPC: A61K9/51 , A61K31/706 , A61K9/50
CPC classification number: A61K9/5115 , A61K31/706 , A61K9/5192 , A61K9/501 , A61K9/5089 , A61K9/5123 , A61K9/0019
Abstract: There is provided a pharmaceutical or veterinary formulation comprising: (a) a plurality of particles having a weight-, number-, or volume-based mean diameter that is between amount 10 nm and about 700 μm, which particles comprise solid cores coated with zinc oxide; suspended in (b) an oleaginous carrier system comprising a pharmaceutically-acceptable or veterinarily-acceptable oil, which zinc oxide coated particles comprise: (1) solid cores comprising a biologically-active agent; (2) one or more discrete layers surrounding said cores, said one or more layers each comprising at least one separate zinc oxide coating. Said zinc oxide coated particles are preferably synthesized via a gas phase coating technique, such as atomic layer deposition. When the cores comprise biologically-active agent, and the particles are suspended in an oleaginous carrier system, the formulation may provide for the delayed or sustained release of said active agent without a burst effect.
-
-
-
-
-
-
-
-
-