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公开(公告)号：US20200171051A1
公开(公告)日：2020-06-04
申请号：US16697808
申请日：2019-11-27
IPC分类号： A61K31/573 , A61K47/54 , A61K47/64
摘要： The present invention relates to methods for treating acute kidney injury that utilize a glucocorticoid prodrug. The glucocorticoid prodrug selectively delivers a glucocorticoid to the kidney, where it is capable of eliciting a p21 protective response. The present invention also contemplates several novel glucocorticoid prodrugs capable of use in the above manner.
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12.发明公开公开(公告)号：US20240226144A1
公开(公告)日：2024-07-11
申请号：US18407130
申请日：2024-01-08
摘要： Methods of treating patients before a scheduled insult such as surgy by administering a combination of stannic protoporfin and iron sucrose are provided. The present methods provide protection to photosensitive patients and those susceptible to post-operative complications.
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公开(公告)号：US11965896B2
公开(公告)日：2024-04-23
申请号：US17873968
申请日：2022-07-26
IPC分类号： G01N33/68 , A61K31/277 , A61K31/409 , A61K33/26
CPC分类号： G01N33/6893 , A61K31/277 , A61K31/409 , A61K33/26 , G01N2800/347
摘要： The p21 biomarker is utilized in the evaluation of whether a patient is suffering from kidney injury or failure, and can be used in methods of treating kidney injury or failure by determining the appropriateness of one or more of initiating renal replacement therapy, withdrawing delivery of compounds that are known to be damaging to the kidney, delaying or avoiding procedures that are known to be damaging to the kidney, and modifying diuretic administration.
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公开(公告)号：US20240108589A1
公开(公告)日：2024-04-04
申请号：US18530782
申请日：2023-12-06
CPC分类号： A61K31/12 , G01N33/6893 , G01N2800/7009
摘要： The present invention involves a novel method for treatment of chronic kidney disease comprising administering a compound that induces a stress protein response in a patient, and administering a potent antioxidant if the patent's response is below a predefined level. It also involves a quantitative measure for determining a patient's antioxidant reserve capacity.
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公开(公告)号：US11840552B2
公开(公告)日：2023-12-12
申请号：US17672072
申请日：2022-02-15
IPC分类号： C07H23/00 , A61K9/00 , A61K9/08 , A61K31/409
CPC分类号： C07H23/00 , A61K9/0019 , A61K9/08 , A61K31/409
摘要： The present invention involves a novel aqueous iron composition. The aqueous iron composition includes iron sucrose and bicarbonate. The aqueous iron composition of the invention exhibits enhanced renal protective effects relative to conventional iron sucrose compositions.
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公开(公告)号：US20210322340A1
公开(公告)日：2021-10-21
申请号：US17210205
申请日：2021-03-23
摘要： The present invention involves a novel method for treatment of chronic kidney disease comprising administering a compound that induces a stress protein response in a patient, and administering a potent antioxidant if the patent's response is below a predefined level. It also involves a quantitative measure for determining a patient's antioxidant reserve capacity.
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公开(公告)号：US20200057076A1
公开(公告)日：2020-02-20
申请号：US16422156
申请日：2019-05-24
IPC分类号： G01N33/68 , A61K31/277 , A61K33/26 , A61K31/409
摘要： The p21 biomarker is utilized in the evaluation of whether a patient is suffering from kidney injury or failure, and can be used in methods of treating kidney injury or failure by determining the appropriateness of one or more of initiating renal replacement therapy, withdrawing delivery of compounds that are known to be damaging to the kidney, delaying or avoiding procedures that are known to be damaging to the kidney, and modifying diuretic administration.
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公开(公告)号：US20240342191A1
公开(公告)日：2024-10-17
申请号：US18747522
申请日：2024-06-19
IPC分类号： A61K31/555 , A61K47/18 , A61K47/26 , A61P31/12
CPC分类号： A61K31/555 , A61K47/18 , A61K47/26 , A61P31/12
摘要： The inactivation of BK virus in patients diagnosed with BK virus, those receiving a kidney that is infected or suspected of being infected by BK virus, or in the transplanted kidney before, during, and/or after transplant surgery is described.
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公开(公告)号：US20230314448A1
公开(公告)日：2023-10-05
申请号：US17873968
申请日：2022-07-26
IPC分类号： A61K31/277 , A61K31/409 , G01N33/68 , A61K33/26
CPC分类号： G01N33/6893 , A61K31/277 , A61K31/409 , A61K33/26 , G01N2800/347
摘要： The p21 biomarker is utilized in the evaluation of whether a patient is suffering from kidney injury or failure, and can be used in methods of treating kidney injury or failure by determining the appropriateness of one or more of initiating renal replacement therapy, withdrawing delivery of compounds that are known to be damaging to the kidney, delaying or avoiding procedures that are known to be damaging to the kidney, and modifying diuretic administration.
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公开(公告)号：US20230070012A1
公开(公告)日：2023-03-09
申请号：US17979490
申请日：2022-11-02
摘要： The present invention involves a novel aqueous iron composition. The aqueous iron composition includes iron sucrose and bicarbonate. The aqueous iron composition of the invention exhibits enhanced renal protective effects relative to conventional iron sucrose compositions.
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