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公开(公告)号：US11826398B2
公开(公告)日：2023-11-28
申请号：US17326561
申请日：2021-05-21
Applicant: University of Washington
Inventor： Valerie Daggett , Alissa Bleem
IPC: A61K38/02 , A61K38/16 , A61L27/34 , A61L29/08 , A61L31/10 , C07K16/00 , A61K9/70 , A61P31/04 , A61L27/22 , A61L27/54 , A61L31/16 , A61L29/16 , A61P41/00
CPC classification number: A61K38/16 , A61K9/70 , A61K38/02 , A61L27/22 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61P31/04 , A61P41/00 , A61L2202/24 , A61L2300/25 , A61L2300/252 , A61L2300/404 , A61L2300/606 , A61L2420/02 , C07K16/00
Abstract: Disclosed herein are α-sheet peptides and their use for treating a bacterial infection and/or limiting bacterial biofilm formation.
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公开(公告)号：US20230241029A1
公开(公告)日：2023-08-03
申请号：US18002963
申请日：2019-12-03
Applicant: Kristoffer Hellstrand , Anna Martner
Inventor： Kristoffer Hellstrand , Anna Martner
IPC: A61K31/417 , A61P35/04 , A61P41/00 , A61P29/00
CPC classification number: A61K31/417 , A61P35/04 , A61P41/00 , A61P29/00
Abstract: Some embodiments of the methods and compositions provided herein include methods of reducing surgery-induced metastases in a subject with cancer following surgery to remove at least one solid tumor, comprising an NADPH oxidase inhibitor to said subject.
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公开(公告)号：US20230158119A1
公开(公告)日：2023-05-25
申请号：US18096087
申请日：2023-01-12
Applicant: Omrix Biopharmaceuticals Ltd.
Inventor： INBAR GAHALI-SASS , ISRAEL NUR , EREZ ILAN , RONEN EAVRI
CPC classification number: A61K38/363 , A61K38/4833 , A61P41/00 , A61K38/37 , A61K9/08 , C12Y304/21005 , A61P7/04 , A61K33/06 , A61K38/366 , A61K38/38
Abstract: Disclosed herein is an anti-adhesion kit comprised of: (i) a fibrinogen solution component comprising: fibrinogen at a concentration of about 5 to 25 mg/ml; and free calcium ions at a concentration ranging from 0.1 μM to 1 mM; and (ii) a thrombin component containing thrombin. Further disclosed is an anti-adhesion kit comprised of: (i) a fibrinogen solution component containing fibrinogen at a concentration of 8% to 25% of total protein by weight, and optionally free calcium ions at a concentration ranging from 0.1 μM to 1 mM; wherein a total protein concentration ranges from about 80 to 120 mg/ml; and (ii) a thrombin component containing thrombin. Methods of using the kits e.g., to provide anti-adhesion curable compositions are also disclosed.
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4.发明公开公开(公告)号：US20230158015A1
公开(公告)日：2023-05-25
申请号：US17802956
申请日：2021-03-03
Applicant: Gina E. VOTTA-VELLIS , SINTETICA S.A.
Inventor： AUGUSTO MITIDIERI , ELISABETTA DONATI , ALAIN BORGEAT , E. GINA VOTTA-VELIS , MIRO VENTURI
IPC: A61K31/485 , A61K31/167 , A61K9/00 , A61P41/00 , A61P35/00 , A61P25/04 , A61P29/00 , A61P35/04 , A61P1/18
CPC classification number: A61K31/485 , A61K9/0019 , A61K31/167 , A61P1/18 , A61P25/04 , A61P29/00 , A61P35/00 , A61P35/04 , A61P41/00
Abstract: Combinations of compounds that inhibit activation of p-Src tyrosine kinase, having particularly utility in the treatment of inflammation resulting from traumatic surgical interventions and the proliferation or metastasis of cancer cells following surgical excision of cancerous tissue.
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公开(公告)号：US20190185556A1
公开(公告)日：2019-06-20
申请号：US16323470
申请日：2017-08-07
Applicant: AMGEN INC. , WASHINGTON UNIVERSITY
Inventor： Michael S. Ominsky , Stavros Thomopoulos
CPC classification number: C07K16/22 , A61K38/00 , A61K39/3955 , A61K2039/505 , A61K2039/545 , A61L27/22 , A61L27/56 , A61P41/00 , C07K2317/76
Abstract: The application provides method for enhancing connective tissue-to-bone healing in a subject in need thereof comprising administering to the subject an anti-sclerostin antibody in an amount effective to enhance connective tissue-to-bone healing in the subject.
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Patent Agency Ranking
公开(公告)号：US20180021482A1
公开(公告)日：2018-01-25
申请号：US15548004
申请日：2016-02-25
Inventor： Yasuyuki ISONO , Yasuharu NOISHIKI
IPC: A61L31/04
CPC classification number: A61L31/041 , A61L15/64 , A61L31/042 , A61L31/12 , A61L31/148 , A61L2300/236 , A61L2300/424 , A61P41/00 , C08L1/26 , C08L5/04 , C08L5/08
Abstract: There is provided a medical/cosmetic material that retains the properties which are inherent in a polyanionic polysaccharide being a raw material, that has a high level of safety because there is no need to use a chemical crosslinking agent during production, and that makes it possible to place a powder of a water-insoluble polyanionic polysaccharide at an affected area uniformly. The medical/cosmetic material includes a base and a powder dispersed in the base, in which the base contains a water-soluble salt of a first polyanionic polysaccharide, and the powder is formed by water-insolubilizing a powder of a water-soluble salt of a second polyanionic polysaccharide with a treatment liquid containing an acid anhydride.
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7.发明申请公开(公告)号：US20120315254A1
公开(公告)日：2012-12-13
申请号：US13580381
申请日：2011-02-23
Applicant: Saher Hamed
Inventor： Saher Hamed
CPC classification number: A61K35/35 , A61K8/64 , A61K9/0019 , A61K38/1816 , A61K2800/91 , A61P17/02 , A61P41/00 , A61Q19/08 , A61K2300/00
Abstract: A method of enhancing fat cell survival in a subject in need thereof is disclosed. The method comprising (a) implanting a population of fat cells into the subject; and (b) administering Erythropoietin to the subject, thereby enhancing fat cell survival in the subject.
Abstract translation: 公开了一种在有需要的受试者中增强脂肪细胞存活的方法。 该方法包括（a）将一群脂肪细胞植入受试者; 和（b）向受试者施用促红细胞生成素，从而增强受试者的脂肪细胞存活。
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公开(公告)号：US20240327510A1
公开(公告)日：2024-10-03
申请号：US18290815
申请日：2022-07-22
Applicant: SHANGHAI SYNVIDA BIOTECHNOLOGY CO. LTD.
Inventor： Junling LIU , Xuemei FAN , Yanjun LIU
CPC classification number: C07K16/28 , A61K31/737 , A61K38/177 , A61P41/00 , G01N33/5023 , A61K2039/505 , C07K2317/565 , C07K2317/75 , G01N2333/705
Abstract: Provided is a drug for preventing, alleviating or treating adhesion and a use thereof. A fibroblast which has been subjected to external stimulation in a body cavity contains an activated negative regulatory receptor PEAR1. The deletion of the fibroblast PEAR1 can significantly promote in vivo mucosal adhesion formation. A PEARI agonist can specifically inhibit fibroblast activation, synthesize an extracellular matrix, and ameliorate the adhesion lesion. By administering the PEARI agonist, the formation of adhesion can be effectively prevented. Also provided is a PEARI agonistic antibody that does not affect the repair and healing of normal tissue and does not cause the tissue to be in an anoxic state. Moreover, the antibody drug has a long half-life, is easily diffused, has few side effects, and has a convenient route of administration.
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公开(公告)号：US12097179B2
公开(公告)日：2024-09-24
申请号：US17516556
申请日：2021-11-01
Applicant: Raziel Therapeutics Ltd.
Inventor： Shmuel Ben-Sasson
CPC classification number: A61K31/403 , A61K9/0014 , A61K9/0024 , A61K9/0029 , A61K31/14 , A61K45/06 , A61P17/02 , A61P41/00
Abstract: The invention provides carbazole derivatives for the treatment of fibrotic diseases (pathological collagen deposition) in tissues and organs, and related symptoms, and conditions thereof.
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公开(公告)号：US20240050517A1
公开(公告)日：2024-02-15
申请号：US18491099
申请日：2023-10-20
Applicant: University of Washington
Inventor： Valerie DAGGETT , Alissa BLEEM
IPC: A61K38/16 , A61K9/70 , A61P31/04 , A61L27/22 , A61L27/54 , A61L31/16 , A61L29/16 , A61K38/02 , A61L29/08 , A61L31/10 , A61P41/00 , A61L27/34
CPC classification number: A61K38/16 , A61K9/70 , A61P31/04 , A61L27/22 , A61L27/54 , A61L31/16 , A61L29/16 , A61K38/02 , A61L29/085 , A61L31/10 , A61P41/00 , A61L27/34 , A61L2300/252 , A61L2420/02 , A61L2202/24 , A61L2300/25 , A61L2300/606 , A61L2300/404 , C07K16/00
Abstract: Disclosed herein are α-sheet peptides and their use for treating a bacterial infection and/or limiting bacterial biofilm formation.
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