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15 条记录 (耗时 0.014 秒)

    Video camera device
    11.
    发明授权
    Video camera device 有权
    摄像机设备

    公开(公告)号：US06707619B1

    公开(公告)日：2004-03-16

    申请号：US09442918

    申请日：1999-11-18

    申请人： Satoshi Okuno

    发明人： Satoshi Okuno

    IPC分类号： G02B1514

    CPC分类号： G08B13/19632 ,  G03B37/00 ,  G08B13/19619 ,  G08B13/1963 ,  H04N7/18

    摘要： The invention is aimed to miniaturize an angle adjustment mechanism of a mirror barrel and simplify the structure thereof. A ball joint mechanism in which a spherical portion provided to the base end of a mirror barrel is joined to a spherical portion support table provided to a main chassis by a joint ring is constructed, and the rotation of the mirror barrel in three axial directions around the center of the spherical portion can be performed.

    摘要翻译： 本发明的目的在于使镜筒的角度调节机构小型化并简化其结构。 一种球接头机构，其中设置在镜筒的基端的球形部分通过接合环接合到设置在主底架上的球形支撑台，并且镜筒在三个轴向方向上的旋转 可以执行球形部分的中心。

    N-acetylcarboxymethylchitosan derivatives and process for preparation thereof
    12.
    发明授权
    N-acetylcarboxymethylchitosan derivatives and process for preparation thereof 失效

    公开(公告)号：US5463022A

    公开(公告)日：1995-10-31

    申请号：US969307

    申请日：1993-02-16

    申请人： Kazuhiro Inoue ,  Teruomi Ito ,  Satoshi Okuno ,  Katsutoshi Aono

    发明人： Kazuhiro Inoue ,  Teruomi Ito ,  Satoshi Okuno ,  Katsutoshi Aono

    IPC分类号： A61K47/48 ,  C08B37/08 ,  A61K38/00 ,  C07G17/00 ,  C07K9/00 ,  C08B37/00

    CPC分类号： C08B37/003

    摘要： N-acetylcarboxymethylchitosan derivatives are provided by the present invention. They are represented by the following formula (I): ##STR1## wherein R.sub.1 and R.sub.2 individually mean H or carboxymethyl group; P denotes a group R.sub.3 CO--, a group R.sub.4 NH-- or a group R.sub.5 O-- with assuming that R.sub.3 COOH denotes a compound having carboxyl group, R.sub.4 NH.sub.2 denotes a compound having amino group and R.sub.5 OH denotes an alcohol compound; Q stands for H or a group --OH; X represents a peptide chain containing same or different, one to ten amino acids; a.sub.1 and a.sub.2 individually represent zero or a positive integer, provided that both of a.sub.1 and a.sub.2 are not zero at the same time, and b stands for a positive integer; and having the following characteristic values (1)-(4):______________________________________ (1) carboxymethylation degree: 0.5-1.2 (2) molecular weight (as measured 3,000-300,000 by gel filtration method): (3) a/(a + b): 0.01-1 [provided that a = a.sub.1 + a.sub.2 ] (4) P/X ratio (molar ratio): 0.1-1 ______________________________________ P in the formula (I) can be the residue of a pharmaceutical compound. In this case, the substances of the formula (I) are derivatives of the pharmaceutical compound, which derivatives have been improved in the properties such as organotropism in vivo.P in the formula (I) can also be protective groups. In this case, removal of the protective groups from the substances of the formula (I) by deprotection makes it possible to provide such N-acetylcarboxymethylchitosan derivative which is useful as carrier for pharmaceutical compounds and which has the terminals of the so deprotected peptide chains capable of being linked with a pharmaceutical compound.There are further obtained such derivatives of the substances of the formula (I), in which derivatives some of the N-acetylcarboxymethylglucosamine units have been replaced by units having a high solubility in water.

    Camptothecin derivatives
    13.
    发明授权
    Camptothecin derivatives 失效
    喜树碱衍生物

    公开(公告)号：US06512118B1

    公开(公告)日：2003-01-28

    申请号：US09227158

    申请日：1999-01-08

    申请人： Kenji Tsujihara ,  Takayuki Kawaguchi ,  Satoshi Okuno ,  Toshiro Yano

    发明人： Kenji Tsujihara ,  Takayuki Kawaguchi ,  Satoshi Okuno ,  Toshiro Yano

    IPC分类号： C07D47100

    CPC分类号： C08B37/0018 ,  A61K47/61 ,  A61K47/65 ,  C08B37/0021

    摘要： A camptothecin derivative comprising a compound of the formula [I] is disclosed: wherein R1, R2, R3, R4 and R5 are (A) adjacent two groups combine to form alkylene, or both are H, and one of the remaining three groups is —Xn-Alkm-R6, and the other two are H, alkyl or halogen, or (B) adjacent two groups combine to form alkylene, and one of the carbon atoms of said alkylene group is substituted by —Xn-Alkm-R6, and the remaining three groups are H, alkyl or a halogen, and one or two —CH2— of the alkylene in (A) or (B) may optionally be replaced by —O—, —S— or —NH—, X is —O— or —NH—, Alk is alkylene, R6 is —NH2, or —OH, m and n are both 0 or 1, or m is 1 and n is 0, which camptothecin compound is bound to a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable salt thereof. Said camptothecin derivatives show enhanced antitumor activities but few side effects and are useful as a medicament.

    摘要翻译： 公开了包含式[I]化合物的喜树碱衍生物：其中R1，R2，R3，R4和R5是（A）相邻的两个基团结合形成亚烷基，或两者都是H，其余三个基团之一是 -Xn-Alkm-R6，另外两个为H，烷基或卤素，或（B）相邻的两个基团结合形成亚烷基，所述亚烷基的一个碳原子被-Xn-Alkm-R6取代， 并且其余三个基团是H，烷基或卤素，并且（A）或（B）中亚烷基的一个或两个-CH 2可以任选地被-O - ， - S-或-NH-代替，X是 -O-或-NH-，Alk为亚烷基，R6为-NH2或-OH，m和n均为0或1，或m为1，n为0，喜树碱化合物与具有羧基的多糖结合 通过氨基酸或肽，或其药学上可接受的盐。 所述喜树碱衍生物显示出增强的抗肿瘤活性，但副作用很少，可用作药物。