公开(公告)号：US07851491B2

公开(公告)日：2010-12-14

申请号：US12399249

申请日：2009-03-06

Applicant: Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

Inventor： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

IPC: A61K31/4192 ,  C07D249/18

CPC classification number: C08G65/329 ,  A61K47/60 ,  C08G65/2609

Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.

Abstract translation: 一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自 具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为 氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

公开(公告)号：US06875841B2

公开(公告)日：2005-04-05

申请号：US10206955

申请日：2002-07-30

Applicant: Kenji Sakanoue ,  Kazuhiro Kubo ,  Syunsuke Ohashi ,  Chika Itoh

Inventor： Kenji Sakanoue ,  Kazuhiro Kubo ,  Syunsuke Ohashi ,  Chika Itoh

IPC: A61K47/48 ,  C08G65/22 ,  C08G65/325 ,  C08G65/329 ,  C08G65/332 ,  C08G65/333 ,  C08G65/34

CPC classification number: C08G65/33337 ,  A61K47/60 ,  C08G65/3255 ,  C08G65/329 ,  C08G65/3324 ,  C08G65/33303

Abstract: A polyoxyalkylene derivative is represented by formula (I): wherein Z represents a residue of a compound having 2 to 8 hydroxyl groups; AO represents an oxyalkylene group having 2 to 18 carbon atoms; n and m each represent an integer of 0 to 2000 provided that both n and m do not represent 0; a and b each represent an integer satisfying the relationships: 2≦a+b≦8 and 1≦b; R represents a hydrocarbon group having 1 to 30 carbon atoms; and X represents a divalent hydrocarbon group having 3 to 10 carbon atoms.

Abstract translation: 聚氧化烯衍生物由式（I）表示：其中Z表示具有2-8个羟基的化合物的残基; AO表示碳原子数2〜18的氧化烯基， n和m各自表示0〜2000的整数，条件是n和m都不表示0; a和b各自表示满足以下关系的整数：2 <= a + b <= 8和1 <= b; R表示碳原子数1〜30的烃基; X表示碳原子数3〜10的二价烃基。