公开(公告)号：US08034981B2

公开(公告)日：2011-10-11

申请号：US12942554

申请日：2010-11-09

Applicant: Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

Inventor： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

IPC: C07D249/18

CPC classification number: C08G65/329 ,  A61K47/60 ,  C08G65/2609

Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.

Abstract translation: 一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自 具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为 氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

公开(公告)号：US20100029899A1

公开(公告)日：2010-02-04

申请号：US12529043

申请日：2008-02-28

Applicant: Kenji Sakanoue ,  Hiroki Yoshioka ,  Tomohiro Shirosaki

Inventor： Kenji Sakanoue ,  Hiroki Yoshioka ,  Tomohiro Shirosaki

IPC: C08G67/00

CPC classification number: C08G65/2609 ,  A61K47/60 ,  C08G65/327 ,  C08G65/3317 ,  C08G65/3318 ,  C08G65/33337 ,  C08G65/33372 ,  C08G65/33396 ,  C08L2203/02

Abstract: An object of the present invention is to provide a novel multibranched polyoxyalkylene derivative, and an intermediate for the production thereof. Specifically, the object is to provide a multibranched polyoxyalkylene derivative which can keep a high activity of a bio-related substance modified with the multibranched polyoxyalkylene derivative and which can easily produce the modified substance; an intermediate thereof; and a bio-related substance to which the multibranched polyoxyalkylene derivative is bonded.The novel multibranched polyoxyalkylene derivative according to the invention is a polyoxyalkylene derivative (1) having a functional group reactive with a bio-related substance and the bio-related substance according to the invention has a structure modified with the above polyoxyalkylene derivative (1) by a reaction. Furthermore, the intermediate for the production of the novel multibranched polyoxyalkylene derivative according to the invention is a polyoxyalkylene derivative (A). wherein A1O and A2O independently represent an oxyalkylene group having 2 to 4 carbon atoms, m represents 20 to 500, n represents 15 to 700, R represents a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms, X represents a functional group reactive with a bio-related substance, and X1 represents a hydroxyl group which may be protected.

Abstract translation: 本发明的目的是提供一种新型的多分支聚氧化烯衍生物及其生产用中间体。 具体地说，本发明提供一种能够保持由多支化聚氧化烯衍生物改性的生物相关物质的高活性的多分支聚氧化烯衍生物，能够容易地生成改性物质。 其中间体; 和多支链聚氧化烯衍生物所结合的生物相关物质。 根据本发明的新型多支链聚氧化烯衍生物是具有与生物相关物质反应的官能团的聚氧化烯衍生物（1），根据本发明的生物相关物质具有通过上述聚氧化烯衍生物（1）改性的结构 一个反应。 此外，用于生产根据本发明的新型多支链聚氧化烯衍生物的中间体是聚氧化烯衍生物（A）。 其中，AlO和A2O独立地表示碳原子数2〜4的氧化烯基，m表示20〜500，n表示15〜700，R表示氢原子或碳原子数1〜20的烃基，X表示官能团的反应性 与生物相关物质，X1表示可被保护的羟基。

公开(公告)号：US07524875B2

公开(公告)日：2009-04-28

申请号：US11142255

申请日：2005-06-02

Applicant: Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

Inventor： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

IPC: A61K31/075 ,  A61K31/4015 ,  A61K31/4164 ,  A61K31/4192 ,  C07C43/11 ,  C07D207/444 ,  C07D233/64 ,  C07D249/04 ,  C07D487/06

CPC classification number: C08G65/329 ,  A61K47/60 ,  C08G65/2609

Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.

Abstract translation: 一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自 具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为 氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

公开(公告)号：US20060115450A1

公开(公告)日：2006-06-01

申请号：US11142683

申请日：2005-06-02

Applicant: Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

Inventor： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

IPC: A61K31/765 ,  C08F283/00

CPC classification number: C08G65/2609 ,  A61K47/48215 ,  A61K47/60 ,  C08G65/329 ,  C08G65/333

Abstract: A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the above oxyalkylene group added, m represents 10 to 1000, X represents a functional group capable of chemically reacting with a bio-related substance, and Y is a linker and represents an ether bond, an amide bond, a urethane bond, an ester bond, a secondary amino group, a carbonate bond, or an alkylene group containing these bonds, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn≦1.08 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.

Abstract translation: 含有式（1）化合物的聚亚烷基二醇衍生物：其中R为碳原子数为1〜24的烃基，OA 1和O 2各自为氧化烯 具有2至4个碳原子的基团，由R表示的基团在一个分子中彼此相同或不同，在一个分子中由OA 2表示的基团彼此相同或不同， m是上述氧化烯基的平均加成摩尔数，m表示10〜1000，X表示与生物相关物质发生化学反应的官能团，Y为连接基，表示醚键，酰胺键 氨基甲酸酯键，酯键，仲氨基，碳酸酯键或含有这些键的亚烷基，上述聚亚烷基二醇衍生物在凝胶渗透色谱中的多分散性Mw / Mn满足以下关系： -formulae description =“In-line Formulas”end =“lead”？> Mw / Mn <= 1.08 < in-line-formula description =“In-line Formulas”end =“tail”？>其中Mw表示重均分子量，Mn表示数均分子量。

公开(公告)号：US08003117B2

公开(公告)日：2011-08-23

申请号：US11142678

申请日：2005-06-02

Applicant: Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

Inventor： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

IPC: C07C41/00 ,  C07C43/00

CPC classification number: C08G65/333 ,  C08G65/2609 ,  C08G65/329

Abstract: A polyalkylene glycol derivative containing a compound of the formula (1): wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA2 is an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, the groups represented by OA2 are the same or different from each other in one molecule, m is an average number of moles of the oxyalkylene group added, m represents 10 to 1000, and X represents a functional group capable of chemically reactive with a bio-related substance, polydispersity Mw/Mn of the above polyalkylene glycol derivative in gel permeation chromatography satisfying the following relationship: Mw/Mn≦1.07 wherein Mw represents a weight average molecular weight and Mn represents a number average molecular weight.

Abstract translation: 含有式（1）化合物的聚亚烷基二醇衍生物：其中R为碳原子数1〜24的烃基，OA2为碳原子数2〜4的氧化烯基，由R表示的基团相同或不同， 在一个分子中，由一个分子表示的基团彼此相同或不同，m是加成的氧化烯基的平均摩尔数，m表示10〜1000，X表示能够 与生物相关物质化学反应，上述聚亚烷基二醇衍生物的多分散性Mw / Mn在凝胶渗透色谱中满足以下关系式：Mw / Mn＆nlE 1.07其中Mw表示重均分子量，Mn表示数均分子量。

公开(公告)号：US07851491B2

公开(公告)日：2010-12-14

申请号：US12399249

申请日：2009-03-06

Applicant: Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

Inventor： Ken-ichiro Nakamoto ,  Syunsuke Ohashi ,  Yuji Yamamoto ,  Kenji Sakanoue ,  Chika Itoh ,  Tohru Yasukohchi

IPC: A61K31/4192 ,  C07D249/18

CPC classification number: C08G65/329 ,  A61K47/60 ,  C08G65/2609

Abstract: A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.

Abstract translation: 一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基，OA1和OA2各自 具有2至4个碳原子的氧化烯基，由一个分子中由R表示的基团彼此相同或不同，并且由OA2表示的基团在一个分子中彼此相同或不同，n和m各自为 氧化烯基的平均加成摩尔数，n表示0〜1000，m表示10〜1000。

公开(公告)号：US20090202619A1

公开(公告)日：2009-08-13

申请号：US11816680

申请日：2006-02-17

Applicant: Hiroshi Kiwada ,  Tatsuhiro Ishida ,  Chika Ito ,  Kazuhiro Kubo ,  Kenji Sakanoue ,  Hiroshi Kikuchi

Inventor： Hiroshi Kiwada ,  Tatsuhiro Ishida ,  Chika Ito ,  Kazuhiro Kubo ,  Kenji Sakanoue ,  Hiroshi Kikuchi

IPC: A61K9/127 ,  C07F9/02 ,  A61K47/18

CPC classification number: C07K7/06 ,  A61K9/1271 ,  A61K47/60 ,  A61K47/62 ,  C07K5/0806 ,  C07K5/1008

Abstract: A polyoxyalkylene chain-containing lipid derivative, which is represented by the following formula (1): wherein L, Y, W, X1, X2, X3, OA, Z, m1, m2, m3, n1, n2 and n3 are as defined in the specification.

Abstract translation: 由下式（1）表示的含有聚氧化烯链的脂质衍生物：其中L，Y，W，X1，X2，X3，OA，Z，m1，m2，m3，n1，n2和n3如上所定义 在规范中。

公开(公告)号：US07162885B2

公开(公告)日：2007-01-16

申请号：US10991394

申请日：2004-11-19

Applicant: Kenji Sakanoue ,  Koji Hayase ,  Kazuo Tetsukawa ,  Shinya Onai

Inventor： Kenji Sakanoue ,  Koji Hayase ,  Kazuo Tetsukawa ,  Shinya Onai

IPC: A47F3/04

CPC classification number: A47F3/001 ,  A47F3/0408

Abstract: There is provided a showcase which can expand a goods mounting area of a rack within a range of no interference with cooling in a display room. The showcase comprises a display room surrounded with a transparent wall supported by support pillars erected at four corners of a bottom frame, and a door, a rack hung in the display room to display goods, a cold air outlet formed on one side of the bottom frame, and a cold air inlet formed on the other side of the bottom frame. A space between the transparent wall of the other side of the display room and the rack is narrower than a space between the transparent wall of one side of the display room and the rack.

Abstract translation: 提供了一种展示柜，其可以在不干扰展示室内的冷却的范围内扩展机架的货物安装区域。 该陈列柜包括一个展示室，它被一个透明的墙围起来，该透明墙由一个底架的四个角落的支柱支撑，一个门，挂在显示室中的展示货物的一个架子，一个形成在底部一侧的冷气出口 框架和形成在底架的另一侧上的冷气入口。 显示室的另一侧的透明壁与机架之间的空间比显示室的一侧的透明壁与机架之间的间隔窄。

公开(公告)号：US20050115286A1

公开(公告)日：2005-06-02

申请号：US10986900

申请日：2004-11-15

Applicant: Kenji Sakanoue

Inventor： Kenji Sakanoue

IPC: A47F3/00 ,  A47F3/04 ,  E05B73/00

CPC classification number: A47F3/0426 ,  A47F3/002 ,  A47F3/0408 ,  Y10T70/40

Abstract: There is provided a simply-structured showcase which can lock a door without damaging an appearance. The showcase comprises a door pivotally supported on one side of an opening of a display room constituted in a main body to close the opening to be freely opened, main body side key metal fittings rotatably mounted to a surface of the door side of the main body on the other side of the opening, and door side key metal fittings rotatably mounted to a surface of the main body side on a non-pivotal support side of the door. The key metal fittings comprise through-holes for lock insertion, and are usually positioned in a space between the main body and the door. Portions in which the through-holes are positioned are protruded outward from the space in a rotated state, and the through-holes match each other in the state.

Abstract translation: 提供了一种简单结构的展示柜，可以锁定门而不损坏外观。 该展示架包括一个可枢转地支撑在主体构成的显示室的开口的一侧上的门，以封闭可自由打开的开口，主体侧键金属配件可旋转地安装在主体的门侧的表面上 在开口的另一侧，门侧的金属配件可旋转地安装在主体侧表面的门的非枢转支承侧上。 关键金属配件包括用于锁定插入的通孔，并且通常位于主体和门之间的空间中。 通孔所在的部分以旋转状态从空间向外突出，并且通孔在该状态下相互匹配。

公开(公告)号：US06875841B2

公开(公告)日：2005-04-05

申请号：US10206955

申请日：2002-07-30

Applicant: Kenji Sakanoue ,  Kazuhiro Kubo ,  Syunsuke Ohashi ,  Chika Itoh

Inventor： Kenji Sakanoue ,  Kazuhiro Kubo ,  Syunsuke Ohashi ,  Chika Itoh

IPC: A61K47/48 ,  C08G65/22 ,  C08G65/325 ,  C08G65/329 ,  C08G65/332 ,  C08G65/333 ,  C08G65/34

CPC classification number: C08G65/33337 ,  A61K47/60 ,  C08G65/3255 ,  C08G65/329 ,  C08G65/3324 ,  C08G65/33303

Abstract: A polyoxyalkylene derivative is represented by formula (I): wherein Z represents a residue of a compound having 2 to 8 hydroxyl groups; AO represents an oxyalkylene group having 2 to 18 carbon atoms; n and m each represent an integer of 0 to 2000 provided that both n and m do not represent 0; a and b each represent an integer satisfying the relationships: 2≦a+b≦8 and 1≦b; R represents a hydrocarbon group having 1 to 30 carbon atoms; and X represents a divalent hydrocarbon group having 3 to 10 carbon atoms.

Abstract translation: 聚氧化烯衍生物由式（I）表示：其中Z表示具有2-8个羟基的化合物的残基; AO表示碳原子数2〜18的氧化烯基， n和m各自表示0〜2000的整数，条件是n和m都不表示0; a和b各自表示满足以下关系的整数：2 <= a + b <= 8和1 <= b; R表示碳原子数1〜30的烃基; X表示碳原子数3〜10的二价烃基。