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公开(公告)号：US20240228705A1
公开(公告)日：2024-07-11
申请号：US18171299
申请日：2023-02-17
发明人： Te-Chao Liao , Wei-Ru Huang , Hung-Yi Chang , Chia-Lin Liu
IPC分类号： C08G73/12 , C08G65/333 , C08G65/48 , C08K3/36 , C08K5/18 , C08K5/5425
CPC分类号： C08G73/12 , C08G65/33337 , C08G65/485 , C08K3/36 , C08K5/18 , C08K5/5425
摘要： A resin composition is provided, which includes diamine, a BMI resin, and a modified polyphenylene ether resin having a following structural formula:
wherein R represents a chemical group of a bisphenol compound located between two hydroxyphenyl functional groups thereof, and n is an integer ranging from 3 to 25.-
公开(公告)号：US10071160B2
公开(公告)日：2018-09-11
申请号：US15388676
申请日：2016-12-22
发明人： Helen M. Burt , Donald E. Brooks , Jayachandran N. Kizhakkedathu , Richard Liggins , Dechi Guan , Lu Ye , Clement Mugabe , Alan So , Martin E. Gleave , John K. Jackson , Rajesh Kumar Kainthan
IPC分类号： A61K47/10 , A61K33/24 , A61K31/407 , A61K31/337 , A61K9/51 , A61K47/34 , C08G65/34 , C08G65/48 , C08G83/00 , C08G65/333 , A61K47/60 , A61K9/00
CPC分类号： A61K47/10 , A61K9/0034 , A61K9/006 , A61K9/5146 , A61K31/337 , A61K31/407 , A61K33/24 , A61K47/34 , A61K47/60 , C08G65/33306 , C08G65/33337 , C08G65/34 , C08G65/48 , C08G83/005 , C08G83/006 , C08G2650/54
摘要： Herein are provided derivatized hyperbranched polyglycerols (“dHPGs”). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with C1C20 alkyl chains and a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one hydrophilic substituent. The dHPGs are for use as agents for the delivery of a drug or other biologically active moiety to the urinary tract, the digestive tract, the airways, the vaginal cavity and cervix and the peritoneal cavity to treat indications such as cancer, which may be useful in the treatment of or the manufacture of a medicament, in the preparation, of a pharmaceutical composition for the treatment of cancer, as a pre-treatment or co-treatment to improve drug uptake in a tissue. Furthermore, there are provided methods of making dHPGs.
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公开(公告)号：US09908972B2
公开(公告)日：2018-03-06
申请号：US14892267
申请日：2014-05-13
IPC分类号： C08G65/333 , C08G69/40 , C08G81/00 , C12N5/00 , C12M1/00
CPC分类号： C08G65/33389 , C08G65/333 , C08G65/33337 , C08G69/40 , C08G81/00 , C12M23/20 , C12M23/30 , C12N5/0068 , C12N2537/10
摘要： The present invention provides a photodegradable cross-linking agent capable of manufacturing a photodegradable gel, which has appropriate moisture content and water solubility as a cell carrier and has strength that makes it possible to construct a complicated three-dimensional microstructure. The photodegradable cross-linking agent of the present invention includes a main chain 2 which is composed of branched polyethylene glycol having three or more branched chains and a photodegradable benzyl group 3 which is disposed on the terminus of the branched chains, in which the benzyl group has an active ester group 4, which is reactive with an amino group or a hydroxyl group, and one or more nitro groups in a benzene ring.
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公开(公告)号：US20170273971A1
公开(公告)日：2017-09-28
申请号：US15618715
申请日：2017-06-09
IPC分类号： A61K31/4745 , C12N9/02 , C08G65/333
CPC分类号： A61K31/4745 , A61K47/60 , C08G65/332 , C08G65/333 , C08G65/33331 , C08G65/33337 , C08G65/33396 , C08G65/3342 , C08G65/3344 , C08G65/3348 , C08G2210/00 , C08G2650/32 , C08G2650/58 , C08L2203/02 , C12N9/0071 , C12Y114/11002
摘要： Methods and compositions are described for enhancing tissue regeneration or wound repair in a mammalian subject comprising a composition comprising (a) a proline hydroxylase inhibitor component or molecule that increases or upregulates HIF1a and (b) a carrier component comprising a hydrogel.
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公开(公告)号：US09675607B2
公开(公告)日：2017-06-13
申请号：US14544003
申请日：2014-11-13
IPC分类号： A61K47/48 , A61K31/4745 , C12N9/02 , C08G65/333
CPC分类号： A61K31/4745 , A61K47/48215 , A61K47/48784 , A61K47/60 , C08G65/332 , C08G65/333 , C08G65/33331 , C08G65/33337 , C08G65/33396 , C08G65/3342 , C08G65/3344 , C08G65/3348 , C08G2210/00 , C08G2650/32 , C08G2650/58 , C08L2203/02 , C12N9/0071 , C12Y114/11002
摘要： Methods and compositions are described for enhancing tissue regeneration or wound repair in a mammalian subject comprising a composition comprising (a) a proline hydroxylase inhibitor component or molecule that increases or upregulates HIF1a and (b) a carrier component comprising a hydrogel.
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公开(公告)号：US20160114040A1
公开(公告)日：2016-04-28
申请号：US14868148
申请日：2015-09-28
发明人： Helen M. Burt , Donald E. Brooks , Jayachandran N. Kizhakkedathu , Richard Liggins , Dechi Guan , Lu Ye , Clement Mugabe , Alan So , Martin E. Gleave , John K. Jackson , Rajesh Kumar Kainthan
IPC分类号： A61K47/10 , C08G65/48 , A61K31/407 , A61K31/337 , A61K33/24
CPC分类号： A61K47/10 , A61K9/0034 , A61K9/006 , A61K9/5146 , A61K31/337 , A61K31/407 , A61K33/24 , A61K47/34 , A61K47/60 , C08G65/33306 , C08G65/33337 , C08G65/34 , C08G65/48 , C08G83/005 , C08G83/006 , C08G2650/54
摘要： Herein are provided derivatized hyperbranched polyglycerols (“dHPGs”). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with C1C20 alkyl chains and a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one hydrophilic substituent. The dHPGs are for use as agents for the delivery of a drug or other biologically active moiety to the urinary tract, the digestive tract, the airways, the vaginal cavity and cervix and the peritoneal cavity to treat indications such as cancer, which may be useful in the treatment of or the manufacture of a medicament, in the preparation, of a pharmaceutical composition for the treatment of cancer, as a pre-treatment or co-treatment to improve drug uptake in a tissue. Furthermore, there are provided methods of making dHPGs.
摘要翻译： 本文提供衍生的超支化聚甘油（“dHPG”）。 dHPG包含核心，其包含用C1C20烷基链衍生的超支化聚甘油和包含至少一个与核心羟基结合的亲水取代基的壳，其中超支化聚甘油包含约1至约200摩尔的至少一个亲水取代基 。 dHPG用作将药物或其他生物活性部分递送至尿路，消化道，气道，阴道腔和子宫颈以及腹膜腔以治疗诸如癌症的适应症的药剂，其可能是有用的 在制备中用于治疗癌症的药物组合物的治疗或制造中，作为用于改善组织中药物摄取的预处理或共处理。 此外，还提供了制备dHPG的方法。
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公开(公告)号：US08895759B2
公开(公告)日：2014-11-25
申请号：US14153783
申请日：2014-01-13
申请人： Nektar Therapeutics
IPC分类号： C07D207/46 , C07D403/12 , A61K47/48 , C08G65/333 , C08G69/08
CPC分类号： C07D403/12 , A61K47/60 , C08G65/33337 , C08G69/08
摘要： Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for preparing the intermediates, are also provided. Also provided are polymeric reagents, methods of using polymeric reagents, compounds and conjugates.
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公开(公告)号：US08865909B2
公开(公告)日：2014-10-21
申请号：US13130089
申请日：2009-11-19
IPC分类号： C07D277/34 , A01N43/76 , C08G65/334 , C07D207/448 , A01N43/50 , C08F228/06 , A01N37/32 , C08F222/40 , C08G65/333 , A01N43/78 , C08F220/14 , C08F220/56
CPC分类号： C07D277/34 , A01N37/32 , A01N43/50 , A01N43/76 , A01N43/78 , C07D207/448 , C08F220/14 , C08F220/56 , C08F222/40 , C08F228/06 , C08G65/33337 , C08G65/3348 , A01N43/653 , A01N2300/00
摘要： Novel agents exhibiting anti-biofilm formation activity while being non-cytotoxic are provided, as well as methods of using the same, either per se or conjugated to a polymer, for preventing and/or reducing the formation of microbial biofilms and/or for disrupting microbial biofilms. The novel agents described herein include thiazolidine-2,4-diones (TZDs), pyrrolidine-2,5-diones (PYDs), imidazolidine-2,4-diones or oxazolidine-2,4-diones, substituted by an alkyl having 7-20 carbon atoms in its backbone chain.
摘要翻译： 提供了表现出抗细胞毒性的抗生物膜形成活性的新型药剂，以及其本身或与聚合物共轭的方法，用于预防和/或减少微生物生物膜的形成和/或用于破坏 微生物生物膜。 本文所述的新型试剂包括噻唑烷-2,4-二酮（TZD），吡咯烷-2,5-二酮（PYD），咪唑烷-2,4-二酮或恶唑烷-2,4-二酮，其被具有7个 -20个碳原子在其主链。
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公开(公告)号：US08609857B2
公开(公告)日：2013-12-17
申请号：US13471064
申请日：2012-05-14
申请人： Kurt Breitenkamp , Kevin Sill , Habib Skaff
发明人： Kurt Breitenkamp , Kevin Sill , Habib Skaff
IPC分类号： C07D263/10
CPC分类号： C07C247/04 , A61K47/34 , C07C217/08 , C07C217/84 , C07C271/16 , C07D207/452 , C07D207/46 , C07D213/71 , C07D263/14 , C07D311/88 , C07D317/22 , C07D491/08 , C07D495/04 , C07F9/3808 , C07F9/4006 , C07F9/42 , C07F9/65502 , C07F9/65505 , C07F9/6552 , C08G65/2612 , C08G65/2627 , C08G65/263 , C08G65/325 , C08G65/329 , C08G65/3322 , C08G65/33303 , C08G65/33337 , C08G65/33396 , C08G65/3353 , C08G65/336 , C08G65/337 , C08G65/4006 , C08G2650/48 , C08L2203/02
摘要： The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.
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公开(公告)号：US08604159B2
公开(公告)日：2013-12-10
申请号：US10897386
申请日：2004-07-22
CPC分类号： C08G65/33337 , A61K47/60 , B01D15/361 , C08G65/00 , C08G65/30 , C08G65/322 , C08G65/323 , C08G65/329 , C08G65/3322 , C08G65/33306 , C08G65/33365 , C08G65/48 , C08G2650/38 , C08L2203/02
摘要： The present invention provides, among other things, methods for preparing functionalized and other polymers from polymer from polymer alcohols such as poly(ethylene glycol)s. In addition, polymer compositions, conjugates, polymeric reagents, are also provided.
摘要翻译： 本发明尤其提供了从聚合物醇如聚（乙二醇）的聚合物制备官能化和其它聚合物的方法。 此外，还提供了聚合物组合物，共轭物，聚合物试剂。
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