公开(公告)号：US20080182863A1

公开(公告)日：2008-07-31

申请号：US11909118

申请日：2006-03-27

Applicant: Kenneth Alan Simmen ,  Dominique Louis Nestor Ghislain Surleraux ,  Tse-I Lin ,  Oliver Lenz ,  Pierre Jean-Marie Bernard Raboisson ,  Sarvajit Chakravarty ,  Barry Patrick Hart

Inventor： Kenneth Alan Simmen ,  Dominique Louis Nestor Ghislain Surleraux ,  Tse-I Lin ,  Oliver Lenz ,  Pierre Jean-Marie Bernard Raboisson ,  Sarvajit Chakravarty ,  Barry Patrick Hart

IPC: A61K31/519 ,  C07D471/04 ,  A61P31/14

CPC classification number: C07D471/04 ,  A61K31/495

Abstract: Certain appropriately substituted fused bicyclic pyrimidine compounds having an amide-substituted pyridylamine group at C-4 of the pyrimidine ring are useful in the treatment of conditions associated with HCV.

Abstract translation: 在嘧啶环的C-4处具有酰胺取代的吡啶基胺基团的某些适当取代的稠合双环嘧啶化合物可用于治疗与HCV相关的病症。

公开(公告)号：US20130028865A1

公开(公告)日：2013-01-31

申请号：US13640657

申请日：2011-04-13

Applicant: Tse-I Lin ,  Oliver Lenz ,  Pierre Jean-Marie Bernard Raboisson

Inventor： Tse-I Lin ,  Oliver Lenz ,  Pierre Jean-Marie Bernard Raboisson

IPC: A61K31/55 ,  A61P31/14 ,  A61K38/21

CPC classification number: A61K31/4709 ,  A61K31/427 ,  A61K31/506 ,  A61K31/55 ,  A61K2300/00

Abstract: The present invention relates to a combination of a macrocyclic HCV protease inhibitor, a macrocyclic non-nucleoside HCV polymerase inhibitor and a nucleoside HCV polymerase inhibitor.

Abstract translation: 本发明涉及大环HCV蛋白酶抑制剂，大环非核苷HCV聚合酶抑制剂和核苷HCV聚合酶抑制剂的组合。

公开(公告)号：US07977342B2

公开(公告)日：2011-07-12

申请号：US11684288

申请日：2007-03-09

Applicant: Kenneth Alan Simmen ,  Tse-I Lin ,  Oliver Lenz ,  Dominique Louis Nestor Ghislain Surleraux ,  Pierre Jean-Marie Bernard Raboisson

Inventor： Kenneth Alan Simmen ,  Tse-I Lin ,  Oliver Lenz ,  Dominique Louis Nestor Ghislain Surleraux ,  Pierre Jean-Marie Bernard Raboisson

IPC: A01N43/54 ,  A01N43/90 ,  A61K31/517 ,  A61K31/519

CPC classification number: A61K31/517 ,  A61K31/519 ,  A61K31/52 ,  A61K31/53 ,  A61K31/5377 ,  Y02A50/385 ,  Y02A50/387

Abstract: The present invention relates to the use of bi-cyclic pyrimidines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or combat HCV infections. In addition, the present invention relates to processes for preparation of such pharmaceutical compositions. The present invention also concerns combinations of the present bi-cyclic pyrimidines with other anti-HCV agents.

Abstract translation: 本发明涉及双环嘧啶作为HCV复制抑制剂的用途，以及它们在旨在治疗或对抗HCV感染的药物组合物中的用途。 此外，本发明涉及这种药物组合物的制备方法。 本发明还涉及本发明的双环嘧啶与其它抗HCV药物的组合。

公开(公告)号：US20090247523A1

公开(公告)日：2009-10-01

申请号：US12443190

申请日：2007-10-04

Applicant: Pierre Jean-Marie Bernard Raboisson ,  Oliver Lenz ,  Tse-I Lin ,  Kenneth Simmen

Inventor： Pierre Jean-Marie Bernard Raboisson ,  Oliver Lenz ,  Tse-I Lin ,  Kenneth Simmen

IPC: A61K31/5377 ,  C07D401/12 ,  A61K31/506 ,  C07D413/14 ,  A61P31/12

CPC classification number: A61K31/506 ,  A61K31/535 ,  A61K2300/00

Abstract: The present invention relates to the use of carboxamide 4-[(4-pyridyl)amino]-pyrimidines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or combat HCV infections.

Abstract translation: 本发明涉及羧酰胺4 - [（4-吡啶基）氨基] - 嘧啶作为HCV复制的抑制剂的用途，以及它们在旨在治疗或对抗HCV感染的药物组合物中的用途。

公开(公告)号：US20070066622A1

公开(公告)日：2007-03-22

申请号：US10545453

申请日：2004-01-29

Applicant: Tobias Wunberg ,  Judith Baumeister ,  Ulrich Betz ,  Mario Jeske ,  Gerald Kleymann ,  Thomas Lampe ,  Susanne Nikolic ,  Jurgen Reefshlager ,  Rudolf Schohe-Loop ,  Frank Submeier ,  Holger Zimmermann ,  Rolf Grosser ,  Kerstin Henninger ,  Guy Hewlett ,  Jorg Keldenich ,  Thomas Kramer ,  Peter Nell ,  Tse-I Lin

Inventor： Tobias Wunberg ,  Judith Baumeister ,  Ulrich Betz ,  Mario Jeske ,  Gerald Kleymann ,  Thomas Lampe ,  Susanne Nikolic ,  Jurgen Reefshlager ,  Rudolf Schohe-Loop ,  Frank Submeier ,  Holger Zimmermann ,  Rolf Grosser ,  Kerstin Henninger ,  Guy Hewlett ,  Jorg Keldenich ,  Thomas Kramer ,  Peter Nell ,  Tse-I Lin

IPC: A61K31/517 ,  C07D405/14 ,  C07D403/02

CPC classification number: C07D239/84

Abstract: The invention relates to dihydroquinazolines and methods for the production thereof, the use thereof in the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments in the treatment and/or prophylaxis of diseases, especially for use as anti-viral agents, especially against cytomegalo viruses.

Abstract translation: 本发明涉及二氢喹唑啉及其制备方法，其用于治疗和/或预防疾病的用途，除了在制备药物中用于治疗和/或预防疾病，特别是用作 抗病毒剂，特别是针对巨细胞病毒。

公开(公告)号：US20090156595A1

公开(公告)日：2009-06-18

申请号：US11914018

申请日：2006-05-12

Applicant: Pierre Jean-Marie Bernard Raboisson ,  Dominique Louis Nestor Ghislain Surleraux ,  Tse-I Lin ,  Oliver Lenz ,  Kenneth Alan Simmen

Inventor： Pierre Jean-Marie Bernard Raboisson ,  Dominique Louis Nestor Ghislain Surleraux ,  Tse-I Lin ,  Oliver Lenz ,  Kenneth Alan Simmen

IPC: A61K31/5377 ,  A61K31/4985 ,  C07D475/00 ,  C07D413/14 ,  A61P31/12

CPC classification number: C07D475/10 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06 ,  C07D487/04 ,  Y02A50/385 ,  Y02A50/387 ,  A61K2300/00

Abstract: The present invention relates to the use of pteridines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or combat HCV infections. In addition, the present invention relates to compounds per se and their use as medicines. The present invention also concerns processes for the preparation of such compounds, pharmaceutical compositions comprising them, and combinations of said compounds with other anti-HCV agents.

Abstract translation: 本发明涉及使用蝶啶作为HCV复制的抑制剂，以及它们在旨在治疗或对抗HCV感染的药物组合物中的用途。 此外，本发明涉及化合物本身及其作为药物的用途。 本发明还涉及制备这些化合物的方法，包含它们的药物组合物以及所述化合物与其它抗HCV药剂的组合。

公开(公告)号：US20070004735A1

公开(公告)日：2007-01-04

申请号：US10541886

申请日：2003-12-24

Applicant: Ulrich Betz ,  Guy Hewlett ,  Gerald Kleymann ,  Thomas Lampe ,  Tse-I Lin ,  Susanne Nikolic ,  Jurgen Reefshlager ,  Tobias Wunberg ,  Holger Zimmerman ,  Franz Zumpe ,  Wolfgang Bender ,  Kerstin Henninger ,  Axel Jensen ,  Jorg Keldenich ,  Rudolf Schohe-Loop

Inventor： Ulrich Betz ,  Guy Hewlett ,  Gerald Kleymann ,  Thomas Lampe ,  Tse-I Lin ,  Susanne Nikolic ,  Jurgen Reefshlager ,  Tobias Wunberg ,  Holger Zimmerman ,  Franz Zumpe ,  Wolfgang Bender ,  Kerstin Henninger ,  Axel Jensen ,  Jorg Keldenich ,  Rudolf Schohe-Loop

IPC: C12Q1/70 ,  A61K31/50 ,  A61K31/17 ,  C07C271/28

CPC classification number: C07C311/08 ,  C07C275/40 ,  C07D237/04 ,  G01N33/56994 ,  G01N2500/00

Abstract: The invention relates to a method for inhibiting the replication of herpesviruses, to methods for identifying compounds which inhibit the replication of herpesviruses using this method, to compounds having activity against herpesviruses, to methods for their preparation and to their use for producing medicaments for the treatment of herpes infections.

Abstract translation: 本发明涉及一种抑制疱疹病毒复制的方法，用于鉴定使用该方法抑制疱疹病毒复制的化合物的方法，具有抗疱疹病毒活性的化合物，其制备方法及其用于制备治疗药物的用途 的疱疹感染。