公开(公告)号：US20060133959A1

公开(公告)日：2006-06-22

申请号：US11155584

申请日：2005-06-20

Applicant: Jiann-Hua Wang ,  Tsung-Kai Chuang ,  Tzu-Chiang Wu ,  Chien-Ho Chuang

Inventor： Jiann-Hua Wang ,  Tsung-Kai Chuang ,  Tzu-Chiang Wu ,  Chien-Ho Chuang

IPC: G01N21/64

CPC classification number: G01N21/253 ,  G01N21/76

Abstract: A luminometer includes a movable carrier carrying a number of luminescence collectors arranged in an array for simultaneously detecting the same number of samples received in multiple wells defined in a microplate. An optic fiber optically couples each luminescence detector to an associated charge-coupled device whereby a luminescence signal emitted from each sample is transmitted to the charge-coupled device and converted thereby into a corresponding electric signal. The charge-coupled devices are isolated from each other by partitions, which eliminate undesired interference among the luminescence signals transmitted to the charge-coupled device. A driving unit is provided to move the carrier between rows of the wells defined in the microplate.

Abstract translation: 发光计包括携带多个以阵列排列的发光收集器的可移动载体，用于同时检测在微板中限定的多个孔中接收的相同数量的样品。 光纤将每个发光检测器光耦合到相关联的电荷耦合器件，由此从每个样本发射的发光信号传输到电荷耦合器件，从而转换成相应的电信号。 电荷耦合器件通过分隔彼此隔离，这消除了传输到电荷耦合器件的发光信号之间的不期望的干扰。 提供了一个驱动单元，用于在微孔板中限定的孔的行之间移动载体。

公开(公告)号：US07042565B2

公开(公告)日：2006-05-09

申请号：US10777720

申请日：2004-02-13

Applicant: Jiann-Hua Wang ,  Hui Ju Chen ,  Tzu-Chiang Wu ,  Chien-Ho Chuang ,  Tsung-Kai Chuang

Inventor： Jiann-Hua Wang ,  Hui Ju Chen ,  Tzu-Chiang Wu ,  Chien-Ho Chuang ,  Tsung-Kai Chuang

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N2021/6417

Abstract: A fluorescent microarray analyzer includes a light source for emitting a light beam, a light processing unit for focusing the light beam on the biochip and exciting fluorescent targets on the biochip to produce fluorescence, a focusing lens for focusing the fluorescence on a spectrophotometer, a spectrophotometer for detecting signal of the fluorescence, and an output device for selectively outputting/displaying the signal detected by the spectrophotometer. The resulting signal of the output device does not need to be converted into image data for analysis. For acquiring a more accurate result of detection of signal of fluorescence from the fluorescent targets, the photomultiplier tube of the conventional biochip scanner device is replaced with the spectrophotometer of fluorescent microarray analyzer of the present invention and the filter is removed. Without converting the signal into an image, no errors arise as what happened in process of converting an electrical signal into image data in the conventional biochip. Also, a real-time analysis of the signal proceeds while scanning samples on the biochip.

Abstract translation: 荧光微阵列分析仪包括用于发射光束的光源，用于将光束聚焦在生物芯片上并激发生物芯片上的荧光靶产生荧光的光处理单元，用于将荧光聚焦在分光光度计上的聚焦透镜，分光光度计 用于检测荧光信号;以及输出装置，用于选择性地输出/显示由分光光度计检测的信号。 输出装置的结果信号不需要转换为图像数据进行分析。 为了从荧光靶获得更准确的荧光信号结果，用本发明的荧光微阵列分析仪的分光光度计代替常规生物芯片扫描器装置的光电倍增管，并除去滤光片。 在不将信号转换为图像的情况下，在传统生物芯片中将电信号转换为图像数据的过程中没有发生错误。 此外，在生物芯片上扫描样品时，信号的实时分析进行。

公开(公告)号：US20090275806A1

公开(公告)日：2009-11-05

申请号：US12114204

申请日：2008-05-02

Applicant: Tzu-Chiang Wu ,  Mao-Ji Lin ,  Chien-Ho Chuang ,  Tsung-Kai Chuang ,  Jiann-Hua Wang

Inventor： Tzu-Chiang Wu ,  Mao-Ji Lin ,  Chien-Ho Chuang ,  Tsung-Kai Chuang ,  Jiann-Hua Wang

IPC: A61B5/00

CPC classification number: A61B10/0096 ,  A61B10/0045

Abstract: The present invention relates to a portable biomedical detective device comprising a carrier, a detective unit disposed in the carrier, an operating unit for converting biomedical signals of the detection into digitalized results, a display unit shown the digitalized results, and a power supply to drive the detective unit, the operating unit and the display unit. Therefore, biomedical signals on a biomedical cassette can be detected and converted into digital results by the portable biomedical detective device, which is light for carrying easily.

Abstract translation: 本发明涉及便携式生物医学检测装置，其包括载体，设置在载体中的检测单元，用于将检测的生物医学信号转换为数字化结果的操作单元，显示数字化结果的显示单元和驱动的电源 检测单元，操作单元和显示单元。 因此，可以通过便携式生物医学检测装置检测生物医学盒上的生物医学信号并将其转换成数字结果，该装置轻便携带。

公开(公告)号：US20070253867A1

公开(公告)日：2007-11-01

申请号：US11542259

申请日：2006-10-04

Applicant: Tzu-Chiang Wu ,  Mao-Ji Lin ,  Chien-Ho Chuang ,  Tsung-Kai Chuang ,  Jiann-Hua Wang

Inventor： Tzu-Chiang Wu ,  Mao-Ji Lin ,  Chien-Ho Chuang ,  Tsung-Kai Chuang ,  Jiann-Hua Wang

IPC: G01N21/00

CPC classification number: G01N21/255 ,  G01N21/272 ,  G01N21/8483

Abstract: A cylindrical reagent chip analyzer, comprises a rotating seat with a sample collection device mounted thereon, a motor, an image receiver connected to a computer. The motor drives the rotating seat to rotate. A lens of the image receiver is focused on reagent chips on the sample collection device. The image receiver then takes the images of the reagent chips and inputs the image data into the computer. The testing results are obtained after a color code comparison program analyzes the taken images.

Abstract translation: 一种圆柱形试剂芯片分析仪，包括安装有样品收集装置的旋转座，马达，连接到计算机的图像接收器。 电机驱动旋转座椅旋转。 图像接收器的透镜聚焦在样品收集装置上的试剂芯片上。 然后，图像接收器接收试剂芯片的图像，并将图像数据输入计算机。 在颜色代码比较程序分析所拍摄的图像之后获得测试结果。

公开(公告)号：US20060114454A1

公开(公告)日：2006-06-01

申请号：US11002847

申请日：2004-12-01

Applicant: Tsung-Kai Chuang ,  Chien-Ho Chuang ,  Tzu-Chiang Wu

Inventor： Tsung-Kai Chuang ,  Chien-Ho Chuang ,  Tzu-Chiang Wu

IPC: G01N21/00

CPC classification number: G01N21/55 ,  G01N21/274 ,  G01N21/59 ,  G01N2021/558 ,  G01N2201/08

Abstract: Disclosed is a method for calibrating an optical component, such as a DWDM, a thin film filter, a collimator, and a wave-guide. The method includes the steps of projecting a laser beam through the optical component, detecting the transmitting power while moving the optical component until the transmitting power is maximum to determine a local area, and detecting the reflected power while moving the optical component with fine steps within the local area until the reflected power is minimum, where an optimum point is located, which gives the maximum transmitting power and minimum reflected power.

Abstract translation: 公开了一种用于校准诸如DWDM，薄膜滤光器，准直仪和波导之类的光学部件的方法。 该方法包括以下步骤：通过光学部件投射激光束，在移动光学部件的同时检测发射功率，直到发射功率最大以确定局部区域，并且在将光学部件以微细的步进移动的同时检测反射功率 局部区域，直到反射功率最小，其中存在最佳点，其给出最大发射功率和最小反射功率。

公开(公告)号：US20050179894A1

公开(公告)日：2005-08-18

申请号：US10777720

申请日：2004-02-13

Applicant: Jiann-Hua Wang ,  Hui Chen ,  Tzu-Chiang Wu ,  Chien-Ho Chuang ,  Tsung-Kai Chuang

Inventor： Jiann-Hua Wang ,  Hui Chen ,  Tzu-Chiang Wu ,  Chien-Ho Chuang ,  Tsung-Kai Chuang

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N2021/6417

Abstract: A fluorescent microarray analyzer includes a light source for emitting a light beam, a light processing unit for focusing the light beam on the biochip and exciting fluorescent targets on the biochip to produce fluorescence, a focusing lens for focusing the fluorescence on a spectrophotometer, a spectrophotometer for detecting signal of the fluorescence, and an output device for selectively outputting/displaying the signal detected by the spectrophotometer. The resulting signal of the output device does not need to be converted into image data for analysis. For acquiring a more accurate result of detection of signal of fluorescence from the fluorescent targets, the photomultiplier tube of the conventional biochip scanner device is replaced with the spectrophotometer of fluorescent microarray analyzer of the present invention and the filter is removed. Without converting the signal into an image, no errors arise as what happened in process of converting an electrical signal into image data in the conventional biochip. Also, a real-time analysis of the signal proceeds while scanning samples on the biochip.

Abstract translation: 荧光微阵列分析仪包括用于发射光束的光源，用于将光束聚焦在生物芯片上并激发生物芯片上的荧光靶产生荧光的光处理单元，用于将荧光聚焦在分光光度计上的聚焦透镜，分光光度计 用于检测荧光信号;以及输出装置，用于选择性地输出/显示由分光光度计检测的信号。 输出装置的结果信号不需要转换为图像数据进行分析。 为了从荧光靶获得更准确的荧光信号结果，用本发明的荧光微阵列分析仪的分光光度计代替常规生物芯片扫描器装置的光电倍增管，并除去滤光片。 在不将信号转换为图像的情况下，在传统生物芯片中将电信号转换为图像数据的过程中没有发生错误。 此外，在生物芯片上扫描样品时，信号的实时分析进行。