公开(公告)号：US20240353386A1

公开(公告)日：2024-10-24

申请号：US18684180

申请日：2022-03-18

申请人： Sony Group Corporation

发明人： Susumu TAKATSUKA ,  Hiroki TETSUKAWA

IPC分类号： G01N33/18 ,  G01N21/17 ,  G01N21/27 ,  G01N21/88

CPC分类号： G01N33/1846 ,  G01N21/272 ,  G01N21/8851 ,  G01N2021/1778 ,  G01N2021/8893

摘要： A measurement device includes an image capture control unit that causes an image capture unit to capture an image of a predetermined image capture range in water, and a carbon amount estimation unit that estimates an amount of carbon based on the image captured by the image capture unit.

公开(公告)号：US12092631B2

公开(公告)日：2024-09-17

申请号：US16903907

申请日：2020-06-17

申请人： The General Hospital Corporation

发明人： Seemantini K. Nadkarni ,  Zeinab Hajjarian ,  Markandey Tripathi ,  Diane Tshikudi

IPC分类号： G01N33/49 ,  B01L3/00 ,  G01N11/00 ,  G01N15/00 ,  G01N21/27 ,  G01N21/51 ,  G01N21/82 ,  G01N33/86 ,  G01N15/0205 ,  G01N21/47

CPC分类号： G01N33/4905 ,  B01L3/502715 ,  G01N11/00 ,  G01N15/00 ,  G01N21/272 ,  G01N21/51 ,  G01N21/82 ,  G01N33/86 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N2015/0092 ,  G01N2015/0222 ,  G01N2021/479 ,  G01N2021/825 ,  G01N2201/0221 ,  G01N2203/0094

摘要： Hand-held optical thromboelastographic sensor and method of using the same for simultaneous assessment of multiple parameters of blood coagulation at a point-of-care. The sensor includes an optical system registering laser speckle intensities associated with portions of a blood sample delivered through a fluid switch to analysis chambers of a cartridge of the sensor, and data-processing circuitry programmed to derive the multiple parameters from speckle intensity. The circuitry may be part of a mobile device configured to operate without communication with a central server and/or data storage.

公开(公告)号：US12030221B2

公开(公告)日：2024-07-09

申请号：US16998047

申请日：2020-08-20

申请人： Sealed Air Corporation (US)

发明人： George Bertram ,  Douglas Walker

IPC分类号： B29C44/18 ,  B01F23/20 ,  B01F23/40 ,  B01F23/70 ,  B01F35/00 ,  B01F35/21 ,  B01F35/214 ,  B01F35/22 ,  B01F35/221 ,  B01F35/513 ,  B01F35/71 ,  B01F35/92 ,  B29B7/74 ,  B29B7/76 ,  B29C44/34 ,  B29C65/00 ,  B29C65/18 ,  B67D7/02 ,  B67D7/36 ,  B67D7/62 ,  B67D7/76 ,  G01N21/27 ,  G01N21/35 ,  B01F35/90 ,  B01F101/00 ,  B67D7/74

CPC分类号： B29B7/7631 ,  B01F23/291 ,  B01F23/49 ,  B01F23/711 ,  B01F35/187 ,  B01F35/2113 ,  B01F35/2115 ,  B01F35/2144 ,  B01F35/2209 ,  B01F35/2215 ,  B01F35/513 ,  B01F35/7176 ,  B01F35/71805 ,  B01F35/92 ,  B29B7/7404 ,  B29B7/7615 ,  B29B7/7657 ,  B29B7/7689 ,  B29C44/182 ,  B29C44/3442 ,  B29C65/18 ,  B29C66/91421 ,  B67D7/0294 ,  B67D7/36 ,  B67D7/62 ,  B67D7/76 ,  G01N21/272 ,  G01N21/35 ,  B01F2035/99 ,  B01F2101/2204 ,  B67D7/743

摘要： A system for opening and closing a mixing manifold includes a drive motor, a cam plate, and a valving rod connector. The drive motor imparts movement in first and second directions. Movement imparted in the first direction causes the cam plate to move linearly in a third direction and movement imparted in the second direction causes the cam plate to move linearly in a fourth direction. Movement of the cam plate in the third direction causes the valving rod connector to move linearly in a fifth direction and movement of the cam plate in the fourth direction causes the valving rod connector to move linearly in a sixth direction. Movement of the valving rod connector in the fifth direction causes retraction of a valving rod of the mixing manifold and movement of the valving rod connector in the sixth direction causes extension of the valving rod.

公开(公告)号：US11988608B2

公开(公告)日：2024-05-21

申请号：US16633349

申请日：2018-08-06

申请人： INNOSPEC LIMITED

发明人： Philip Maltas

IPC分类号： G01N21/78 ,  G01N21/27 ,  G01N21/29 ,  G01N33/28

CPC分类号： G01N21/78 ,  G01N21/272 ,  G01N21/293 ,  G01N33/2823 ,  G01N33/287

摘要： A method for determining the presence of an acidic sulfide species in a liquid sample of an industrial or environmental material. The method includes the step of contacting the sample or an extract thereof with a composition including a metal complex dye compound in which the electromagnetic absorption spectrum of the metal complex dye compound changes upon reaction with an acidic sulfide species.

公开(公告)号：US11774356B2

公开(公告)日：2023-10-03

申请号：US17553323

申请日：2021-12-16

申请人： PROTEIN DYNAMIC SOLUTIONS, INC.

发明人： Belinda Pastrana-Rios

IPC分类号： G01N21/3554 ,  G01N21/27 ,  G01N21/552 ,  G01N21/17 ,  G01N21/35

CPC分类号： G01N21/3554 ,  G01N21/17 ,  G01N21/272 ,  G01N21/35 ,  G01N21/552 ,  G01N2021/3595

摘要： The disclosure relates to methods and systems for the analysis of compounds in a crystalline state and/or undergoing crystallization. Two-dimensional correlation (2DCOS) and co-distribution analysis (2DCDS) analysis plots can be generated and analyzed. Asynchronous plots can aid in establishing a sequential order of events. Positive cross peaks that correlate with auto peaks associated with aggregation can be identified. The auto peaks can be referenced to quickly discern the regions of the molecule most perturbed, which would indicate a driver for the crystallization state of the molecule. One can define which functional group types (e.g., region) are most perturbed (positive, intense auto peak) and observe how the different auto peaks begin to have greatest intensity change. These changes in auto peaks in the synchronous plots for the different stages of crystallization can provide information as to the dynamics of the process from amorphous to crystalline state.

公开(公告)号：US11754504B2

公开(公告)日：2023-09-12

申请号：US16648609

申请日：2018-09-19

申请人： Beckman Coulter, Inc.

发明人： Brian Kozicki ,  Creigh Thompson ,  Richard Wolf ,  Laura Holmes ,  David Sorrentino

IPC分类号： G01N21/76 ,  G01N21/27 ,  G01J1/44

CPC分类号： G01N21/76 ,  G01J1/44 ,  G01N21/27 ,  G01N21/272 ,  G01J2001/444 ,  G01N2201/022 ,  G01N2201/12753

摘要： Assays (100) may be performed with a luminometer (400) having a chassis (405) that may include a reaction vessel chamber (610). The luminometer (400) may also include a light passage (640) that intersects the reaction vessel chamber (610). The luminometer (400) may also include a cap (415) that, when in a closed configuration, prevents light emitted by external sources from entering the reaction vessel chamber (610) and from entering the light passage (640). The cap (415) may provide access to the reaction vessel chamber (610) when in an open configuration. The luminometer (400) may also include a calibration light source (460) optically coupled to one end of the light passage (640) and a light detector (630) optically coupled to another end of the light passage (640). The light detector (630) may include a sensing element for receiving light from the light passage (640).

公开(公告)号：US20230194433A1

公开(公告)日：2023-06-22

申请号：US18109980

申请日：2023-02-15

申请人： Beckman Coulter, Inc.

发明人： Richard Wolf ,  David Sorrentino ,  Takayuki Mizutani ,  Glenn Davis

IPC分类号： G01N21/76 ,  G01N21/27 ,  G01J1/44

CPC分类号： G01N21/76 ,  G01N21/27 ,  G01J1/44 ,  G01N21/272 ,  G01N2201/022 ,  G01J2001/444 ,  G01N2201/12753

摘要： A luminometer (400) includes a light detector (630) configured to sense photons (135). The luminometer (400) includes an analog circuit (915a) configured to provide an analog signal (965) based on the photons (135) emitted from assay reactions over a time period and a counter circuit (915b) configured to provide a photon count (970) based on the photons (135) emitted from the assay reactions over the time period. The luminometer (400) includes a luminometer controller (905) configured to, in response to an analog signal value of the analog signal (965) being greater than a predetermined value, determine and report a measurement value of the photons (135) emitted from the assay reactions over the time period based on the analog signal value of the analog signal (965) and a linear function (1010). Optionally, the linear function (1010) is derived from a relationship between the analog signal (965) and the photon count (970).

公开(公告)号：US20190212258A1

公开(公告)日：2019-07-11

申请号：US16332527

申请日：2017-09-15

申请人： C Technologies

发明人： Craig Harrison ,  Ramsey Shanbaky

IPC分类号： G01N21/33 ,  G01N21/03 ,  G01N21/05

CPC分类号： G01N21/33 ,  B01D15/20 ,  B01D35/02 ,  B01D57/02 ,  B01D61/20 ,  B01D65/10 ,  G01N21/0303 ,  G01N21/0317 ,  G01N21/05 ,  G01N21/272 ,  G01N27/44721 ,  G01N30/466 ,  G01N30/50 ,  G01N30/74 ,  G01N30/88 ,  G01N2021/1748 ,  G01N2030/8886

摘要： The present invention relates to methods for determining the change in concentration of a substance in solution over time by continuously monitoring in real time. In particular, the present invention relates to methods for continuously monitoring the concentration of compounds during the manufacturing process of biomolecules.

公开(公告)号：US20180238788A1

公开(公告)日：2018-08-23

申请号：US15897895

申请日：2018-02-15

申请人： Commissariat A L'energie Atomique Et Aux Energies Alternatives

发明人： Cedric ALLIER ,  Melissa Baque ,  Thomas Bordy ,  Anne-Gaelle Bourdat ,  Daniel Vellou

IPC分类号： G01N15/02 ,  G01N15/14 ,  G01N33/53

CPC分类号： G01N15/0205 ,  C12Q1/6825 ,  C12Q1/6851 ,  G01N15/1468 ,  G01N21/272 ,  G01N21/4788 ,  G01N21/75 ,  G01N21/82 ,  G01N33/5304 ,  G01N2015/0057 ,  G01N2015/0065 ,  G01N2015/0092 ,  G01N2015/0222 ,  G01N2015/145 ,  G01N2021/755 ,  G03H2001/0447 ,  C12Q2525/301 ,  C12Q2563/137 ,  C12Q2565/301 ,  C12Q2565/607

摘要： The invention relates to a method for tracking the amplification of a sequence of nucleotides in a sample (10). The sample is placed between a light source (12) and an image sensor (16). Under the effect of amplification reagents, mixed with the sample, a nucleotide sequence, called the target sequence, is replicated iteratively, amplifying the target sequence. The method includes the acquisition of an image representative of the formation of a precipitate in the sample under the effect of the amplification, on the basis of which an image of interest is formed. The application of a statistical indicator to the image of interest allows an indicator of the amplification of the target sequence to be determined.

公开(公告)号：US09990464B1

公开(公告)日：2018-06-05

申请号：US14049863

申请日：2013-10-09

申请人： SENSIQ TECHNOLOGIES, INC.

发明人： John Gerard Quinn

IPC分类号： C12M1/34 ,  G06F19/12 ,  G01N33/557 ,  G01N35/08 ,  G01N33/53 ,  G01N21/55 ,  G01N21/552 ,  G01N35/10 ,  G01N21/05

CPC分类号： G06F19/12 ,  B01L2300/0636 ,  G01N21/272 ,  G01N21/55 ,  G01N21/553 ,  G01N33/53 ,  G01N35/08 ,  G01N35/085 ,  G01N35/1097 ,  G01N2021/058 ,  G01N2035/00702

摘要： Dispersion injection methods for determining biomolecular interaction parameters in label-free biosensing systems are provided. The methods generally relate to the use of a single analyte injection that generates a smoothly-varying concentration gradient via dispersion en route to a sensing region possessing an immobilized binding partner. The present method incorporates the use of an internal standard which provides a reference as to the dispersion conditions present which can then be used to calculate an effective diffusion coefficient for the analyte of interest based on a universal calibration function. The effective diffusion coefficient can then be incorporated into the appropriate dispersion model to provide a calibrated dispersion model. The calibrated dispersion model can then be incorporated into the desired interaction model to provide a reliable representation of the analyte concentration at the sensing region at any time during the injection. The use of the internal standard and universal calibration function permit use of a wide range of injection conditions which may not otherwise be consistent with a particular dispersion model. Thus, the present methods allow for higher flow rates and lower sample volumes thereby increasing assay speed and decreasing sample consumption.