Abstract:
The present invention relates generally to methods of using nalfurafine for treating and/or preventing demyelinating disease in a subject, and in particular for treating and/or preventing multiple sclerosis (MS). Also disclosed is nalfurafine for use in treating and/or preventing MS as well as pharmaceutical compositions and unit dosage forms comprising nalfurafine for use for treating and/or preventing demyelinating disease in a subject, and in particular for treating and/or preventing MS.
Abstract:
A cryogenic cooling system for a superconducting device includes a thermally insulated cryostat for containing liquid nitrogen in which the superconducting device immersed, a cryocooler for cooling the superconducting device, and a cryogenic fluid circuit for thermally coupling the superconducting device to a cold head of the cryocooler. The cryogenic fluid circuit includes a heat exchanger in the cryostat for immersion in the liquid nitrogen, a condenser thermally coupled to the cold head, a liquid delivery tube coupling the condenser to the heat exchanger for conveying cryogenic liquid condensed in the condenser to the heat exchanger, and a gas return tube coupling the heat exchanger to the condenser for returning cryogen vapor evaporated from the cryogenic liquid in the heat exchanger to the condenser.
Abstract:
The invention relates to a combination of a TLR-9 agonist and a conjugate of Formula (I) or pharmaceutically acceptable salt thereof. (Formula (I))
Abstract:
A thermally insulated vessel contains a thermal insulation barrier defining an upper compartment above the barrier and a lower compartment below the barrier. The compartments are interconnected by a passage to allow pressure equalization. High temperature superconductor is mounted within the lower compartment for immersion in the liquid cryogen. A cryogenic refrigerator has a cold head thermally coupled to the high temperature superconductor for maintaining the high temperature superconductor below a superconductive transition temperature. A temperature controller maintains a temperature of the liquid cryogen in the upper compartment at a temperature of at least a boiling point of the liquid cryogen at atmospheric pressure when the lower compartment and at least a portion of the upper compartment are filled with the liquid cryogen.
Abstract:
The invention relates to brartemicin analogues of Formula (IV) and their uses. These compounds are potent Mincle agonists and Th1-stimulating vaccine adjuvants.
Abstract:
A cryogenic system includes a housing of a cryogenic chamber, a cold source in the cryogenic chamber, and a circulation loop for circulating cryogenic fluid between the cold source and a component to be cooled in the cryogenic chamber. The component has an elongated thermally conductive structure extending to a warmer environment. For adjustable cooling of the structure, an incoming stream of the cryogenic fluid is directed along a length of the structure extending from the component, and this stream is split into a first outgoing stream at a first location from the component and a second outgoing stream at a second location further from the component, and an adjustable valve adjusts the fraction of the incoming stream that becomes the second outgoing stream.
Abstract:
A cryogenic system includes a housing of a cryogenic chamber, a cold source in the cryogenic chamber, and a gas circulation loop for circulating cryogenic gas between the cold source and material to be cooled in the cryogenic chamber. The circulation loop includes a gas pump, and a counter-flow heat exchanger connecting the gas pump to the cold source for cooling an in-flow of the cryogenic gas from the gas pump to the cold source with an out-flow of the cryogenic gas from the material to be cooled to the gas pump. In a preferred construction, the heat exchanger includes an outer tube and an inner tube nested within the outer tube, and a pair of three-port connector fittings attached to respective ends of the tubes.