公开(公告)号：US08075309B2

公开(公告)日：2011-12-13

申请号：US11982301

申请日：2007-10-31

Applicant: Chunhua Li ,  Wenda C. Carlyle ,  Philippe De Smedt ,  Amir Abolfathi ,  Eric E. Kuo ,  Robert E. Tricca ,  Jennifer C. Chen ,  Benjamin M. Wu

Inventor： Chunhua Li ,  Wenda C. Carlyle ,  Philippe De Smedt ,  Amir Abolfathi ,  Eric E. Kuo ,  Robert E. Tricca ,  Jennifer C. Chen ,  Benjamin M. Wu

IPC: A61C3/00 ,  A61C17/00 ,  A61C17/02 ,  A61C5/04 ,  A61G17/02 ,  A61G5/02

CPC classification number: A61C19/063 ,  A61C7/00 ,  A61C7/008 ,  A61C7/08 ,  A61C8/00

Abstract: Systems and methods are disclosed for intra-oral delivery of drugs. One method embodiment includes providing a dental device with one or more reservoirs, supplying at least one of the reservoirs with the one or more substances, and fluidly releasing the one or more substances from at least one reservoir into an oral structure at different preselected doses at different predetermined time periods and in a predetermined sequence.

Abstract translation: 公开了用于口服内递送药物的系统和方法。 一种方法实施方案包括向牙科设备提供一个或多个储存器，向至少一个储存器提供一种或多种物质，并且以不同的预选剂量将一种或多种物质从至少一个储存器流体释放到口腔结构中 不同的预定时间段和预定的顺序。

公开(公告)号：US09636309B2

公开(公告)日：2017-05-02

申请号：US13229473

申请日：2011-09-09

Applicant: James B. McClain ,  Charles Douglas Taylor ,  Wenda C. Carlyle

Inventor： James B. McClain ,  Charles Douglas Taylor ,  Wenda C. Carlyle

IPC: A61K47/34 ,  A61K9/70 ,  A61K9/00

CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K9/0021 ,  A61K9/7007 ,  A61K31/436

Abstract: Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile.

公开(公告)号：US08911468B2

公开(公告)日：2014-12-16

申请号：US13362492

申请日：2012-01-31

Applicant: Matthew F. Ogle ,  Edward J. Anderson ,  Todd D. Reil ,  Wenda C. Carlyle

Inventor： Matthew F. Ogle ,  Edward J. Anderson ,  Todd D. Reil ,  Wenda C. Carlyle

IPC: A61M29/02 ,  A61B17/12 ,  A61B17/00 ,  A61B17/22

CPC classification number: A61B17/12109 ,  A61B17/00491 ,  A61B17/12036 ,  A61B17/12181 ,  A61B17/12195 ,  A61B2017/22067

Abstract: The methods and devices disclosed herein pertain to the percutaneous treatment of various forms of aortic dissection by at least partially filling the false lumen of the aortic dissection with a stabilization agent percutaneously and steps to decrease the size of the false lumen using the devices. Fluid maybe aspirated from the false lumen to decrease the volume of the false lumen. And the entrance opening between the true lumen and the false lumen may be sealed with a sealing agent such as a biocompatible adhesive. The medical devices disclosed herein generally comprise an extendable sealing element that is used in conjunction with a catheter to expand the true lumen while reducing the size of the false lumen. The device has the ability to aspirate and/or deliver fluid containing the stabilization agent into the false lumen.

Abstract translation: 本文公开的方法和装置涉及通过至少部分地用稳定剂经皮肤填充主动脉夹层的假腔以及使用该装置减少假腔的尺寸的步骤来经皮治疗各种形式的主动脉夹层。 流体可能从假腔吸出，以减少假腔的体积。 并且真空腔和假腔之间的入口可以用诸如生物相容性粘合剂的密封剂密封。 本文公开的医疗装置通常包括可延伸的密封元件，其与导管结合使用以在减少假腔的尺寸的同时扩张真腔。 该装置具有将含有稳定剂的流体吸入和/或输送到假腔中的能力。

公开(公告)号：US20120064124A1

公开(公告)日：2012-03-15

申请号：US13229473

申请日：2011-09-09

Applicant: James B. McClain ,  Charles Douglas Taylor ,  Wenda C. Carlyle

Inventor： James B. McClain ,  Charles Douglas Taylor ,  Wenda C. Carlyle

IPC: A61K9/00 ,  A61P27/16 ,  A61P19/02 ,  A61P15/00 ,  A61P13/00 ,  A61M5/32 ,  A61P37/08 ,  A61P27/02 ,  A61P31/00 ,  A61P37/06 ,  A61M5/00 ,  A61M5/30 ,  A61K39/00 ,  A61P35/00

CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K9/0021 ,  A61K9/7007 ,  A61K31/436

Abstract: Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile.

Abstract translation: 提供了包含至少一种聚合物和至少一种活性剂的药物递送组合物; 其中所述活性剂以结晶形式存在于所述组合物的外表面的至少一个区域上，并且其中调节活性剂表面含量以提供选定的活性剂释放曲线。