公开(公告)号：US20070098594A1

公开(公告)日：2007-05-03

申请号：US11267962

申请日：2005-11-03

申请人： Christopher Elkin ,  William Hoover ,  Ronald Kurnik

发明人： Christopher Elkin ,  William Hoover ,  Ronald Kurnik

IPC分类号： G01N35/00

CPC分类号： G01N21/6452 ,  G01N21/6428 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6441

摘要： Analytical multi-spectral optical detection systems and methods. A light source provides one or multiple lines (e.g., discrete wavelengths) of high spectral purity excitation light that is optically coupled to a sample via delivery fiber optic cables. Emission light is collected and provided to an emission detector, such as a diffraction gradient spectrophotometer emission detector, using collection fiber optic cables bundled with the delivery fiber optic cables in a probe interface positioned proximal a sample holder. The probe interface may be scanned over one or more samples, or one or more samples may be scanned proximal a fixed interface probe. Multiple excitation wavelengths allows for simultaneous excitation and detection of multiple fluorescent dyes in the visible spectrum. This increases sample throughput and reduces signal variations associated with signal acquisition at different times. The optical system provides several advantages over other systems including higher sensitivity, improved compatibility with fluorescent dyes, better signal discrimination, increased system reliability and reduced manufacturing and service costs.

摘要翻译： 分析多光谱光学检测系统及方法。 光源提供通过输送光纤光学耦合到样品的高光谱纯度激发光的一条或多条线（例如离散波长）。 将发射光收集并提供给发射检测器，例如衍射梯度分光光度计发射检测器，使用在传送光纤电缆捆绑的收集光缆在位于样品架附近的探针接口中。 可以在一个或多个样本上扫描探针接口，或者可以在固定接口探针附近扫描一个或多个样品。 多个激发波长允许在可见光谱中同时激发和检测多种荧光染料。 这增加了采样吞吐量，并减少了在不同时间与信号采集相关的信号变化。 该光学系统提供了优于其他系统的几个优点，包括更高的灵敏度，改善与荧光染料的相容性，更好的信号鉴别，增加的系统可靠性以及降低的制造和服务成本。

公开(公告)号：USD338916S

公开(公告)日：1993-08-31

申请号：US806130

申请日：1991-12-12

申请人： William Hoover ,  Richard Schneider ,  Ronald Greenfield

设计人： William Hoover ,  Richard Schneider ,  Ronald Greenfield