公开(公告)号：US09585923B2

公开(公告)日：2017-03-07

申请号：US12992810

申请日：2009-05-14

申请人： Dae Hee Lee ,  Eun Kyong Lee ,  Eun Mi So ,  Young Woo Jin

发明人： Dae Hee Lee ,  Eun Kyong Lee ,  Eun Mi So ,  Young Woo Jin

IPC分类号： A61K36/00 ,  A61K36/13 ,  A61K8/97 ,  A61Q19/02 ,  A61Q19/08

CPC分类号： A61K36/13 ,  A61K8/97 ,  A61Q19/02 ,  A61Q19/08

摘要： The present invention relates to an antioxidant, anti-inflammatory or anti-aging composition containing any one or more of a Taxus cambium- or procambium-derived cell line, an extract thereof, a lysate thereof and a culture medium thereof. The composition according to the present invention has minimized side effects compared to existing antioxidants and anti-inflammatory agents, is involved in intracellular metabolism to reduce intracellular reactive oxygen species, and reduces and induces aging-related signals. Thus, the composition of the preset invention is useful for preventing and delaying aging. In addition, the composition of the present invention has the effect of inhibiting melanogenesis, and thus is useful as a whitening cosmetic composition.

摘要翻译： 本发明涉及一种抗氧化剂，抗炎或抗衰老组合物，其中含有一种或多种紫杉形成层或原生动物来源的细胞系，其提取物，其裂解物及其培养基。 根据本发明的组合物与现有抗氧化剂和抗炎剂相比具有最小化的副作用，涉及细胞内代谢以减少细胞内活性氧，并减少并诱导老化相关信号。 因此，本发明的组合物可用于防止和延缓老化。 此外，本发明的组合物具有抑制黑素生成的作用，因此可用作美白化妆品组合物。

公开(公告)号：US08329471B2

公开(公告)日：2012-12-11

申请号：US12889126

申请日：2010-09-23

申请人： Young Woo Jin ,  Eun Kyong Lee

发明人： Young Woo Jin ,  Eun Kyong Lee

IPC分类号： C12N5/00 ,  C12N5/02

CPC分类号： C12N5/04

摘要： This invention is a method of minimizing the variation of cell growth and production through homogeneous cell line development. To be more specific, it is the method of isolating and proliferating single cell clone from cambium or procambium to promote the stability of the plant-derived biologically active substances production by solving the problems of decrease in cell growth and the productivity during the long term culture.

摘要翻译： 本发明是通过均质细胞系发育来最小化细胞生长和产生变化的方法。 更具体地说，它是从形成层或原生质体中分离和增殖单细胞克隆的方法，通过解决长期培养中细胞生长减少和生产力的问题来促进植物来源的生物活性物质生产的稳定性 。

公开(公告)号：US20110229443A1

公开(公告)日：2011-09-22

申请号：US13127750

申请日：2009-11-06

申请人： Young Woo Jin ,  Eun Kyong Lee

发明人： Young Woo Jin ,  Eun Kyong Lee

IPC分类号： A61K36/258 ,  C12N5/04 ,  A61P35/00 ,  A61P35/02

CPC分类号： A61K36/258 ,  A01H4/005 ,  A23L33/105 ,  A23V2002/00 ,  C12N5/04 ,  A23V2200/308 ,  A23V2250/21

摘要： The present invention relates to a composition for preventing or treating cancer, which contains, as an active ingredient, a Panax ginseng cambium-derived cell line including wild ginseng or ginseng; a lysate thereof; an extract thereof; or a culture medium thereof.The cell line according to the present invention, a lysate thereof, an extract thereof and a culture medium thereof are derived from a natural and have minimized side effects compared to the conventional therapeutic drugs, and thus are safe for the human body. Also, they are involved directly in the growth of cancer to induce cancer cell death effectively, and show anticancer activity of inhibiting or reducing the formation of tumor or the growth of tumor, Accordingly, the cell line, the lysate thereof, the extract thereof and the culture medium thereof are useful for the prevention, treatment and alleviation of cancer.

摘要翻译： 本发明涉及一种预防或治疗癌症的组合物，其含有人参或人参的人参形成层细胞系作为活性成分， 其裂解物; 其提取物; 或其培养基。 根据本发明的细胞系，其裂解物，其提取物和培养基来自天然，并且与常规治疗药物相比具有最小的副作用，因此对于人体是安全的。 此外，它们直接参与癌细胞的生长，有效地诱导癌细胞死亡，并且显示抑制或减少肿瘤形成或肿瘤生长的抗癌活性。因此，细胞系，其裂解物，其提取物和 其培养基可用于预防，治疗和缓解癌症。

公开(公告)号：US08017397B2

公开(公告)日：2011-09-13

申请号：US12063929

申请日：2006-04-25

申请人： Young Woo Jin ,  Eun Kyong Lee

发明人： Young Woo Jin ,  Eun Kyong Lee

IPC分类号： C12N5/00 ,  C12N5/02

CPC分类号： C12N5/04

摘要： This invention is a method of minimizing the variation of cell growth and production through homogeneous cell line development. To be more specific, it is the method of isolating and proliferating single cell clone from the cambium to promote the stability of the plant-derived biologically active substances production by solving the problems of decrease in cell growth and the productivity during the long term culture.

摘要翻译： 本发明是通过均质细胞系发育来最小化细胞生长和产生变化的方法。 更具体地说，它是从形成层分离和增殖单细胞克隆的方法，通过解决长期培养中细胞生长减少和生产力的问题来促进植物来源的生物活性物质生产的稳定性。

公开(公告)号：US20110217273A1

公开(公告)日：2011-09-08

申请号：US13121930

申请日：2009-09-30

申请人： Sun Mi Hong ,  Eun Kyong Lee ,  Young Woo Jin

发明人： Sun Mi Hong ,  Eun Kyong Lee ,  Young Woo Jin

IPC分类号： A61K36/00 ,  A61K36/258 ,  A61P31/12

CPC分类号： A61K36/258 ,  A01H4/005 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  C12N5/04 ,  A23V2200/30 ,  A23V2250/2124

摘要： The present invention relates to a composition for preventing or treating acquired immunodeficiency syndrome (AIDS), comprising one or more of the following: a homogenous cell line, and a lysate, an extract and a culture thereof as an active ingredient. The homogenous cell line, the lysate, the extract and the culture thereof, which are derived from a natural product, minimize adverse side effects of prior therapeutic agents and safe for the human body. Further, they effectively increase the count of T cells such as CD4+ T cells and decrease the number of HIVs, thereby preventing opportunistic infection, dysneuria, and neoplasia caused by immune incompetence, and ultimately the risk of death. Therefore, they are useful in preventing and treating AIDS, and relieving symptoms of AIDS.

摘要翻译： 本发明涉及用于预防或治疗获得性免疫缺陷综合征（AIDS）的组合物，其包含以下一种或多种：均质细胞系，其裂解物，提取物和培养物作为活性成分。 衍生自天然产物的均质细胞系，裂解物，提取物和培养物使得现有治疗剂的不良副作用最小化并对人体安全。 此外，它们有效地增加了T细胞如CD4 + T细胞的数量，并减少了HIV的数量，从而防止机会性感染，排尿障碍和免疫功能不全导致的瘤形成，最终导致死亡风险。 因此，它们有助于预防和治疗艾滋病，缓解艾滋病的症状。

公开(公告)号：US20110117039A1

公开(公告)日：2011-05-19

申请号：US12992810

申请日：2009-05-14

申请人： Dae Hee Lee ,  Eun Kyong Lee ,  Eun Mi So ,  Young Woo Jin

发明人： Dae Hee Lee ,  Eun Kyong Lee ,  Eun Mi So ,  Young Woo Jin

IPC分类号： A61K8/97 ,  A61K36/13 ,  C12N5/04 ,  C12N5/02 ,  A61P29/00 ,  A61P39/06 ,  A61Q19/02 ,  A61Q19/08

CPC分类号： A61K36/13 ,  A61K8/97 ,  A61Q19/02 ,  A61Q19/08

摘要： The present invention relates to an antioxidant, anti-inflammatory or anti-aging composition containing any one or more of a Taxus cambium- or procambium-derived cell line, an extract thereof, a lysate thereof and a culture medium thereof. The composition according to the present invention has minimized side effects compared to existing antioxidants and anti-inflammatory agents, is involved in intracellular metabolism to reduce intracellular reactive oxygen species, and reduces and induces aging-related signals. Thus, the composition of the preset invention is useful for preventing and delaying aging. In addition, the composition of the present invention has the effect of inhibiting melanogenesis, and thus is useful as a whitening cosmetic composition.

摘要翻译： 本发明涉及一种抗氧化剂，抗炎或抗衰老组合物，其中含有一种或多种紫杉形成层或原生动物来源的细胞系，其提取物，其裂解物及其培养基。 根据本发明的组合物与现有抗氧化剂和抗炎剂相比具有最小化的副作用，涉及细胞内代谢以减少细胞内活性氧，并减少并诱导老化相关信号。 因此，本发明的组合物可用于防止和延缓老化。 此外，本发明的组合物具有抑制黑素生成的作用，因此可用作美白化妆品组合物。

公开(公告)号：US20110097310A1

公开(公告)日：2011-04-28

申请号：US12997858

申请日：2009-06-12

申请人： Mi Ok Jang ,  Min Jung Lim ,  Il Seok Oh ,  Dae Hee Lee ,  Eun Kyong Lee ,  Young Woo Jin

发明人： Mi Ok Jang ,  Min Jung Lim ,  Il Seok Oh ,  Dae Hee Lee ,  Eun Kyong Lee ,  Young Woo Jin

IPC分类号： A61K36/25 ,  C12N5/04 ,  A61P17/00

CPC分类号： A61K8/97 ,  A61K2800/522 ,  A61Q19/004 ,  A61Q19/08

摘要： The present invention relates to an anti-aging or antioxidant composition which contains, as an active ingredient, a plant stem cell line derived from the cambium of Panax ginseng, including wild ginseng and ginseng, or an extract thereof, a lysate thereof and a culture thereof. The composition has minimized side effects compared to existing anti-aging agents and antioxidants, and thus is safe for the skin. Also, the composition of the present invention shows an antioxidant effect of inhibiting reactive oxygen species caused by exposure to UV radiation that is the major cause of skin aging, and it can effectively reduce or inhibit aging-related factors. Thus, the composition is useful for the prevention and inhibition of aging.

摘要翻译： 本发明涉及一种抗老化或抗氧化剂组合物，其含有源自人参人参和人参的形成层的植物干细胞系作为活性成分，或其提取物，其裂解物和培养物 其中。 与现有的抗老化剂和抗氧化剂相比，该组合物具有最小的副作用，因此对于皮肤是安全的。 此外，本发明的组合物显示出由于暴露于作为皮肤老化的主要原因的紫外线辐射引起的活性氧的抑制作用，并且可以有效地降低或抑制与老化有关的因素。 因此，该组合物可用于预防和抑制老化。

公开(公告)号：US08247230B2

公开(公告)日：2012-08-21

申请号：US12679269

申请日：2008-09-22

申请人： Mi Ok Jang ,  Eun Kyong Lee ,  Young Woo Jin

发明人： Mi Ok Jang ,  Eun Kyong Lee ,  Young Woo Jin

IPC分类号： C12N5/00 ,  C12N5/02

CPC分类号： C12N5/04

摘要： The present invention relates to a cell line derived from the cambium of an herbaceous plant having a storage root and a method for isolating the same. More specifically, relates to a cambium-derived homogeneous cell line having the ability to divide, which is obtained from the cambium-containing storage tissue of an herbaceous plant having a storage root without a separate dedifferentiation process, and to a method for isolating the same. The cell line derived from the cambium of an herbaceous plant having a storage root has active division ability and is homogeneous. Also, it is stable during culture, because it has not undergone a dedifferentiation process. Thus, through the optimization of proliferation thereof, the cell line can be allowed to proliferate in a large amount within a short time. Accordingly, the cell line derived from the cambium of an herbaceous plant having a storage root makes it possible to produce large amounts of useful plants which are difficult to cultivate outdoor due to various problems associated with the period of cultivation, the selection of cultivation land, cultivation cost and the like.

摘要翻译： 本发明涉及源自具有贮藏根的草本植物的形成层的细胞系及其分离方法。 更具体地说，涉及具有分割能力的形成层的均质细胞系，其是从没有分离去分化方法的具有储存根的草本植物的含有形成层的储存组织获得的，以及其分离方法 。 源自具有储存根的草本植物的形成层的细胞系具有活性分裂能力并且是均匀的。 此外，它在培养期间是稳定的，因为它没有经历去分化过程。 因此，通过优化其增殖，可以在短时间内允许细胞系大量增殖。 因此，从具有储藏根的草本植物的形成层衍生的细胞系，由于与栽培期间，种植面积的选择有关的各种问题，可能产生大量难以栽培的有用植物， 栽培成本等。

公开(公告)号：US20120189660A1

公开(公告)日：2012-07-26

申请号：US13058949

申请日：2009-08-14

申请人： Young Woo Jin ,  Eun Kyong Lee ,  Min Jung Lim

发明人： Young Woo Jin ,  Eun Kyong Lee ,  Min Jung Lim

IPC分类号： A61K36/258 ,  A61P31/14 ,  A61P1/16 ,  A61P37/04 ,  C12N5/04

CPC分类号： A61K36/258 ,  A01H4/005 ,  A23L33/105 ,  A61K36/25 ,  C12N5/04

摘要： The present invention relates to a composition for preventing or treating liver diseases, which contains, as an active ingredient, any one or more of a homogeneous cell line derived from the cambium of Panax ginseng, including wild ginseng or ginseng, a lysate thereof, an extract thereof and a culture medium thereof. The homogeneous cell line according to the present invention, a lysate thereof, an extract thereof and a culture medium thereof have minimized side effects compared to existing agents for treating liver diseases, and thus are safe for the human body. Also, they can increase the levels of s-antibody (HBsAb) and e-antibody (HBeAb) against hepatitis virus and inhibit the proliferation of hepatitis virus, and thus they are useful for the prevention and treatment of liver diseases. In addition, they have the effect of lowering the levels of liver injury, and thus are useful as a functional food for improving liver function.

摘要翻译： 本发明涉及一种预防或治疗肝病的组合物，其含有源自人参的人参或人参的形成层的均质细胞系中的任何一种或多种作为活性成分，其裂解物， 提取物及其培养基。 根据本发明的均相细胞系，其裂解物，其提取物和培养基与现有用于治疗肝脏疾病的药剂相比具有最小的副作用，因此对人体是安全的。 此外，它们可以增加针对肝炎病毒的s-抗体（HBsAb）和e-抗体（HBeAb）的水平，并抑制肝炎病毒的增殖，从而可用于预防和治疗肝脏疾病。 此外，它们具有降低肝损伤水平的作用，因此可用作改善肝功能的功能性食物。

公开(公告)号：US08053238B2

公开(公告)日：2011-11-08

申请号：US12117783

申请日：2008-05-09

申请人： Young Woo Jin ,  Eun Kyong Lee

发明人： Young Woo Jin ,  Eun Kyong Lee

IPC分类号： C12N5/00 ,  C12N5/02

CPC分类号： C12N5/04

摘要： This invention is a method of minimizing the variation of cell growth and production through homogeneous cell line development. To be more specific, it is the method of isolating and proliferating single cell clone from the procambium to promote the stability of the plant-derived biologically active substances production by solving the problems of decrease in cell growth and the productivity during the long term culture.

摘要翻译： 本发明是通过均质细胞系发育来最小化细胞生长和产生变化的方法。 更具体地说，是通过解决长期培养中细胞生长减少和生产力的问题，从原型中分离和增殖单细胞克隆的方法来促进植物来源的生物活性物质生产的稳定性。