公开(公告)号：US08617621B2

公开(公告)日：2013-12-31

申请号：US13202868

申请日：2010-02-23

申请人： Min Jung Lim ,  Young Woo Jin ,  Eun Kyong Lee

发明人： Min Jung Lim ,  Young Woo Jin ,  Eun Kyong Lee

IPC分类号： A61K36/00 ,  A61K36/25 ,  A61K39/00 ,  A61K45/00 ,  C12N5/00

CPC分类号： A61K36/258 ,  A01H4/005 ,  A23L33/105 ,  A23V2002/00 ,  C12N5/04 ,  A23V2200/324 ,  A23V2250/2124

摘要： The present invention relates to a composition for enhancing immunity, comprising one or more of the following: a homogenous cell line, and a lysate, an extract and a culture medium thereof as an active ingredient. The homogenous cell line, the lysate, the extract and the culture thereof according to the present invention, which are derived from a natural product, minimize adverse side effects of prior immune enhancing agents and safe for the human body. Further, they effectively increase the activity of NK cells responsible for innate immunity, as well as increase the proliferation rate of lymph node cells when the cells were re-exposed to an antigen in a specific immune reaction to enhance acquired immunity, and thus are useful as an immune enhancing agent. In particular, the homogenous cell line, the lysate, the extract, and the culture thereof according to the present invention also effectively increase the number of hone marrow cells, thus are not only used as an adjuvant in an immune reaction, but also used in the prevention and treatment of anemia through hematopoiesis.

摘要翻译： 本发明涉及一种用于增强免疫力的组合物，其包含以下一种或多种：均质细胞系，其裂解物，提取物和培养基作为活性成分。 衍生自天然产物的根据本发明的均质细胞系，裂解物，提取物及其培养物使先前的免疫增强剂的不良副作用最小化并且对人体而言是安全的。 此外，它们有效地增加负责先天免疫的NK细胞的活性，并且当细胞在特异性免疫反应中再次暴露于抗原以增强获得性免疫时增加淋巴结细胞的增殖率，因此是有用的 作为免疫增强剂。 特别是根据本发明的均质细胞系，裂解物，提取物及其培养物也有效地增加了骨髓细胞的数量，因此不仅用作免疫反应中的佐剂，而且还用于 通过造血预防和治疗贫血。

公开(公告)号：US20120039918A1

公开(公告)日：2012-02-16

申请号：US13202868

申请日：2010-02-23

申请人： Min Jung Lim ,  Young Woo Jin ,  Eun Kyong Lee

发明人： Min Jung Lim ,  Young Woo Jin ,  Eun Kyong Lee

IPC分类号： A61K36/258 ,  A61P37/04 ,  A61P7/06 ,  C12N5/04

CPC分类号： A61K36/258 ,  A01H4/005 ,  A23L33/105 ,  A23V2002/00 ,  C12N5/04 ,  A23V2200/324 ,  A23V2250/2124

摘要： The present invention relates to a composition for enhancing immunity, comprising one or more of the following: a homogenous cell line, and a lysate, an extract and a culture medium thereof as an active ingredient. The homogenous cell line, the lysate, the extract and the culture thereof according to the present invention, which are derived from a natural product, minimize adverse side effects of prior immune enhancing agents and safe for the human body. Further, they effectively increase the activity of NK cells responsible for innate immunity, as well as increase the proliferation rate of lymph node cells when the cells were re-exposed to an antigen in a specific immune reaction to enhance acquired immunity, and thus are useful as an immune enhancing agent. In particular, the homogenous cell line, the lysate, the extract, and the culture thereof according to the present invention also effectively increase the number of hone marrow cells, thus are not only used as an adjuvant in an immune reaction, but also used in the prevention and treatment of anemia through hematopoiesis.

摘要翻译： 本发明涉及一种用于增强免疫力的组合物，其包含以下一种或多种：均质细胞系，其裂解物，提取物和培养基作为活性成分。 衍生自天然产物的根据本发明的均质细胞系，裂解物，提取物及其培养物使先前的免疫增强剂的不良副作用最小化并且对人体而言是安全的。 此外，它们有效地增加负责先天免疫的NK细胞的活性，并且当细胞在特异性免疫反应中再次暴露于抗原以增强获得性免疫时增加淋巴结细胞的增殖速率，因此是有用的 作为免疫增强剂。 特别是根据本发明的均质细胞系，裂解物，提取物及其培养物也有效地增加了骨髓细胞的数量，因此不仅用作免疫反应中的佐剂，而且还用于 通过造血预防和治疗贫血。

公开(公告)号：US20120189660A1

公开(公告)日：2012-07-26

申请号：US13058949

申请日：2009-08-14

申请人： Young Woo Jin ,  Eun Kyong Lee ,  Min Jung Lim

发明人： Young Woo Jin ,  Eun Kyong Lee ,  Min Jung Lim

IPC分类号： A61K36/258 ,  A61P31/14 ,  A61P1/16 ,  A61P37/04 ,  C12N5/04

CPC分类号： A61K36/258 ,  A01H4/005 ,  A23L33/105 ,  A61K36/25 ,  C12N5/04

摘要： The present invention relates to a composition for preventing or treating liver diseases, which contains, as an active ingredient, any one or more of a homogeneous cell line derived from the cambium of Panax ginseng, including wild ginseng or ginseng, a lysate thereof, an extract thereof and a culture medium thereof. The homogeneous cell line according to the present invention, a lysate thereof, an extract thereof and a culture medium thereof have minimized side effects compared to existing agents for treating liver diseases, and thus are safe for the human body. Also, they can increase the levels of s-antibody (HBsAb) and e-antibody (HBeAb) against hepatitis virus and inhibit the proliferation of hepatitis virus, and thus they are useful for the prevention and treatment of liver diseases. In addition, they have the effect of lowering the levels of liver injury, and thus are useful as a functional food for improving liver function.

摘要翻译： 本发明涉及一种预防或治疗肝病的组合物，其含有源自人参的人参或人参的形成层的均质细胞系中的任何一种或多种作为活性成分，其裂解物， 提取物及其培养基。 根据本发明的均相细胞系，其裂解物，其提取物和培养基与现有用于治疗肝脏疾病的药剂相比具有最小的副作用，因此对人体是安全的。 此外，它们可以增加针对肝炎病毒的s-抗体（HBsAb）和e-抗体（HBeAb）的水平，并抑制肝炎病毒的增殖，从而可用于预防和治疗肝脏疾病。 此外，它们具有降低肝损伤水平的作用，因此可用作改善肝功能的功能性食物。

公开(公告)号：US20100272692A1

公开(公告)日：2010-10-28

申请号：US12682574

申请日：2008-10-10

申请人： Joong Hyun Park ,  Min Jung Lim ,  Il Seok Oh ,  Dae Hee Lee ,  Jung Chang Lee ,  Eun Kyong Lee ,  Young Woo Jin

发明人： Joong Hyun Park ,  Min Jung Lim ,  Il Seok Oh ,  Dae Hee Lee ,  Jung Chang Lee ,  Eun Kyong Lee ,  Young Woo Jin

IPC分类号： A61K35/00 ,  A61K36/13 ,  A61P35/00

CPC分类号： A61K36/13

摘要： The present invention relates to a composition for preventing or treating cancer, which contains, as an active ingredient, a Taxus cambium- or procambium-derived cell line; a lysate thereof; an extract thereof; or a culture medium thereof. The cell line, the lysate, the extract, and the culture medium has minimized side effects compared to the conventional therapeutic drugs, is safe to the human body, is involved directly in the growth of cancer to induce cancer cell death, and shows anticancer activity of inhibiting angiogenesis occurring in carcinogenesis. Accordingly, the cell line, the lysate, the extract and the culture medium is useful for the prevention, treatment and alleviation of cancer.

摘要翻译： 本发明涉及一种用于预防或治疗癌症的组合物，其含有作为有效成分的红豆杉形成层或原生动物来源的细胞系; 其裂解物; 其提取物; 或其培养基。 细胞系，裂解物，提取物和培养基与常规治疗药物相比具有最小化的副作用，对人体是安全的，直接参与癌症的生长以诱导癌细胞死亡，并且显示抗癌活性 抑制致癌作用中发生的血管生成。 因此，细胞系，裂解物，提取物和培养基可用于预防，治疗和缓解癌症。

公开(公告)号：US5834437A

公开(公告)日：1998-11-10

申请号：US566130

申请日：1995-12-01

申请人： Sang-Sup Jew ,  Hee-Doo Kim ,  Young-Hoon Jung ,  Eun-Hee Park ,  Sung-Ki Seo ,  Tae-Gyu Nam ,  Duc-Ky Hahn ,  Jae-Ho Park ,  Pil-Jong Sim ,  Min-Jung Lim ,  Kyung-Haw Lim

发明人： Sang-Sup Jew ,  Hee-Doo Kim ,  Young-Hoon Jung ,  Eun-Hee Park ,  Sung-Ki Seo ,  Tae-Gyu Nam ,  Duc-Ky Hahn ,  Jae-Ho Park ,  Pil-Jong Sim ,  Min-Jung Lim ,  Kyung-Haw Lim

IPC分类号： C07D303/38 ,  A61K31/045 ,  A61K31/19 ,  A61K31/215 ,  A61K31/335 ,  A61K31/336 ,  A61K31/695 ,  A61K36/23 ,  A61P17/00 ,  C07C33/14 ,  C07C61/29 ,  C07C62/30 ,  C07C62/32 ,  C07C62/38 ,  C07C69/00 ,  C07C69/753 ,  C07C309/66 ,  C07C323/61 ,  C07D309/12 ,  C07J63/00 ,  C07J71/00 ,  A61K31/70 ,  C07H15/24

CPC分类号： C07C69/00 ,  C07C309/66 ,  C07C323/61 ,  C07C33/14 ,  C07C62/32 ,  C07C62/38 ,  C07J63/008 ,  C07J71/0005 ,  C07J71/001 ,  C07C2103/00

摘要： The object of the present invention is to provide asiatic acid derivatives, its pharmaceutically acceptable salts or esters. Asiatic acid, its trisaccharide asiaticoside and mddecassic acid, extracted from Centella asiatica have been used for a long time in the management of skin scars and chronic ulcers. In this invention, asiatic acid derivatives synthesized from asiatic acid show excellent wound-healing properties.

摘要翻译： 本发明的目的是提供积雪草酸衍生物，其药学上可接受的盐或酯。 从积雪草积雪提取的积雪草，三糖积雪草苷和十六烷酸已经被用于治疗皮肤瘢痕和慢性溃疡的很长时间。 在本发明中，由积雪草酸合成的积雪草酸衍生物具有良好的伤口愈合性。

公开(公告)号：US20110097310A1

公开(公告)日：2011-04-28

申请号：US12997858

申请日：2009-06-12

申请人： Mi Ok Jang ,  Min Jung Lim ,  Il Seok Oh ,  Dae Hee Lee ,  Eun Kyong Lee ,  Young Woo Jin

发明人： Mi Ok Jang ,  Min Jung Lim ,  Il Seok Oh ,  Dae Hee Lee ,  Eun Kyong Lee ,  Young Woo Jin

IPC分类号： A61K36/25 ,  C12N5/04 ,  A61P17/00

CPC分类号： A61K8/97 ,  A61K2800/522 ,  A61Q19/004 ,  A61Q19/08

摘要： The present invention relates to an anti-aging or antioxidant composition which contains, as an active ingredient, a plant stem cell line derived from the cambium of Panax ginseng, including wild ginseng and ginseng, or an extract thereof, a lysate thereof and a culture thereof. The composition has minimized side effects compared to existing anti-aging agents and antioxidants, and thus is safe for the skin. Also, the composition of the present invention shows an antioxidant effect of inhibiting reactive oxygen species caused by exposure to UV radiation that is the major cause of skin aging, and it can effectively reduce or inhibit aging-related factors. Thus, the composition is useful for the prevention and inhibition of aging.

摘要翻译： 本发明涉及一种抗老化或抗氧化剂组合物，其含有源自人参人参和人参的形成层的植物干细胞系作为活性成分，或其提取物，其裂解物和培养物 其中。 与现有的抗老化剂和抗氧化剂相比，该组合物具有最小的副作用，因此对于皮肤是安全的。 此外，本发明的组合物显示出由于暴露于作为皮肤老化的主要原因的紫外线辐射引起的活性氧的抑制作用，并且可以有效地降低或抑制与老化有关的因素。 因此，该组合物可用于预防和抑制老化。