公开(公告)号：US08658657B2

公开(公告)日：2014-02-25

申请号：US13123761

申请日：2009-10-22

申请人： Shuji Yonezawa ,  Yuuji Kooriyama ,  Gaku Sakaguchi

发明人： Shuji Yonezawa ,  Yuuji Kooriyama ,  Gaku Sakaguchi

IPC分类号： A01N43/54 ,  A61K31/505 ,  C07D239/02

摘要： The present invention provides a compound which has an effect of inhibiting amyloid-β production and is useful as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-β proteins. The present invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein A is optionally substituted carbocyclic diyl or optionally substituted heterocyclic diyl; B is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is a group such as optionally substituted lower alkyl; R2 is a group such as hydrogen; and R3a and R3b are each independently a group such as hydrogen, provided that the following compound is excluded.

公开(公告)号：US08507479B2

公开(公告)日：2013-08-13

申请号：US13417786

申请日：2012-03-12

申请人： Yuusuki Tamura ,  Shinji Suzuki ,  Yukio Tada ,  Chiaki Fujikoshi ,  Sae Matsumoto ,  Yuuji Kooriyama

发明人： Yuusuki Tamura ,  Shinji Suzuki ,  Yukio Tada ,  Chiaki Fujikoshi ,  Sae Matsumoto ,  Yuuji Kooriyama

IPC分类号： C07D417/12 ,  C07D417/14 ,  A61K31/497 ,  A61K31/54

摘要： This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R3a, R3b, R3c and R3d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid β protein.

公开(公告)号：US20120258961A1

公开(公告)日：2012-10-11

申请号：US13518285

申请日：2010-12-22

申请人： Shinji Suzuki ,  Yuuji Kooriyama

发明人： Shinji Suzuki ,  Yuuji Kooriyama

IPC分类号： A61K31/54 ,  C12N9/99 ,  A61K31/541 ,  A61P25/28 ,  A61K31/536 ,  C07D413/12 ,  A61K31/5415 ,  C07D279/06 ,  C07D417/12 ,  C07D265/20

CPC分类号： C07D265/20 ,  A61K31/536 ,  A61K31/54 ,  A61K31/541 ,  A61K31/5415 ,  C07D279/06 ,  C07D279/16 ,  C07D413/12 ,  C07D417/12

摘要： The present invention provide a medicament for treating the diseases induced by production, secretion or deposition of amyloid-β proteins, for example, a compound of the following formula (I) wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, ring A, Y and the dotted line are defined in the specification, its pharmaceutically acceptable salt or a solvate thereof.

摘要翻译： 本发明提供了用于治疗由淀粉样蛋白的生产，分泌或沉积诱导的疾病的药物。 蛋白质，例如下列通式（I）的化合物，其中R1，R2a，R2b，R3a，R3b，R4a，R4b，环A，Y和虚线在本说明书中定义，其药学上可接受的盐或溶剂合物 其中。

公开(公告)号：US20120172355A1

公开(公告)日：2012-07-05

申请号：US13417786

申请日：2012-03-12

申请人： Yuusuke TAMURA ,  Shinji SUZUKI ,  Yukio TADA ,  Shuji YONEZAWA ,  Chiaki FUJIKOSHI ,  Sae MATSUMOTO ,  Yuuji KOORIYAMA ,  Tatsuhiko UENO

发明人： Yuusuke TAMURA ,  Shinji SUZUKI ,  Yukio TADA ,  Shuji YONEZAWA ,  Chiaki FUJIKOSHI ,  Sae MATSUMOTO ,  Yuuji KOORIYAMA ,  Tatsuhiko UENO

IPC分类号： A61K31/541 ,  C07D417/12 ,  A61K31/54 ,  C07D279/06

CPC分类号： C07C215/20 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/2018 ,  C07D279/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04

摘要： This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R3a, R3b, R3c and R3d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid β protein.

摘要翻译： 本发明提供式（I）的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; R1是任选取代的低级烷基，任选取代的低级烯基，任选取代的低级炔基; R2a和R2b各自独立地为氢，任选取代的低级烷基或任选取代的酰基; R3a，R3b，R3c和R3d各自独立地为氢，卤素，羟基或任选取代的低级烷基等; 其药学上可接受的盐或溶剂合物，其可用于治疗由淀粉样蛋白的生产，分泌和/或沉积诱导的疾病; 蛋白。

公开(公告)号：US20100075957A1

公开(公告)日：2010-03-25

申请号：US12596796

申请日：2008-04-23

申请人： Yuusuke Tamura ,  Shinji Suzuki ,  Yukio Tada ,  Shuji Yonezawa ,  Chiaki Fujikoshi ,  Sae Matsumoto ,  Yuuji Kooriyama ,  Tatsuhiko Ueno

发明人： Yuusuke Tamura ,  Shinji Suzuki ,  Yukio Tada ,  Shuji Yonezawa ,  Chiaki Fujikoshi ,  Sae Matsumoto ,  Yuuji Kooriyama ,  Tatsuhiko Ueno

IPC分类号： A61K31/541 ,  C07D417/12 ,  A61P25/28

CPC分类号： C07C215/20 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/2018 ,  C07D279/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04

摘要： This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R3 a, R3 b, R3 c and R3 d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid β protein.

摘要翻译： 本发明提供式（I）的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; R1是任选取代的低级烷基，任选取代的低级烯基，任选取代的低级炔基; R2a和R2b各自独立地为氢，任选取代的低级烷基或任选取代的酰基; R3a，R3b，R3c和R3d各自独立地为氢，卤素，羟基或任选取代的低级烷基等; 其药学上可接受的盐或溶剂合物，其可用于治疗由淀粉样蛋白的生产，分泌和/或沉积诱导的疾病; 蛋白。