公开(公告)号：US08541408B2

公开(公告)日：2013-09-24

申请号：US13417786

申请日：2012-03-12

申请人： Yuusuki Tamura ,  Shinji Suzuki ,  Yukio Tada ,  Chiaki Fujikoshi ,  Sae Matsumoto ,  Yuuji Kooriyama

发明人： Yuusuki Tamura ,  Shinji Suzuki ,  Yukio Tada ,  Chiaki Fujikoshi ,  Sae Matsumoto ,  Yuuji Kooriyama

IPC分类号： C07D417/12 ,  C07D417/14 ,  A61K31/497 ,  A61K31/54

CPC分类号： C07C215/20 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/2018 ,  C07D279/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04

摘要： This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R3a, R3b, R3c and R3d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid β protein.

摘要翻译： 本发明提供式（I）的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; R1是任选取代的低级烷基，任选取代的低级烯基，任选取代的低级炔基; R2a和R2b各自独立地为氢，任选取代的低级烷基或任选取代的酰基; R3a，R3b，R3c和R3d各自独立地为氢，卤素，羟基或任选取代的低级烷基等; 其药学上可接受的盐或溶剂合物，其可用于治疗由淀粉样β蛋白的产生，分泌和/或沉积诱导的疾病。

公开(公告)号：US08507479B2

公开(公告)日：2013-08-13

申请号：US13417786

申请日：2012-03-12

申请人： Yuusuki Tamura ,  Shinji Suzuki ,  Yukio Tada ,  Chiaki Fujikoshi ,  Sae Matsumoto ,  Yuuji Kooriyama

发明人： Yuusuki Tamura ,  Shinji Suzuki ,  Yukio Tada ,  Chiaki Fujikoshi ,  Sae Matsumoto ,  Yuuji Kooriyama

IPC分类号： C07D417/12 ,  C07D417/14 ,  A61K31/497 ,  A61K31/54

摘要： This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R3a, R3b, R3c and R3d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid β protein.

公开(公告)号：US08168630B2

公开(公告)日：2012-05-01

申请号：US12596796

申请日：2008-04-23

申请人： Yuusuke Tamura ,  Shinji Suzuki ,  Yukio Tada ,  Shuji Yonezawa ,  Chiaki Fujikoshi ,  Sae Matsumoto ,  Yuuji Kooriyama ,  Tatsuhiko Ueno

发明人： Yuusuke Tamura ,  Shinji Suzuki ,  Yukio Tada ,  Shuji Yonezawa ,  Chiaki Fujikoshi ,  Sae Matsumoto ,  Yuuji Kooriyama ,  Tatsuhiko Ueno

IPC分类号： C07D417/12 ,  C07D417/14 ,  A61K31/497 ,  A61K31/54

CPC分类号： C07C215/20 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/2018 ,  C07D279/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04

摘要： This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R3a, R3b, R3c and R3d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid β protein.

摘要翻译： 本发明提供式（I）的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; R1是任选取代的低级烷基，任选取代的低级烯基，任选取代的低级炔基; R2a和R2b各自独立地为氢，任选取代的低级烷基或任选取代的酰基; R3a，R3b，R3c和R3d各自独立地为氢，卤素，羟基或任选取代的低级烷基等; 其药学上可接受的盐或溶剂合物，其可用于治疗由淀粉样蛋白的生产，分泌和/或沉积诱导的疾病; 蛋白。

公开(公告)号：US20100075957A1

公开(公告)日：2010-03-25

申请号：US12596796

申请日：2008-04-23

申请人： Yuusuke Tamura ,  Shinji Suzuki ,  Yukio Tada ,  Shuji Yonezawa ,  Chiaki Fujikoshi ,  Sae Matsumoto ,  Yuuji Kooriyama ,  Tatsuhiko Ueno

发明人： Yuusuke Tamura ,  Shinji Suzuki ,  Yukio Tada ,  Shuji Yonezawa ,  Chiaki Fujikoshi ,  Sae Matsumoto ,  Yuuji Kooriyama ,  Tatsuhiko Ueno

IPC分类号： A61K31/541 ,  C07D417/12 ,  A61P25/28

CPC分类号： C07C215/20 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/2018 ,  C07D279/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04

摘要： This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R3 a, R3 b, R3 c and R3 d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid β protein.

摘要翻译： 本发明提供式（I）的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; R1是任选取代的低级烷基，任选取代的低级烯基，任选取代的低级炔基; R2a和R2b各自独立地为氢，任选取代的低级烷基或任选取代的酰基; R3a，R3b，R3c和R3d各自独立地为氢，卤素，羟基或任选取代的低级烷基等; 其药学上可接受的盐或溶剂合物，其可用于治疗由淀粉样蛋白的生产，分泌和/或沉积诱导的疾病; 蛋白。

公开(公告)号：US20120015961A1

公开(公告)日：2012-01-19

申请号：US13260103

申请日：2010-03-29

申请人： Yuusuke Tamura ,  Shinji Suzuki ,  Sae Matsumoto ,  Akihiro Hori ,  Yuuji Kooriyama

发明人： Yuusuke Tamura ,  Shinji Suzuki ,  Sae Matsumoto ,  Akihiro Hori ,  Yuuji Kooriyama

IPC分类号： A61K31/44 ,  C07D241/24 ,  A61K31/4965 ,  C07D401/12 ,  A61K31/497 ,  C07C335/32 ,  A61K31/21 ,  C07D239/42 ,  A61K31/505 ,  A61K31/444 ,  C07D405/12 ,  A61P25/28 ,  A61P25/00 ,  A61P27/02 ,  A61P25/16 ,  C07D213/85

CPC分类号： C07D213/81 ,  C07C275/70 ,  C07C335/32 ,  C07D213/85 ,  C07D239/42 ,  C07D241/24 ,  C07D241/28 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

摘要： The present invention provides, for example, a compound of the following formula (I): wherein R1 is substituted amino and the like, R2 is halogen and the like, R3 is substituted or unsubstituted lower alkyl and the like, RA and RB are each independently hydrogen, substituted or unsubstituted lower alkyl and the like, RC and RD are each independently hydrogen, substituted or unsubstituted lower alkyl, or RC and RD together with the carbon atom to which they are attached may form a substituted or unsubstituted carbocycle, and ring A is a carbocycle or a heterocycle, its pharmaceutically acceptable salt, or a solvate thereof as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-βproteins.

摘要翻译： 本发明提供例如下式（I）的化合物：其中R1是取代氨基等，R2是卤素等，R3是取代或未取代的低级烷基等，RA和RB各自 独立地是氢，取代或未取代的低级烷基等，RC和RD各自独立地为氢，取代或未取代的低级烷基或RC和RD与它们所连接的碳原子一起形成取代或未取代的碳环，并且环 A是碳环或杂环，其药学上可接受的盐或其溶剂合物作为由淀粉样蛋白质的蛋白质的产生，分泌和/或沉积诱导的疾病的治疗剂。

公开(公告)号：US20100160290A1

公开(公告)日：2010-06-24

申请号：US12597470

申请日：2008-04-23

申请人： Naotake Kobayashi ,  Kazuo Ueda ,  Naohiro Itoh ,  Shinji Suzuki ,  Gaku Sakaguchi ,  Akira Kato ,  Akira Yukimasa ,  Akihiro Hori ,  Yuuji Kooriyama ,  Hidekazu Haraguchi ,  Ken Yasui ,  Yasuhiko Kanda

发明人： Naotake Kobayashi ,  Kazuo Ueda ,  Naohiro Itoh ,  Shinji Suzuki ,  Gaku Sakaguchi ,  Akira Kato ,  Akira Yukimasa ,  Akihiro Hori ,  Yuuji Kooriyama ,  Hidekazu Haraguchi ,  Ken Yasui ,  Yasuhiko Kanda

IPC分类号： A61K31/554 ,  C07D417/02 ,  A61K31/541 ,  C07D279/06 ,  C07D277/18 ,  A61K31/426 ,  C07D239/02 ,  A61K31/506 ,  C07D281/02 ,  A61P25/28

CPC分类号： C07D471/04 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/2018 ,  A61K31/426 ,  A61K31/506 ,  A61K31/535 ,  A61K31/54 ,  A61K31/541 ,  A61K31/554 ,  C07D239/14 ,  C07D265/08 ,  C07D277/18 ,  C07D279/06 ,  C07D281/02 ,  C07D285/36 ,  C07D295/155 ,  C07D295/192 ,  C07D405/04 ,  C07D417/04 ,  C07D417/10 ,  C07D417/12 ,  A61K2300/00

摘要： A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.

摘要翻译： 一种用于治疗含有由通式（I）表示的化合物的阿尔茨海默病的药物组合物; 其中环A是任选取代的碳环基团或任选取代的杂环基团; E为低级亚烷基等; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素，羟基等; n和m各自独立地为0〜3的整数， n + m为1〜3的整数， R5为氢原子，任意取代的低级烷基等; 其药学上可接受的盐或其溶剂合物作为活性成分。

公开(公告)号：US20120258961A1

公开(公告)日：2012-10-11

申请号：US13518285

申请日：2010-12-22

申请人： Shinji Suzuki ,  Yuuji Kooriyama

发明人： Shinji Suzuki ,  Yuuji Kooriyama

IPC分类号： A61K31/54 ,  C12N9/99 ,  A61K31/541 ,  A61P25/28 ,  A61K31/536 ,  C07D413/12 ,  A61K31/5415 ,  C07D279/06 ,  C07D417/12 ,  C07D265/20

CPC分类号： C07D265/20 ,  A61K31/536 ,  A61K31/54 ,  A61K31/541 ,  A61K31/5415 ,  C07D279/06 ,  C07D279/16 ,  C07D413/12 ,  C07D417/12

摘要： The present invention provide a medicament for treating the diseases induced by production, secretion or deposition of amyloid-β proteins, for example, a compound of the following formula (I) wherein R1, R2a, R2b, R3a, R3b, R4a, R4b, ring A, Y and the dotted line are defined in the specification, its pharmaceutically acceptable salt or a solvate thereof.

摘要翻译： 本发明提供了用于治疗由淀粉样蛋白的生产，分泌或沉积诱导的疾病的药物。 蛋白质，例如下列通式（I）的化合物，其中R1，R2a，R2b，R3a，R3b，R4a，R4b，环A，Y和虚线在本说明书中定义，其药学上可接受的盐或溶剂合物 其中。

公开(公告)号：US10421844B2

公开(公告)日：2019-09-24

申请号：US14116103

申请日：2012-05-16

申请人： Masaki Miura ,  Shinji Suzuki ,  Kinichi Morita ,  Toshikazu Kawaguchi ,  Katsuaki Shimazu

发明人： Masaki Miura ,  Shinji Suzuki ,  Kinichi Morita ,  Toshikazu Kawaguchi ,  Katsuaki Shimazu

IPC分类号： C08J7/04 ,  B32B27/16 ,  C08J7/06 ,  C08J7/12

摘要： A self-assembled monolayer is formed on the surface of a molded article without roughening the surface of the molded article to thereby perform treatment for preventing a biochemical substance from being adsorbed, for example, on a microchip substrate, and imparting functionality of immobilizing a biofunctional molecule thereto. The surface of a cyclic olefin resin molded article, for example, a microchip substrate, is irradiated with vacuum ultraviolet light having a center wavelength of 172 nm from an excimer lamp to activate a portion serving as a flow channel in the substrate. Next, the molded is immersed in a tank filled, for example, with a fluorine compound solution, and a SAM film that is a self-assembled monolayer is formed on the surface activated by ultraviolet radiation.

公开(公告)号：US09511574B2

公开(公告)日：2016-12-06

申请号：US14111548

申请日：2012-04-12

申请人： Keita Yoshihara ,  Shinji Suzuki ,  Kinichi Morita ,  Hideki Fujitsugu

发明人： Keita Yoshihara ,  Shinji Suzuki ,  Kinichi Morita ,  Hideki Fujitsugu

IPC分类号： B32B37/14 ,  B29C65/14 ,  B29C65/18 ,  B29C65/78 ,  B32B37/10 ,  B01L3/00 ,  B32B37/00 ,  B32B37/06 ,  B81C3/00 ,  B29C65/00 ,  B32B38/18 ,  B29L31/00

CPC分类号： B32B37/144 ,  B01J2219/00808 ,  B01L3/502707 ,  B01L2200/0689 ,  B01L2300/0816 ,  B29C65/1406 ,  B29C65/1432 ,  B29C65/1464 ,  B29C65/1467 ,  B29C65/18 ,  B29C65/7847 ,  B29C65/7876 ,  B29C66/0242 ,  B29C66/028 ,  B29C66/1122 ,  B29C66/45 ,  B29C66/53461 ,  B29C66/54 ,  B29C66/71 ,  B29C66/73112 ,  B29C66/73921 ,  B29C66/7465 ,  B29C66/8161 ,  B29C66/81811 ,  B29C66/8221 ,  B29C66/8242 ,  B29C66/8322 ,  B29C66/8324 ,  B29C66/91231 ,  B29C66/9141 ,  B29C66/91411 ,  B29C66/91421 ,  B29C66/91431 ,  B29C66/91445 ,  B29C66/91641 ,  B29C66/9221 ,  B29C66/9241 ,  B29C66/92445 ,  B29C66/92611 ,  B29C66/92653 ,  B29C66/92655 ,  B29C66/929 ,  B29C66/961 ,  B29L2031/756 ,  B32B37/0046 ,  B32B37/06 ,  B32B37/10 ,  B32B37/14 ,  B32B38/1858 ,  B32B2310/0831 ,  B81C3/001 ,  B81C2203/036 ,  B29K2083/00 ,  B29K2023/38 ,  B29K2033/12

摘要： Two workpieces composed of a resin workpiece and a resin workpiece, or composed of a resin workpiece and a glass substrate are bonded to each other such that troubles, such as an alignment shift and breakage etc. are not generated, while ensuring bonding uniformity. A first workpiece is placed on an inverting stage of an inverting stage unit, a second workpiece is placed on a work stage of a pressurizing stage unit, and UV light is radiated from a light irradiation unit. Then, the inverting stage is inverted 180°, the workpieces are overlapped each other on the work stage, and the workpieces are pressurized and pre-bonded to each other. Then, the workpieces in the pre-bonded state are transferred to a heating stage by a transfer means, the temperature of the workpieces is increased to a predetermined temperature by heating the workpieces, and the temperature is maintained until bonding is completed.

摘要翻译： 由树脂工件和树脂工件构成的两个由树脂工件和玻璃基板构成的工件彼此接合，从而在确保结合均匀性的同时不产生诸如取向偏移和断裂等的问题。 将第一工件放置在倒置级单元的翻转级上，将第二工件放置在加压级单元的工作台上，并从光照射单元辐射UV光。 然后，倒车台倒转180°，工件在工作台上重叠，工件相互加压并预先接合。 然后，通过转印装置将预接合状态的工件转移到加热台，通过加热工件将工件的温度升高到规定温度，并保持温度直到接合完成。

公开(公告)号：US08760678B2

公开(公告)日：2014-06-24

申请号：US13043937

申请日：2011-03-09

申请人： Kazuaki Umi ,  Tadashi Niwano ,  Shinji Suzuki

发明人： Kazuaki Umi ,  Tadashi Niwano ,  Shinji Suzuki

IPC分类号： G06K15/00

CPC分类号： H04N1/0044 ,  H04N1/00453 ,  H04N1/00461 ,  H04N1/00474 ,  H04N1/00588 ,  H04N1/00602 ,  H04N1/00615 ,  H04N1/3263 ,  H04N1/32657

摘要： An image displaying apparatus includes a control unit and a display unit. The image displaying apparatus is connected to an image reading apparatus that includes a multifeed detecting mechanism. The control unit includes a display control unit that displays (i) an image of a medium which is read by the image reading apparatus and in which multifeed is detected by the multifeed detecting mechanism and (ii) a multifeed detected portion detected by the multifeed detecting mechanism on the display unit.

摘要翻译： 图像显示装置包括控制单元和显示单元。 图像显示装置连接到包括多页进纸检测机构的图像读取装置。 控制单元包括显示控制单元，其显示（i）由图像读取装置读取的介质的图像，并且由多页进纸检测机构检测到多页进纸;以及（ii）由多页进纸检测检测到的多页进纸检测部分 机构在显示单元上。