公开(公告)号：US20140275274A1

公开(公告)日：2014-09-18

申请号：US13826257

申请日：2013-03-14

Applicant: ABBOTT MEDICAL OPTICS INC.

Inventor： Stanley W. Huth ,  Denise Tran

IPC: A61K31/155 ,  A01N37/52

CPC classification number: A61K31/155 ,  A01N37/52 ,  A61L12/14 ,  A61L12/141 ,  A61L12/145

Abstract: Compositions and methods for disinfecting contact lenses using the compositions are disclosed. The compositions include a combination of alexidine and chlorhexidine, which surprisingly causes the composition to exhibit synergistic antimicrobial activity against Candida albicans by reducing a concentration of Candida albicans by at least 1.2 log.

Abstract translation: 公开了使用该组合物消毒隐形眼镜的组合物和方法。 组合物包括阿维膦酸和氯己定的组合，令人惊奇的是通过将白色念珠菌的浓度降低至少1.2log，使组合物对白色念珠菌显示出协同的抗微生物活性。

公开(公告)号：US20130208246A1

公开(公告)日：2013-08-15

申请号：US13755295

申请日：2013-01-31

Applicant: Abbott Medical Optics Inc.

Inventor： Stanley W. Huth ,  Denise Tran

IPC: A61B3/10

CPC classification number: A61B3/101

Abstract: Methods and devices measure eye blinks and tear film lipid and aqueous layer thickness before and following ophthalmic formula application onto the ocular surface, especially wherein the ophthalmic formula is an artificial tear. The methods and devices are suitable for dry eye diagnosis. The methods and devices are suitable for use to evaluate ophthalmic formula effects on the tear film and to use such information to diagnose ophthalmic formula treatment of ocular disease conditions such as dry eye in the absence of contact lens wear or post-surgical eye drop treatment and diagnosis. The methods and devices are also suitable for use in the optimization of ophthalmic drug dosage forms and sustained drug release.

公开(公告)号：US20150351627A1

公开(公告)日：2015-12-10

申请号：US14298176

申请日：2014-06-06

Applicant: Abbott Medical Optics Inc.

Inventor： Stan Huth ,  Denise Tran

IPC: A61B3/10

CPC classification number: A61B3/101

Abstract: A method of determining tear film lipid layer thickness. The method includes the steps of measuring a tear film aqueous plus lipid layer relative reflectance spectrum using a wavelength-dependent optical interferometer; converting the measured tear film aqueous plus lipid layer relative reflectance spectrum to a calculated absolute reflectance spectrum; and comparing the calculated absolute reflectance spectrum to a theoretical absolute lipid reflectance spectrum to determine a tear film lipid layer thickness.

Abstract translation: 确定泪膜脂质层厚度的方法。 该方法包括以下步骤：使用波长相关的光学干涉仪测量泪膜水相加脂质层相对反射光谱; 将测量的泪膜水相加脂质层相对反射光谱转换为计算的绝对反射光谱; 并将计算的绝对反射光谱与理论绝对脂质反射光谱进行比较，以确定泪膜脂质层厚度。

公开(公告)号：US09173558B2

公开(公告)日：2015-11-03

申请号：US14058564

申请日：2013-10-21

Applicant: Abbott Medical Optics Inc.

Inventor： Stanley Huth ,  Denise Tran ,  Huawei Zhao ,  Alkan Gulses

IPC: A61B3/10 ,  A61B3/103 ,  A61B3/15 ,  A61F9/008

CPC classification number: A61B3/1015 ,  A61B3/101 ,  A61B3/103 ,  A61B3/152 ,  A61F2009/00872

Abstract: Disclosed herein is a method of calculating tear film lipid and aqueous layer thicknesses and/or corneal surface refractive index from interferometry data obtained from simultaneous measurements of the aqueous and lipid layers of the tear film along with a measurement of the corneal surface reflectance.

Abstract translation: 本文公开了一种从同时测量泪膜的水性和脂质层以及角膜表面反射率的测量获得的干涉测量数据计算泪膜脂质和水层厚度和/或角膜表面折射率的方法。

公开(公告)号：US08657447B2

公开(公告)日：2014-02-25

申请号：US13755295

申请日：2013-01-31

Applicant: Abbott Medical Optics Inc.

Inventor： Stanley W Huth ,  Denise Tran

IPC: A61B3/00

CPC classification number: A61B3/101

Abstract: Methods and devices measure eye blinks and tear film lipid and aqueous layer thickness before and following ophthalmic formula application onto the ocular surface, especially wherein the ophthalmic formula is an artificial tear. The methods and devices are suitable for dry eye diagnosis. The methods and devices are suitable for use to evaluate ophthalmic formula effects on the tear film and to use such information to diagnose ophthalmic formula treatment of ocular disease conditions such as dry eye in the absence of contact lens wear or post-surgical eye drop treatment and diagnosis. The methods and devices are also suitable for use in the optimization of ophthalmic drug dosage forms and sustained drug release.

Abstract translation: 方法和装置测量眼用配方之前和之后的眼睛眨眼和撕裂膜脂质和水层厚度，特别是其中眼用配方是人造眼泪。 该方法和装置适用于干眼诊断。 所述方法和装置适合用于评估眼用配方对泪液膜的影响，并使用此类信息来诊断在没有接触镜磨损或手术后滴眼治疗的情况下眼部疾病状况如眼睛眼病的眼科配方治疗，以及 诊断。 所述方法和装置也适用于优化眼药物剂型和持续的药物释放。