公开(公告)号：US20170334912A1

公开(公告)日：2017-11-23

申请号：US15668260

申请日：2017-08-03

Applicant: Agency for Science, Technology and Research

Inventor： Soo Yei Ho ,  Stephanie Eliane Blanchard ,  Athisayamani Jeyaraj Duraiswamy ,  Jenefer Alam ,  Vikrant Arun Adsool

IPC: C07D473/06 ,  A61K31/522 ,  A61K31/5377 ,  C07D473/08

CPC classification number: C07D473/06 ,  A61K31/522 ,  A61K31/5377 ,  C07D473/08

Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

公开(公告)号：US20160090386A1

公开(公告)日：2016-03-31

申请号：US14893172

申请日：2014-05-19

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Soo Yei Ho ,  Stephanie Eliane Blanchard ,  Athisayamani Jeyaraj Duraiswamy ,  Jenefer Alam ,  Vikrant Arun Adsool

IPC: C07D473/06 ,  C07D473/08

CPC classification number: C07D473/06 ,  A61K31/522 ,  A61K31/5377 ,  C07D473/08

Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

Abstract translation: 本发明涉及通用结构（I）化合物在Wnt途径调节中的应用[本文中应该插入其中R 1，R 2，R 3，R 4和R 5各自独立地为H或烷基; D选自H，卤素，烷基，环烷基，芳基和二烷基氨基，每个（H和卤素除外）任选被取代; Ar是任选取代的芳基或杂芳基; Cy是芳基，杂芳基或含有至少一个杂原子的饱和环，各自任选被取代; n为1〜3的整数。