公开(公告)号：US11555037B2

公开(公告)日：2023-01-17

申请号：US17100474

申请日：2020-11-20

Applicant: Agency for Science, Technology and Research

Inventor： Soo Yei Ho ,  Stephanie Eliane Blanchard ,  Athisayamani Jeyaraj Duraiswamy ,  Jenefer Alam ,  Vikrant Arun Adsool

IPC: C07D473/06 ,  A61K31/522 ,  A61K31/5377 ,  C07D473/08

Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

公开(公告)号：US12227511B2

公开(公告)日：2025-02-18

申请号：US18144641

申请日：2023-05-08

Applicant: Agency for Science, Technology and Research

Inventor： Vikrant Arun Adsool

IPC: C07D491/08 ,  C07D215/233 ,  C07D401/12 ,  C07D451/06 ,  C07D451/14

Abstract: The present disclosure relates to derivatives of bicyclic compounds and their uses in therapy. In particular, the present disclosure relates to derivatives of bicyclic compounds for use in modulating kinase enzymatic activity and accordingly modulating kinase-dependent diseases and conditions such as cancer and in specific embodiments, hepatocellular carcinoma (HCC). The present disclosure also relates to methods of synthesizing these compounds.

公开(公告)号：US11702425B2

公开(公告)日：2023-07-18

申请号：US17265175

申请日：2019-07-23

Applicant: Agency for Science, Technology and Research

Inventor： Vikrant Arun Adsool

IPC: C07D491/08 ,  C07D215/233 ,  C07D401/12 ,  C07D451/06 ,  C07D451/14

CPC classification number: C07D491/08 ,  C07D215/233 ,  C07D401/12 ,  C07D451/06 ,  C07D451/14

Abstract: The present disclosure relates to derivatives of bicyclic compounds and their uses in therapy. In particular, the present disclosure relates to derivatives of bicyclic compounds for use in modulating kinase enzymatic activity and accordingly modulating kinase-dependent diseases and conditions such as cancer and in specific embodiments, hepatocellular carcinoma (HCC). The present disclosure also relates to methods of synthesizing these compounds.

公开(公告)号：US09926320B2

公开(公告)日：2018-03-27

申请号：US14893172

申请日：2014-05-19

Applicant: Agency for Science, Technology and Research

Inventor： Soo Yei Ho ,  Stephanie Eliane Blanchard ,  Athisayamani Jeyaraj Duraiswamy ,  Jenefer Alam ,  Vikrant Arun Adsool

IPC: A61K31/522 ,  C07D473/06 ,  A61K31/5377 ,  C07D473/08

CPC classification number: C07D473/06 ,  A61K31/522 ,  A61K31/5377 ,  C07D473/08

Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

公开(公告)号：US10526335B2

公开(公告)日：2020-01-07

申请号：US15899675

申请日：2018-02-20

Applicant: Agency for Science, Technology and Research

Inventor： Soo Yei Ho ,  Stephanie Eliane Blanchard ,  Athisayamani Jeyaraj Duraiswamy ,  Jenefer Alam ,  Vikrant Arun Adsool

IPC: C07D473/06 ,  A61K31/522 ,  A61K31/5377 ,  C07D473/08

Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

公开(公告)号：US10472360B2

公开(公告)日：2019-11-12

申请号：US15668260

申请日：2017-08-03

Applicant: Agency for Science, Technology and Research

Inventor： Soo Yei Ho ,  Stephanie Eliane Blanchard ,  Athisayamani Jeyaraj Duraiswamy ,  Jenefer Alam ,  Vikrant Arun Adsool

IPC: A61K31/522 ,  C07D473/06 ,  A61K31/5377 ,  C07D473/08

Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

公开(公告)号：US20170334912A1

公开(公告)日：2017-11-23

申请号：US15668260

申请日：2017-08-03

Applicant: Agency for Science, Technology and Research

Inventor： Soo Yei Ho ,  Stephanie Eliane Blanchard ,  Athisayamani Jeyaraj Duraiswamy ,  Jenefer Alam ,  Vikrant Arun Adsool

IPC: C07D473/06 ,  A61K31/522 ,  A61K31/5377 ,  C07D473/08

CPC classification number: C07D473/06 ,  A61K31/522 ,  A61K31/5377 ,  C07D473/08

Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

公开(公告)号：US20160090386A1

公开(公告)日：2016-03-31

申请号：US14893172

申请日：2014-05-19

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Soo Yei Ho ,  Stephanie Eliane Blanchard ,  Athisayamani Jeyaraj Duraiswamy ,  Jenefer Alam ,  Vikrant Arun Adsool

IPC: C07D473/06 ,  C07D473/08

CPC classification number: C07D473/06 ,  A61K31/522 ,  A61K31/5377 ,  C07D473/08

Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.

Abstract translation: 本发明涉及通用结构（I）化合物在Wnt途径调节中的应用[本文中应该插入其中R 1，R 2，R 3，R 4和R 5各自独立地为H或烷基; D选自H，卤素，烷基，环烷基，芳基和二烷基氨基，每个（H和卤素除外）任选被取代; Ar是任选取代的芳基或杂芳基; Cy是芳基，杂芳基或含有至少一个杂原子的饱和环，各自任选被取代; n为1〜3的整数。