公开(公告)号：US11339223B2

公开(公告)日：2022-05-24

申请号：US16058817

申请日：2018-08-08

Applicant: ALECTOR LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas ,  Robert Pejchal ,  Anthony B. Cooper

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11208488B2

公开(公告)日：2021-12-28

申请号：US16134830

申请日：2018-09-18

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas ,  Robert Pejchal ,  Anthony B. Cooper

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11186645B2

公开(公告)日：2021-11-30

申请号：US16741658

申请日：2020-01-13

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas ,  Robert Pejchal ,  Anthony B. Cooper

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11084875B2

公开(公告)日：2021-08-10

申请号：US16382117

申请日：2019-04-11

Applicant: ALECTOR LLC

Inventor： Kate Monroe ,  Tina Schwabe ,  Francesca Avogadri-Connors ,  Ilaria Tassi ,  Helen Lam ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61K39/00

Abstract: The invention is generally directed to methods and compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 and/or human TREM2. The methods provided herein find use in preventing, reducing risk, or treating an individual having dementia, frontotemporal dementia, Alzheimer's disease, Nasu-Hakola disease, or multiple sclerosis.

公开(公告)号：US20190174730A1

公开(公告)日：2019-06-13

申请号：US16218299

申请日：2018-12-12

Applicant: Alector LLC

Inventor： Ilaria Tassi ,  Asa Abeliovich ,  Seung-Joo Lee ,  Arnon Rosenthal ,  Tina Schwabe

IPC: A01K67/027 ,  C07K14/705 ,  A61K49/00

Abstract: Provided herein are transgenic non-human animals whose genomes comprise two or more human genes selected from TREM1, TREML1, TREM2, TREML2, and TREML4, to methods of screening candidate agents that bind to and/or modulate the function and/or activity of at least one of the human genes in the transgenic non-human animals, and to methods of screening candidate agents to determine their effect on one or more activities and/or functions associated with expression of at least one of the human genes in the transgenic non-human animals. Further provided herein are methods of recapitulating a human TREM immune system in a non-human animal, and methods of generating a non-human animal disease model comprising a human TREM repertoire.

公开(公告)号：US12297277B2

公开(公告)日：2025-05-13

申请号：US17836707

申请日：2022-06-09

Applicant: Alector LLC

Inventor： Tina Schwabe ,  Michael Kurnellas ,  Arnon Rosenthal ,  Robert Pejchal ,  Anthony B. Cooper

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11667699B2

公开(公告)日：2023-06-06

申请号：US16943123

申请日：2020-07-30

Applicant: Alector LLC

Inventor： Jeonghoon Sun ,  Wei-Hsien Ho ,  Muhammad A. Alhawagri ,  Philip Ling Kong ,  Herve Rhinn ,  Hua Long ,  Karpagam Srinivasan ,  Ananya Mitra ,  Daniel P. Bermingham ,  Klaus-Dieter Heger ,  Santiago Viveros Salazar ,  Francesca Cignarella ,  Ilaria Tassi ,  Tina Schwabe ,  Angie Grace Yee ,  Arnon Rosenthal

IPC: C07K16/18 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, humanized antibodies and antibody fragments, that specifically bind a MS4A4A polypeptide, e.g., a mammalian MS4A4A or human MS4A4A, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US10428150B2

公开(公告)日：2019-10-01

申请号：US15999627

申请日：2018-08-20

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190085084A1

公开(公告)日：2019-03-21

申请号：US16134830

申请日：2018-09-18

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190062433A1

公开(公告)日：2019-02-28

申请号：US16058817

申请日：2018-08-08

Applicant: ALECTOR LLC

Inventor： Arnon Rosenthal ,  Tina Schwabe ,  Michael Kurnellas

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.