公开(公告)号：US11634489B2

公开(公告)日：2023-04-25

申请号：US16835140

申请日：2020-03-30

Applicant: Alector LLC

Inventor： Tina Schwabe ,  Eric Brown ,  Philip Kong ,  Ilaria Tassi ,  Seung-Joo Lee ,  Arnon Rosenthal ,  Robert Pejchal ,  Nels P. Nielson

IPC: A61P25/28 ,  A61K39/00 ,  C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11667699B2

公开(公告)日：2023-06-06

申请号：US16943123

申请日：2020-07-30

Applicant: Alector LLC

Inventor： Jeonghoon Sun ,  Wei-Hsien Ho ,  Muhammad A. Alhawagri ,  Philip Ling Kong ,  Herve Rhinn ,  Hua Long ,  Karpagam Srinivasan ,  Ananya Mitra ,  Daniel P. Bermingham ,  Klaus-Dieter Heger ,  Santiago Viveros Salazar ,  Francesca Cignarella ,  Ilaria Tassi ,  Tina Schwabe ,  Angie Grace Yee ,  Arnon Rosenthal

IPC: C07K16/18 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, humanized antibodies and antibody fragments, that specifically bind a MS4A4A polypeptide, e.g., a mammalian MS4A4A or human MS4A4A, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US10676525B2

公开(公告)日：2020-06-09

申请号：US16054680

申请日：2018-08-03

Applicant: ALECTOR LLC

Inventor： Tina Schwabe ,  Eric Brown ,  Philip Kong ,  Ilaria Tassi ,  Seung-Joo Lee ,  Arnon Rosenthal ,  Robert Pejchal ,  Nels P. Nielson

IPC: C07K16/28 ,  A61P25/28 ,  A61K39/00

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190315858A1

公开(公告)日：2019-10-17

申请号：US16382117

申请日：2019-04-11

Applicant: ALECTOR LLC

Inventor： Kate Monroe ,  Tina Schwabe ,  Francesca Avogadri-Connors ,  Ilaria Tassi ,  Helen Lam ,  Arnon Rosenthal

IPC: C07K16/28

Abstract: The invention is generally directed to methods and compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 and/or human TREM2. The methods provided herein find use in preventing, reducing risk, or treating an individual having dementia, frontotemporal dementia, Alzheimer's disease, Nasu-Hakola disease, or multiple sclerosis.

公开(公告)号：US11084875B2

公开(公告)日：2021-08-10

申请号：US16382117

申请日：2019-04-11

Applicant: ALECTOR LLC

Inventor： Kate Monroe ,  Tina Schwabe ,  Francesca Avogadri-Connors ,  Ilaria Tassi ,  Helen Lam ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61K39/00

Abstract: The invention is generally directed to methods and compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 and/or human TREM2. The methods provided herein find use in preventing, reducing risk, or treating an individual having dementia, frontotemporal dementia, Alzheimer's disease, Nasu-Hakola disease, or multiple sclerosis.

公开(公告)号：US20190174730A1

公开(公告)日：2019-06-13

申请号：US16218299

申请日：2018-12-12

Applicant: Alector LLC

Inventor： Ilaria Tassi ,  Asa Abeliovich ,  Seung-Joo Lee ,  Arnon Rosenthal ,  Tina Schwabe

IPC: A01K67/027 ,  C07K14/705 ,  A61K49/00

Abstract: Provided herein are transgenic non-human animals whose genomes comprise two or more human genes selected from TREM1, TREML1, TREM2, TREML2, and TREML4, to methods of screening candidate agents that bind to and/or modulate the function and/or activity of at least one of the human genes in the transgenic non-human animals, and to methods of screening candidate agents to determine their effect on one or more activities and/or functions associated with expression of at least one of the human genes in the transgenic non-human animals. Further provided herein are methods of recapitulating a human TREM immune system in a non-human animal, and methods of generating a non-human animal disease model comprising a human TREM repertoire.

公开(公告)号：US20240254227A1

公开(公告)日：2024-08-01

申请号：US18637960

申请日：2024-04-17

Applicant: Alector LLC

Inventor： Sarah Emily Headland ,  Ilaria Tassi ,  Chenyu A. Lee ,  Earl Kim ,  Adiljan Ibrahim ,  Marina Roell ,  Angie Grace Yee

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/92

Abstract: The present disclosure is generally directed to antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a CD300LB polypeptide, e.g., a mammalian CD300LB or human CD300LB, and use of such compositions in preventing, reducing risk, or treating a disease or disorder an individual in need thereof.

公开(公告)号：US11472874B2

公开(公告)日：2022-10-18

申请号：US16965676

申请日：2019-01-31

Applicant: Alector LLC

Inventor： Philip Kong ,  Herve Rhinn ,  Tina Schwabe ,  Angie Yee ,  Ilaria Tassi ,  Muhammad Abbas Alhawagri ,  Arnon Rosenthal

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a MS4A4A polypeptide, e.g., a mammalian MS4A4A or human MS4A4A, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11470827B2

公开(公告)日：2022-10-18

申请号：US16218299

申请日：2018-12-12

Applicant: Alector LLC

Inventor： Ilaria Tassi ,  Asa Abeliovich ,  Seung-Joo Lee ,  Arnon Rosenthal ,  Tina Schwabe

IPC: A01K67/027 ,  C07H21/04 ,  C07K14/705 ,  A61K49/00

Abstract: Provided herein are transgenic non-human animals whose genomes comprise two or more human genes selected from TREM1, TREML1, TREM2, TREML2, and TREML4, to methods of screening candidate agents that bind to and/or modulate the function and/or activity of at least one of the human genes in the transgenic non-human animals, and to methods of screening candidate agents to determine their effect on one or more activities and/or functions associated with expression of at least one of the human genes in the transgenic non-human animals. Further provided herein are methods of recapitulating a human TREM immune system in a non-human animal, and methods of generating a non-human animal disease model comprising a human TREM repertoire.