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公开(公告)号：US20190233528A1
公开(公告)日：2019-08-01
申请号：US16264371
申请日：2019-01-31
Applicant: Pfizer Inc.
Inventor： Surabhi Srivatsa Srinivasan , Niranjana Aditi Nagarajan , Siler Panowski , Yoon Park , Tao Sai , Barbra Johnson SASU , Thomas John Van Blarcom , Mathilde Brunnhilde Dusseaux , Roman Ariel Galetto
IPC: C07K16/28 , C07K14/725 , A61K39/00 , A61P35/02 , A61P35/04
CPC classification number: C07K16/2875 , A61K39/001129 , A61K39/001138 , A61K2039/5156 , A61P35/02 , A61P35/04 , C07K14/7051 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/02 , C07K2319/03 , C07K2319/33
Abstract: The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic methods for use of these CARs and engineered immune cells comprising these CARs for the treatment of a condition associated with malignant cells expressing CD70 (e.g., cancer).
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公开(公告)号：US11155630B2
公开(公告)日：2021-10-26
申请号：US17129833
申请日：2020-12-21
Applicant: PFIZER INC.
Inventor： Tracy Chia-Chien Kuo , Javier Fernando Chaparro Riggers , Wei Chen , Amy Shaw-Ru Chen , Edward Derrick Pascua , Thomas John Van Blarcom , Leila Marie Boustany , Weihsien Ho , Yik Andy Yeung , Pavel Strop , Arvind Rajpal
IPC: C07K16/28 , C07K16/30 , A61K39/395 , A61K31/454 , A61K31/704 , A61K31/69 , A61K47/68 , A61K39/00
Abstract: The present invention relates to bispecific antibodies that specific bind to BCMA (B-Cell Maturation Antigen) and CD3 (Cluster of Differentiation 3). Method of making the bispecific antibodies and method of using the bispecific antibodies for the treatment of multiple myeloma are also provided.
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公开(公告)号：US10040860B2
公开(公告)日：2018-08-07
申请号：US15878344
申请日：2018-01-23
Applicant: PFIZER INC.
Inventor： Tracy Chia-Chien Kuo , Javier Fernando Chaparro Riggers , Wei Chen , Amy Shaw-Ru Chen , Edward Derrick Pascua , Thomas John Van Blarcom , Leila Marie Boustany , Weihsien Ho , Yik Andy Yeung , Pavel Strop , Arvind Rajpal
IPC: C07K16/00 , C07K16/28 , A61K39/395 , A61K31/454 , A61K47/68 , A61K31/69 , A61K31/704 , A61K39/00
CPC classification number: C07K16/2878 , A61K31/454 , A61K31/69 , A61K31/704 , A61K39/3955 , A61K39/39558 , A61K47/6801 , A61K47/6849 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , A61K2300/00
Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.
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公开(公告)号：US11702474B2
公开(公告)日：2023-07-18
申请号：US17120935
申请日：2020-12-14
Applicant: Pfizer Inc.
Inventor： Javier Fernando Chaparro Riggers , Shih-Hsun Chen , Sheng Ding , Pawel Kamil Dominik , Shahram Salek-Ardakani , Jessica Lynn Stanfield , Thomas John Van Blarcom
CPC classification number: C07K16/2827 , A61P35/00 , C07K16/2803 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Antibodies that specifically bind to CD47 and antibodies that specifically bind to PD-L1 are provided, as well as CD47/PD-L1 bispecific antibodies. Also provided are uses of these antibodies, and related compositions and methods.
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公开(公告)号：US20230002498A1
公开(公告)日：2023-01-05
申请号：US17830324
申请日：2022-06-01
Applicant: Pfizer Inc.
Inventor： Siler Panowski , Tao Sai , Barbra Johnson Sasu , Surabhi Srivatsa Srinivasan , Thomas John Van Blarcom
Abstract: The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of CD70-mediated pathologies, including cancer.
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Patent Agency Ranking
公开(公告)号：US20250145725A1
公开(公告)日：2025-05-08
申请号：US18919327
申请日：2024-10-17
Applicant: Pfizer Inc.
Inventor： Surabhi Srivatsa Srinivasan , Niranjana Aditi Nagarajan , Siler Panowski , Yoon Park , Tao Sai , Barbra Johnson Sasu , Thomas John Van Blarcom , Mathilde Brunnhilde Dusseaux , Roman Galetto
IPC: C07K16/28 , A61K39/00 , A61K40/11 , A61K40/31 , A61K40/42 , A61P35/02 , A61P35/04 , C07K14/725 , C12N5/0783
Abstract: The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic methods for use of these CARs and engineered immune cells comprising these CARs for the treatment of a condition associated with malignant cells expressing CD70 (e.g., cancer).
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公开(公告)号：US20190233529A1
公开(公告)日：2019-08-01
申请号：US16264485
申请日：2019-01-31
Applicant: Pfizer Inc.
Inventor： Siler Panowski , Tao Sai , Barbra Johnson Sasu , Surabhi Srivatsa Srinivasan , Thomas John Van Blarcom
CPC classification number: C07K16/2875 , A61K2039/505 , A61P35/00 , C07K16/2809 , C07K2317/31 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of CD70-mediated pathologies, including cancer.
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公开(公告)号：US10294304B2
公开(公告)日：2019-05-21
申请号：US15085317
申请日：2016-03-30
Applicant: PFIZER INC.
Inventor： Tracy Chia-Chien Kuo , Bijan Andre Boldajipour , Javier Fernando Chaparro Riggers , Philippe Duchateau , Roman Galetto , Alexandre Juillerat , Thomas Charles Pertel , Arvind Rajpal , Barbra Johnson Sasu , Cesar Adolfo Sommer , Julien Valton , Thomas John Van Blarcom
IPC: C07K16/28 , A61K39/395 , C12N15/63 , C07K14/725 , C07K14/705 , A61K39/00 , A61K31/7076 , A61K35/17 , A61K38/00
Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).
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公开(公告)号：US09969809B2
公开(公告)日：2018-05-15
申请号：US15085644
申请日：2016-03-30
Applicant: PFIZER INC.
Inventor： Tracy Chia-Chien Kuo , Javier Fernando Chaparro Riggers , Wei Chen , Amy Shaw-Ru Chen , Edward Derrick Pascua , Thomas John Van Blarcom , Leila Marie Boustany , Weihsien Ho , Yik Andy Yeung , Pavel Strop , Arvind Rajpal
IPC: C07K16/00 , C07K16/28 , A61K39/395 , A61K31/454 , A61K31/704 , A61K47/48 , A61K31/69 , A61K39/00
CPC classification number: C07K16/2878 , A61K31/454 , A61K31/69 , A61K31/704 , A61K39/3955 , A61K39/39558 , A61K47/6801 , A61K47/6849 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , A61K2300/00
Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.
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公开(公告)号：US11987634B2
公开(公告)日：2024-05-21
申请号：US17830324
申请日：2022-06-01
Applicant: Pfizer Inc.
Inventor： Siler Panowski , Tao Sai , Barbra Johnson Sasu , Surabhi Srivatsa Srinivasan , Thomas John Van Blarcom
CPC classification number: C07K16/2875 , A61P35/00 , C07K16/2809 , A61K2039/505 , C07K2317/31 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of CD70-mediated pathologies, including cancer.
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