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11.发明公开公开(公告)号：US20240218386A1
公开(公告)日：2024-07-04
申请号：US17781797
申请日：2020-12-02
Applicant: ALTRIA CLIENT SERVICES LLC
Inventor： Chengalrayan KUDITHIPUDI , Chengalrayan KUDITHIPUDI , Yanxin SHEN , Dongmei XU
CPC classification number: C12N15/8243 , A24B13/00 , A24B15/00
Abstract: The present disclosure provides composition and methods for manipulating alkaloid or nicotine levels in tobacco plants. Also provided are the identification and genetic engineering of target genes (e.g., arginine decarboxylase (ADC), aspartate oxidase (AO), or ornithine decarboxylase (ODC)) for producing tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.
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公开(公告)号：US20220243215A1
公开(公告)日：2022-08-04
申请号：US17591033
申请日：2022-02-02
Inventor： Chengalrayan KUDITHIPUDI , Yanxin SHEN , Dongmei XU , Michael Paul TIMKO , Roel RABARA
IPC: C12N15/82 , C07K14/415 , C12P5/00
Abstract: Composition and methods for the modification of the secondary metabolic functions of glandular trichomes in plants, such as tobacco or Cannabis, that control the formation of terpenes that impart specific flavor and aroma characteristics to the plant leaves are provided. Enhanced terpene production and composition are achieved through targeted modification in the biochemical synthesis pathways for menthol and cis-abienol. This application provides novel nucleotide sequences encoding the enzymology for production of these terpenes in tobacco and Cannabis application to their use plants.
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13.发明申请公开(公告)号：US20200377904A1
公开(公告)日：2020-12-03
申请号：US16886118
申请日：2020-05-28
Applicant: ALTRIA CLIENT SERVICES LLC
IPC: C12N15/82
Abstract: The present disclosure provides methods and compositions for controlling sucker growth in tobacco by altering the expression of different target genes.
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14.发明申请公开(公告)号：US20200029522A1
公开(公告)日：2020-01-30
申请号：US16523326
申请日：2019-07-26
Applicant: ALTRIA CLIENT SERVICES LLC
Inventor： Chengalrayan KUDITHIPUDI , Dong QI , Yanxin SHEN , Ujwala WAREK , James A. STRICKLAND , Dongmei XU
IPC: A01H5/12 , A01H6/82 , C12Q1/6827
Abstract: The present disclosure provides compositions and methods related to tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.
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公开(公告)号：US20240368614A1
公开(公告)日：2024-11-07
申请号：US18651995
申请日：2024-05-01
Applicant: Altria Client Services LLC
Inventor： Chengalrayan KUDITHIPUDI , Dongmei XU , James STRICKLAND , Yanxin SHEN
Abstract: The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), increase phenylalanine, or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.
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Patent Agency Ranking
16.发明公开公开(公告)号：US20230399651A1
公开(公告)日：2023-12-14
申请号：US17767692
申请日：2020-10-09
Applicant: Altria Client Services LLC
Inventor： Dong QI , Chengalrayan KUDITHIPUDI , Yanxin SHEN
CPC classification number: C12N15/8243 , A24B15/12 , A24B13/00
Abstract: The present disclosure provides compositions and methods related to tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.
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17.发明公开公开(公告)号：US20230145103A1
公开(公告)日：2023-05-11
申请号：US17893246
申请日：2022-08-23
Applicant: ALTRIA CLIENT SERVICES LLC
IPC: C12N15/82
CPC classification number: C12N15/8262
Abstract: The present disclosure provides methods and compositions for controlling sucker growth in tobacco by altering the expression of different target genes.
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18.发明申请公开(公告)号：US20230035750A1
公开(公告)日：2023-02-02
申请号：US17406829
申请日：2021-08-19
Applicant: ALTRIA CLIENT SERVICES LLC
Inventor： Dongmei XU , Jesse FREDERICK , Chengalrayan KUDITHIPUDI , Yanxin SHEN , James STRICKLAND , Jaemo YANG
IPC: C12N15/82
Abstract: The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.
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公开(公告)号：US20220380788A1
公开(公告)日：2022-12-01
申请号：US17835433
申请日：2022-06-08
Applicant: ALTRIA CLIENT SERVICES LLC
Inventor： Chengalrayan KUDITHIPUDI , Dong QI , Yanxin SHEN , Ujwala WAREK , James A. STRICKLAND , Dongmei XU
IPC: C12N15/82 , A01H6/82 , A01H5/12 , C12Q1/6827
Abstract: The present disclosure provides compositions and methods related to tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.
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20.发明申请公开(公告)号：US20200318129A1
公开(公告)日：2020-10-08
申请号：US16908891
申请日：2020-06-23
Applicant: Altria Client Services LLC
Inventor： Dongmei XU , Chengalrayan KUDITHIPUDI , Yanxin SHEN , Jaemo YANG , Jesse FREDERICK , James STRICKLAND
IPC: C12N15/82 , C07K14/415 , A24B13/00 , A24B15/10
Abstract: The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.
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