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公开(公告)号：US11059908B2
公开(公告)日：2021-07-13
申请号：US16338292
申请日：2017-09-28
Applicant: AMGEN INC.
Inventor： Joon Hoi Huh , Riki Stevenson , Pavel Bondarenko , Andrew Nichols , Da Ren , Neeraj Jagdish Agrawal
Abstract: The present invention concerns a method for preparing antigen binding proteins with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.
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公开(公告)号：US10851144B2
公开(公告)日：2020-12-01
申请号：US15565376
申请日：2016-05-04
Applicant: AMGEN INC.
Inventor： Eric Alan Butz , Christy Ann Thomson , Marc Alain Gavin , Ian Nevin Foltz , Dong Xia , Dina N. Alcorn , Ai Ching Lim , Randal Robert Ketchum , Kathy Manchulenko , Laura Sekirov , Kelly Ann Berry , Cyr Clovis Chua De Imus , Neeraj Jagdish Agrawal , Gunasekaran Kannan , Li Li
Abstract: Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and complexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when expressed in mammalian cells. Also provided herein are methods of making and using the compositions of the present invention.
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Patent Agency Ranking
公开(公告)号：US20250154281A1
公开(公告)日：2025-05-15
申请号：US19026217
申请日：2025-01-16
Applicant: AMGEN INC. , XENCOR, INC.
Inventor： Olivier Nolan-Stevaux , Cong Li , Christopher M. Murawsky , Benjamin M. Alba , Neeraj Jagdish Agrawal , Kevin Campbell Graham , Jennitte LeAnn Stevens , Gregory Moore
Abstract: The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.
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公开(公告)号：US20240301087A1
公开(公告)日：2024-09-12
申请号：US18602865
申请日：2024-03-12
Applicant: AMGEN INC. , XENCOR, INC.
Inventor： Olivier Nolan-Stevaux , Cong Li , Christopher M. Murawsky , Benjamin M. Alba , Neeraj Jagdish Agrawal , Kevin Campbell Graham , Jennitte LeAnn Stevens , Gregory Moore
CPC classification number: C07K16/3069 , A61P35/00 , C07K16/2809 , C07K16/2818 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/622 , C07K2317/73 , C07K2317/92
Abstract: The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.
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公开(公告)号：US20230159656A1
公开(公告)日：2023-05-25
申请号：US18054426
申请日：2022-11-10
Applicant: Amgen Inc.
Inventor： Olivier Nolan-Stevaux , Cong Li , Christopher M. Murawsky , Benjamin M. Alba , Neeraj Jagdish Agrawal , Kevin Graham , Jennitte LeAnn Stevens
CPC classification number: C07K16/3069 , A61P35/00 , C07K16/2809 , C07K16/2818 , A61K2039/505
Abstract: The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.
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公开(公告)号：US11530274B2
公开(公告)日：2022-12-20
申请号：US16634571
申请日：2019-07-02
Applicant: AMGEN INC. , XENCOR, INC.
Inventor： Olivier Nolan-Stevaux , Cong Li , Christopher M. Murawsky , Benjamin M. Alba , Neeraj Jagdish Agrawal , Kevin Graham , Jennitte LeAnn Stevens , Gregory Moore
Abstract: The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.
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公开(公告)号：US20210179731A1
公开(公告)日：2021-06-17
申请号：US16634571
申请日：2019-07-02
Applicant: AMGEN INC. , XENCOR, INC.
Inventor： Olivier Nolan-Stevaux , Cong Li , Christopher M. Murawsky , Benjamin M. Alba , Neeraj Jagdish Agrawal , Kevin Graham , Jennitte LeAnn Stevens , Gregory Moore
Abstract: The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.
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